<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14085

Description Protein kinase domain
SequenceMNSRNVGGSSNNNNNNNPNRPAWLQQYDLIGKIGEGTYGLVFLARTKSQPNRGKCIAIKKFKQSKDGDGVSPTAIREIMLLREISHENVVKLVNVHINPADMSLYLAFDYAEHDLYEIIRHHREKVNQSINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGEEQGVVKIADFGLARIYQAPLKYLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGVEVKATPNPFQLDQLDKIFKVLGHPTQEKWPTLVNLPHWQSDQQHIQGHKYDNPGLYSVVHLSQKSPAYDLLSKMLEYDPRKRITAAQALEHEYFRIDPLPGRNALVPCQPGEKVVNYPARPVDTTTDFEGSTSVQGSQSVSSGNAVSGSGVAASVVAPRPVPRPMPPMVGMQRMPGQGMTAFNLASQAGMPSGMNPGGIPMQRAASQAHQQQQMRRKDPGMGMTGYPPQQKSRRF
Length478
PositionKinase
OrganismMacleaya cordata
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Papaveraceae> Papaveroideae> Macleaya.
Aromaticity0.08
Grand average of hydropathy-0.439
Instability index40.67
Isoelectric point9.34
Molecular weight53277.31
Publications
PubMed=28552780

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14085
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.32|      18|      20|     413|     431|       1
---------------------------------------------------------------------------
  413-  431 (32.32/18.87)	GMQR.M.PGqGMTAFNLASQA
  432-  451 (27.00/11.55)	GMPSgMnPG.GIPMQRAASQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.06|      18|      38|     346|     365|       2
---------------------------------------------------------------------------
  346-  365 (26.14/22.89)	NALVPCQPGEKVVNyPaRPV
  387-  404 (30.91/16.79)	NAVSGSGVAASVVA.P.RPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      19|      20|     221|     240|       6
---------------------------------------------------------------------------
  221-  240 (30.52/24.53)	VDMWAVGCIFaELLTLKPLF
  243-  261 (33.03/21.63)	VEVKATPNPF.QLDQLDKIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.85|      14|      22|     265|     280|       7
---------------------------------------------------------------------------
  265-  280 (22.57/19.68)	GHPTQEkwPTLVNLPH
  290-  303 (27.28/15.28)	GHKYDN..PGLYSVVH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14085 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PCQPGEKVVNYPARPVDTTTDFEGSTSVQGSQSVSSGNAVSGSGVAASVVAPRPVPRPMPPMVGMQRMPGQGMTAFNLASQAGMPSGMNPGGIPMQRAASQAHQQQQMRRKDPGMGMTGYPPQQKSRRF
350
478










Molecular Recognition Features






MoRF SequenceStartStop




1) KCIAIKKF
2) MTGYPPQQKSRRF
54
466
61
478