<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14119

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEVLYSIDVEGEIKQNDWLTEGKCCCCLSCQNLMCICKQSTSGSDKEDAAGKFNVIYEVIVFDLDKPWEFFTVMTSPVSVTCMTWDRTGTRLLITDMDGQCQVWQMEDFFINKWKLLGKSSIPGEEILAMAWFHTGVQINFNPEKRDAVTYTEKFLRSKFTPTLTQFGGQPLDGWLAVTETGLISVGVINQQDQTIMTAQASLGGSHLRLSLATIAHTGTGEVMVATADGQLSSTIQCFLVTVRVTQSAVKVLAKASSSLYMKSQMDYGAQDSQKMMVSHIQFLNAESSDTLILCCGSQGYSCLEVWQLIDQHIPLNKLFQMSSGPDTAYKIPKWMHKATIPHASYLSAIAGPTLPMSKTFMETGFSPYIAVAYRDSTIKLIHRYTHQVIHTYFDALGAANQSISPTKRQKLTIHASNMIQTLSGCGLIALHDGKVSVLRVYNMRDGLMAMNPSYVCLLLEYAMVTGQDWWDAMLAVKQNTIDGISQKLTENYFKQTYSMQDVVSIRLVALKVALYSSANNGHQRAMDYHARLVLQSITALFRGLLRPKSANQQEKTPAEKLGALCKTTDGNLENILLNLEIEDFLIDSRKRDKSQGAEESALQSLQPLIQWVADFTLHLLATIPMYQSYSSFPGSSLLTDRSLLNTLRELLVIVRVWGIISPSCLPVFTTSSTDCLAHLFKVVTKAWQCCKEGGGVECDDALLDECCLLPSKIVIPSMNQSFRLDDSGYSIFTQPSSQMFSLGEEPEFMYNRKKLKFPFLSDVLTESQQNHDIIRQVHLGARPSDAVRRCTRCGGYSLIKSLGKSPIMKSWEARWRKNCLCGGLWKVEK
Length830
PositionTail
OrganismMizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Bivalvia> Autobranchia> Pteriomorphia> Pectinida> Pectinoidea> Pectinidae> Mizuhopecten.
Aromaticity0.09
Grand average of hydropathy-0.075
Instability index43.47
Isoelectric point6.98
Molecular weight92715.98
Publications
PubMed=28812685

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14119
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.30|      13|      24|     314|     326|       1
---------------------------------------------------------------------------
  314-  326 (23.96/17.82)	IPLNKLFQMSSGP
  341-  353 (23.34/17.14)	IPHASYLSAIAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.63|      47|     361|     385|     445|       2
---------------------------------------------------------------------------
  385-  431 (80.63/78.67)	YTHQVIHTYFDALGAANQSISPTKRQKLT...IHASNMIQTLSGCGLIAL
  462-  511 (75.99/45.76)	YAMVTGQDWWDAMLAVKQNTIDGISQKLTenyFKQTYSMQDVVSIRLVAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.21|      33|     201|      74|     108|       4
---------------------------------------------------------------------------
   74-  108 (58.18/41.89)	MTSPVSVtcMTWDRTGTRLLITDMDG.QC.QVWQMED
  277-  311 (52.03/30.45)	MVSHIQF..LNAESSDTLILCCGSQGySClEVWQLID
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14119 with Med16 domain of Kingdom Metazoa
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