<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14083

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMILFTKYNQLGIDIAQVLVPTIFLLNFKETSLHKGGLHHISWFQFLPFESDLSPLPEKGVKGEQKDAATLLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGMHNPDEKIKLWLFLPGRHSSVVEAAQAAVSKLRVVGSGFWLSPGDSEEVAAALSQALRNCVERALRGMSYLRYGDVFARCHPFSQSEITFRRVHPTVEFVFAATEEAIFVHVIISAKHIRTLSGHDLERVVKRRSSSKYGERLPVIVAPHGMRGRLTGCCPSDLVKQVYFSSSKVRALNGFTVLGIPLHVAQASGNQLRGQSCYVEVTLGCRGNGAEKGDQKQGSGDHFRVLERTFIYPAEAVLVPVIRTASARSSLKRFWLQNWVGTPLFGSTFSMYCSGFEGAGRIESVDGSRTESNGIYSQQSYDSSSDSNSSSISSISSTSSDSDYRMTSTVGDLEADADSLTCRQSGLSSNDQFENDGYKQVSKRPRLGMTESFGGAGTVINATTEAYKSDFCSVEVNNSVNDLFGSLWDWEDDDRGGGVDIHILLSDFGDFGDLFENDALPFGEPPGTAESQALIFSVPDCGEVIGSPCTGGMDVTDQMLLPVLGFSPFESLNPAPPAVTEEFPSKTQDFTKDSRFSDPGSYYSAPPTGEFEHLSKAEAIMTFAPEYRAVETAASELSSSIFSSPYLPRSRKVESSHSSSNAYIYGAVPPSPCLNVPDEKPGIVNAKAGSGRHDANPILHSKKYYTHIESWKHQHDKRLLACNNSNASCEGVTPPSFSGFNSTTPVNSVERKKADGTVEAGHFLLSLKTTLATEVECIMFQASMCRTRHMLLSSCNLGPTGLNRLTGSNVSDQLRGDQNTTPDKISSKYEVKKKESIPVRIAGDIDGGMLDGPVSAPVGVWRSVGVPKGAKTTSSPSIDNTSFAHNAFNEEGMVTYGQRQPLQELLDGMTLLVQQATSFVDVALDADYGDGPYGWLALQEQCRRGFSCGPSTVHAGCGGLLATGHSLDIAGVELLDPISANVHASSVISLLQSDIKVALKSAFGNLDGPLTVTDWCKGRSQSGDAVTISDGYSVDSTVGEAKDSSSSVTLAGGEPISPSQSSGGSSCLKVSSAMDGTRVDEASQRRLNQEICNSESEQQMSSSRLRPTLVVLPLPAILVGYQDDWLKTSTSSLQLWEKAPLEPYALPKPMTYYVLCPDIGLLTSAAADFFQQLGTVYETCKLGTHSPQNMGQTEVVSGKWSSSGFVLIDCPESMKIESGSTPFMGSISDYLLALSNNWDLKSFLKSLSNVIKALRVGSNSTMQQKEGSSGPTTVIYVVCPFPEPLAVLQTLVESSTALGSIVLSSDKERRSLLRTQVGKALSCSAAVDEASISNVLTLSGFSIPKLVLQIVTVEAILRVTSPALNELVLLKEIAFTVYNKARRIARSPYNDTSQSSGTSGRSQSTLMHISSPIQGMWKDCVTPRITGSSLSREGELDASLRWDNTWQTSRAGGLSCDPNRSGENSFQDDMRYSFEPLFILAEPGSMEQGISPTVLGNAVTESSRPSTDDNSGGFMQTSTSSGCADAGASSLLDGSEADGFGSSHPKTASLHCCYGWTEDWRWLVCIWTDSRGELLDSHIFPFGGISSRQDTKGLQCLFVQVLHQGCQILSCSSPDIGPTKPRDIVITRIGSFYELERQEWQKAIYSVGGNEVKKWPLQLRRSVPDGISASSNGSSLHQQEMSLIQERTLPSSPSPSMYSPQTKSSSFIKGGLGQTNTRKQLMGGQAAVDSSRGMFQWVQSISLVGVSIDHSLHLILQADTSFPGGTGTQGGSGTGPSNGYLEGFNPVKSIGSTSSSYVLIPSPSMRYLPPTPLQLPTCLTSESPPLAHLLHSKGSSIPLSTGFVVSKAVPSIRTDSRSTMKEEWPSILSVNLVDYYGGTNMIQEKMVRGSTKQNRNLSSDSRDHEIETHLILETLAAELHALSWMTVSPAYLDRRSALPFHCEMVLRLRRLLHFADKELSQQLDKAQV
Length1995
PositionKinase
OrganismMacleaya cordata
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Papaveraceae> Papaveroideae> Macleaya.
Aromaticity0.07
Grand average of hydropathy-0.247
Instability index52.04
Isoelectric point5.69
Molecular weight215679.90
Publications
PubMed=28552780

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14083
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     290.86|      68|      68|     314|     381|       1
---------------------------------------------------------------------------
  312-  342 (33.56/13.97)	......................................CR.G.NGA..EKGDQKQGSGDHFRVLERTFIYPAE
  343-  411 (103.43/61.02)	A.VLVPVIRTASARSSLKRFWLQNWVGTPLFGSTFSMYCS.GfEGA..GRIESVDGSRTESNGIYSQQSYDSS
  412-  478 (86.70/49.75)	SdSNSSSISSISSTSSDSDYRMTSTVG.DLEADADSLTC.rQ.SGL..SSNDQFENDG.YKQVSKRPRLGMTE
  483-  535 (67.16/36.60)	A.GTVINATTEAYKSDFCSVEVNNSV.NDLFGS.............lwDWEDDDRGGGVDIHILLSDF.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     504.74|     117|     122|    1389|    1506|       2
---------------------------------------------------------------------------
 1202- 1307 (120.32/61.61)	..............TVYETCKLGTHSPQN.........M.GQTEVVSGKwSSSGFVLIDC.PESMKIESGSTP.....FMGSisdyllALSNNWDLKSFLKsLSNVIK.......ALRVGSNSTMQQKEG.SSGPTTVIYVVCP..
 1319- 1387 (36.21/12.59)	..VESSTALGSIVLSSDKERRSLLRTQVGK........AlSCSAAVDEA.SISNVLTLSGfSIPKLVLQIVTVeailRVT..................................................................
 1389- 1505 (200.09/105.78)	PALNELVLLKEIAFTVYNKARRIARSPYND........T.SQSSGTSGR.SQSTLMHISS.PIQGMWKDCVTP....RITGS......SLSREGELDASLR.WDNTWQ.......TSRAGGLSCDPNRSGENSFQDDMRYSFEPLF
 1510- 1625 (148.13/75.83)	PGSME....QGISPTVLGNAVTESSRPSTDdnsggfmqT.STSSGCADA.GASSLLD.GS.EADGF..............GS......SHPKTASLHCCYG.WTEDWRwlvciwtDSRGELLDSHIFPFGGISSRQDTK.GLQCLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     209.21|      57|      64|     693|     756|       3
---------------------------------------------------------------------------
  693-  730 (58.70/28.36)	...........................GAVPP...SPCLNVPDEKP.GIVNAKAGSG.....RHDAN..PILHSKK
  731-  795 (82.44/58.52)	YYTHIESWKHQHDkrllACNNSNasceGVTPP...S.FSGFNSTTPvNSVERKKADG.....TVEAG..HFLLSLK
  798-  855 (68.08/36.31)	LATEVECIMFQAS....MCRTRH.........mllSSC.NL...GP.TGLNRLTGSNvsdqlRGDQNttPDKISSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.27|      21|      56|     976|     996|       4
---------------------------------------------------------------------------
  976-  996 (39.28/25.14)	GPSTVHAGCGGLLATGHSLDI
 1035- 1055 (39.99/25.75)	GPLTVTDWCKGRSQSGDAVTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.15|      41|     540|     536|     583|       5
---------------------------------------------------------------------------
  536-  581 (61.55/48.94)	GdFGDlFENDAlPfgEPPGTAE...SQALIFS....VPDCGEVIGSPCTGGMD
  592-  639 (67.60/30.85)	G.FSP.FESLN.P..APPAVTEefpSKTQDFTkdsrFSDPGSYYSAPPTGEFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.24|      24|     540|    1151|    1174|       6
---------------------------------------------------------------------------
 1151- 1174 (42.87/27.00)	DWLKT..ST..SSLQLWEKAPLE.PYALP
 1666- 1691 (31.00/17.18)	EWQKAiySV..GGNEV.KKWPLQlRRSVP
 1692- 1717 (33.37/19.14)	DGISA..SSngSSLHQQEMSLIQ.ERTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.63|      13|     228|     668|     685|       8
---------------------------------------------------------------------------
  650-  662 (22.38/15.76)	FAPEYRAVETAAS
  673-  685 (23.24/ 7.45)	YLPRSRKVESSHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      12|     105|    1718|    1729|      10
---------------------------------------------------------------------------
 1718- 1729 (27.08/14.59)	SS.....PSPSM.YSPQT
 1821- 1838 (17.10/ 6.02)	SSsyvliPSPSMrYLPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.16|      46|     140|     120|     168|      11
---------------------------------------------------------------------------
  120-  168 (63.18/52.23)	SSVVEAAQAAVSKLRVVgSGFWLSpGDSEEVAAALSQALR..NC.VERALrG
  263-  311 (69.97/42.68)	SDLVKQVYFSSSKVRAL.NGFTVL.GIPLHVAQASGNQLRgqSCyVEVTL.G
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14083 with Med13 domain of Kingdom Viridiplantae
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