<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14120

Description Cyclin dependent kinase 8
SequenceMAPVMMDYEFKIKTQNERSKVEDLFDYEGCKVGRGTYGHVYKARRKDGSDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKANKKSVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQEKDWEDIRKMPEHATLVKDFKRSNYQNCSLSKYMDRHKIKPDSKAFSLLQRLLLMDPNRRITSEQAMQDPYFSEDPLPTQDVFAGCPIPYPKREFLTDDDQEDKSDSKARQNQQQQQTNTQQNQVQANSHDHGANNAKRMRMSGPNQGNNATGNQQQEFHQQQQMMFGQQGGGQQQQNFQQRF
Length451
PositionKinase
OrganismDanaus plexippus plexippus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Lepidoptera> Glossata> Ditrysia> Papilionoidea> Nymphalidae> Danainae> Danaini> Danaina> Danaus> Danaus.
Aromaticity0.09
Grand average of hydropathy-0.746
Instability index43.42
Isoelectric point8.78
Molecular weight52383.97
Publications
PubMed=22118469

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14120
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.05|      31|      40|     220|     259|       1
---------------------------------------------------------------------------
  220-  259 (42.56/51.71)	IDiWaigcifaELLTSEPIFHCRQEDIKTSNpYHHDQLDR
  270-  300 (56.49/36.42)	KD.W.......EDIRKMPEHATLVKDFKRSN.YQNCSLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.01|      14|      40|     377|     390|       2
---------------------------------------------------------------------------
  377-  390 (26.70/14.12)	ARQNQQ...QQQTNTQQ
  419-  432 (25.82/13.43)	ATGNQQ...QEFHQQQQ
  433-  449 (22.48/10.84)	MMFGQQgggQQQQNFQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.54|      31|      35|     140|     170|       3
---------------------------------------------------------------------------
  107-  132 (24.68/12.17)	.........HDLWhiiKFH..RAAKANKKSVMVPKGM
  140-  170 (57.28/36.96)	ILD.GIHYLHSNW...VLH..RDLKPANILVMGEGPE
  176-  208 (40.58/24.26)	IADmGFARLF.NA...PLKplADLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14120 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNRRITSEQAMQDPYFSEDPLPTQDVFAGCPIPYPKREFLTDDDQEDKSDSKARQNQQQQQTNTQQNQVQANSHDHGANNAKRMRMSGPNQGNNATGNQQQEFHQQQQMMFGQQGGGQQQQNFQQRF
325
451










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRMRMS
2) QQNFQQRF
3) QQQEFHQQQQM
405
444
423
411
451
433