<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14080

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVRRAAEDSFLSLNDLVEKSKTSEQSDSEKKISLLKYIVKTRQRMLRLHVLAKWCQQVPLVQYCQQLASTLSSHDTCFTQTADSLFFMHEGLQQARAPTYDVPSAIEVLLSGSYEKLPKCIEDMGVQSALAGDQQKSALKKLDTLLRSKLLEISLPKEISEVKVSDGTVVVLVEGEFKVLLTLGYRGHLSLWRILHLELLVGERSGLVKLEESRRHALGDDLERRMAAAENPFVILYSILHELCVALIMDTVIRQVQGLRQGRWKDAIRFELISDGNTGQGGNAGSLQMGQDGEADLAGLKTPGLKILYWLEFDKSTGGSDPGCPFIKIEPGQDLQIKCLHSTFVIDPQTGKEGEFSLDLSCIDVEKLLLRAISCNRYTRLLEVHRELGKNCQISQAANDVLLQCHGDKSDMDMKKKDIKSSSREYGGNEVLRVRAYGSSYITLGINIRNGRFFLQSSRNILAPSVLLECEDALNQGGMTAAEVFINLRSKSILHLFASIGRFLGLQVYEQGFTAVKIPKNILNGSGLLLMGFPQCGSSYYLLLELDKDFKPLFSLLETQPDTSGKSHFVSESNHVIRFNKIDISQMQMLEDELNLSLLDWEKLMSSLPNVGGTNQTSEHGLLTEFGLDASTQIAGSPQSSFSSVVDEVFELEKGISMPPFPVQNHLSSSFGTSPVSQFGSVQMNHQWVKAGITSPKWEGGLQHPQVNSFTKVPSGGSHFNNLYQSNNLKLIQSSSVNSLSSSPGRSQSIQKLSASKSDQDLASLRSPISVEVGSPMDEDQVRLLNESSKELVPSSRSSRLLSPLRPTVPRVSASSTKPNGPRVSPSVHITGSRADGTGSWITSPVCQAPESGVSNNSSRDLVPKHNKNPRKRSISDVLRLIPSLQGEEVSTVCKRRKISDSAHCYPPGSQAVCSSDVIGKSEVYTYGNLLAEANKGNAPSNIYVTALLHVVRHCSLCIKHARLTSQMAALEIPYVEEVGFRTPSSNIWFRLPFAREYSWQNICLRLGRPGSMYWDVKINDQHFRDLWELQKGSTNTPWGCGVRIATTSDVDSHIRYDPEGVVLSYRSVEADSIKKLVADLRRLSNARLFALGMRKLLGVRTDDKLDESSANTESKIPVGSKGAVEVVDKMSEQMRKAFRIEAVGLMSLWFSFGPGVVARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGGEVASLLDCIRLTAGPLLALAAATRPARAGPASAAPNIPASASSIPKQNAFVQSQGVLPSSSSSNVTQTTTSPSGNPIANNGVGPLGSHGLHNAAMLAVAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFSVDMRCFAGDQVWLQPATPPKEGRTVGGSLPCPQFRPFIMEHVAQELNGLEPTFAGGQNTVGLVNSNNPNPSSASNLPNANRVNLASAGGISRPTSVAGLSRMGNALMASSNLAAVSSGLPIRRTPGTGVPIHVRGELNTAFIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGTLLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQSQASAQEELTHAEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQAQGGEMAPAQKPRIELCLENHAGLSMDENSENSSSTSKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPRVSFLGMEGSHGGRACWFRLEDWEKSKQRVTRTVEMNGTTGGDVTQGRLRLVADSVQRTLQLCLQGLRDGSAVTASTGTT
Length1823
PositionTail
OrganismMacleaya cordata
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Papaveraceae> Papaveroideae> Macleaya.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index47.85
Isoelectric point8.30
Molecular weight199008.41
Publications
PubMed=28552780

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14080
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.49|      49|     146|    1258|    1324|       1
---------------------------------------------------------------------------
  802-  852 (79.33/33.45)	SKELVPSSRSSRLLSplRPTVPRVSASSTKPNGPRVSPSVHITGSRA.DGTG
 1261- 1310 (81.16/57.62)	SQGVLPSSSSSNVTQ..TTTSPSGNPIANNGVGPLGSHGLHNAAMLAvAGRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.25|      15|      18|     674|     688|       2
---------------------------------------------------------------------------
  674-  688 (30.03/11.78)	F..PVQNHLSSSFGTSP
  711-  727 (20.22/ 6.05)	WegGLQHPQVNSFTKVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.25|      19|     148|     577|     599|       3
---------------------------------------------------------------------------
  577-  599 (29.44/30.69)	SGKSHFvsesNHVIRFNKIDISQ
  728-  746 (34.80/24.41)	SGGSHF....NNLYQSNNLKLIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.89|      55|     233|    1440|    1499|       4
---------------------------------------------------------------------------
 1440- 1499 (86.18/66.57)	AGLSRMGNALMASSnlaAVSSGLPIRRtPGTGVPIHVRGELNTAFIGLGDDGGyGGGWVP
 1674- 1728 (95.71/57.47)	AGLSMDENSENSSS...TSKSNIHYDR.PHNSVDFALTVVLDPAHIPHINAAG.GAAWLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.36|      40|     233|     368|     407|       5
---------------------------------------------------------------------------
  368-  407 (69.63/47.58)	EFSLDLSCIDVEKLL..LRAISCNRYTRLLEVHRELGKN..CQI
  604-  647 (60.73/40.45)	EDELNLSLLDWEKLMssLPNVGGTNQTSEHGLLTEFGLDasTQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.85|      20|      69|     231|     250|       6
---------------------------------------------------------------------------
  231-  250 (35.65/24.86)	LGDDLERRMAAAENP.FVILY
  302-  322 (31.20/20.72)	MGQDGEADLAGLKTPgLKILY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.45|      48|     571|    1162|    1242|       7
---------------------------------------------------------------------------
 1167- 1237 (64.25/100.16)	GPGVVarfvvewesgkegctmhvsPDQLWP.......HTKFLEDFINGGEVASLLDCIrltAGPLLALAAATrPARAG
 1311- 1365 (86.19/44.97)	GPGIV...................PSSLLPidvsvvlRGPYWIRIIYRKNFSVDMRCF...AGDQVWLQPAT.PPKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.11|      16|      17|     906|     922|       8
---------------------------------------------------------------------------
  906-  922 (28.49/21.07)	VCKRRKISDSaHCYPPG
  926-  941 (26.62/14.86)	VCSSDVIGKS.EVYTYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.74|      15|      71|     445|     468|       9
---------------------------------------------------------------------------
  445-  459 (26.22/ 6.27)	LRVRAY..GSSYITLGI
  544-  553 ( 2.36/ 6.65)	..MGFPqcGSSY.....
 1018- 1032 (30.15/ 9.24)	LRLGRP..GSMYWDVKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.85|      16|      17|     976|     991|      16
---------------------------------------------------------------------------
  976-  991 (26.21/16.22)	RLTSQMAALEIPYVEE
  995- 1010 (29.65/19.37)	RTPSSNIWFRLPFARE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14080 with Med14 domain of Kingdom Viridiplantae
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