<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14080

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSTLVRRAAEDSFLSLNDLVEKSKTSEQSDSEKKISLLKYIVKTRQRMLRLHVLAKWCQQVPLVQYCQQLASTLSSHDTCFTQTADSLFFMHEGLQQARAPTYDVPSAIEVLLSGSYEKLPKCIEDMGVQSALAGDQQKSALKKLDTLLRSKLLEISLPKEISEVKVSDGTVVVLVEGEFKVLLTLGYRGHLSLWRILHLELLVGERSGLVKLEESRRHALGDDLERRMAAAENPFVILYSILHELCVALIMDTVIRQVQGLRQGRWKDAIRFELISDGNTGQGGNAGSLQMGQDGEADLAGLKTPGLKILYWLEFDKSTGGSDPGCPFIKIEPGQDLQIKCLHSTFVIDPQTGKEGEFSLDLSCIDVEKLLLRAISCNRYTRLLEVHRELGKNCQISQAANDVLLQCHGDKSDMDMKKKDIKSSSREYGGNEVLRVRAYGSSYITLGINIRNGRFFLQSSRNILAPSVLLECEDALNQGGMTAAEVFINLRSKSILHLFASIGRFLGLQVYEQGFTAVKIPKNILNGSGLLLMGFPQCGSSYYLLLELDKDFKPLFSLLETQPDTSGKSHFVSESNHVIRFNKIDISQMQMLEDELNLSLLDWEKLMSSLPNVGGTNQTSEHGLLTEFGLDASTQIAGSPQSSFSSVVDEVFELEKGISMPPFPVQNHLSSSFGTSPVSQFGSVQMNHQWVKAGITSPKWEGGLQHPQVNSFTKVPSGGSHFNNLYQSNNLKLIQSSSVNSLSSSPGRSQSIQKLSASKSDQDLASLRSPISVEVGSPMDEDQVRLLNESSKELVPSSRSSRLLSPLRPTVPRVSASSTKPNGPRVSPSVHITGSRADGTGSWITSPVCQAPESGVSNNSSRDLVPKHNKNPRKRSISDVLRLIPSLQGEEVSTVCKRRKISDSAHCYPPGSQAVCSSDVIGKSEVYTYGNLLAEANKGNAPSNIYVTALLHVVRHCSLCIKHARLTSQMAALEIPYVEEVGFRTPSSNIWFRLPFAREYSWQNICLRLGRPGSMYWDVKINDQHFRDLWELQKGSTNTPWGCGVRIATTSDVDSHIRYDPEGVVLSYRSVEADSIKKLVADLRRLSNARLFALGMRKLLGVRTDDKLDESSANTESKIPVGSKGAVEVVDKMSEQMRKAFRIEAVGLMSLWFSFGPGVVARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGGEVASLLDCIRLTAGPLLALAAATRPARAGPASAAPNIPASASSIPKQNAFVQSQGVLPSSSSSNVTQTTTSPSGNPIANNGVGPLGSHGLHNAAMLAVAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKNFSVDMRCFAGDQVWLQPATPPKEGRTVGGSLPCPQFRPFIMEHVAQELNGLEPTFAGGQNTVGLVNSNNPNPSSASNLPNANRVNLASAGGISRPTSVAGLSRMGNALMASSNLAAVSSGLPIRRTPGTGVPIHVRGELNTAFIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGTLLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQSQASAQEELTHAEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQAQGGEMAPAQKPRIELCLENHAGLSMDENSENSSSTSKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPRVSFLGMEGSHGGRACWFRLEDWEKSKQRVTRTVEMNGTTGGDVTQGRLRLVADSVQRTLQLCLQGLRDGSAVTASTGTT
Length1823
PositionTail
OrganismMacleaya cordata
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Papaveraceae> Papaveroideae> Macleaya.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index47.85
Isoelectric point8.30
Molecular weight199008.41
Publications
PubMed=28552780

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP14080
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.49|      49|     146|    1258|    1324|       1
---------------------------------------------------------------------------
  802-  852 (79.33/33.45)	SKELVPSSRSSRLLSplRPTVPRVSASSTKPNGPRVSPSVHITGSRA.DGTG
 1261- 1310 (81.16/57.62)	SQGVLPSSSSSNVTQ..TTTSPSGNPIANNGVGPLGSHGLHNAAMLAvAGRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.25|      15|      18|     674|     688|       2
---------------------------------------------------------------------------
  674-  688 (30.03/11.78)	F..PVQNHLSSSFGTSP
  711-  727 (20.22/ 6.05)	WegGLQHPQVNSFTKVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.25|      19|     148|     577|     599|       3
---------------------------------------------------------------------------
  577-  599 (29.44/30.69)	SGKSHFvsesNHVIRFNKIDISQ
  728-  746 (34.80/24.41)	SGGSHF....NNLYQSNNLKLIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.89|      55|     233|    1440|    1499|       4
---------------------------------------------------------------------------
 1440- 1499 (86.18/66.57)	AGLSRMGNALMASSnlaAVSSGLPIRRtPGTGVPIHVRGELNTAFIGLGDDGGyGGGWVP
 1674- 1728 (95.71/57.47)	AGLSMDENSENSSS...TSKSNIHYDR.PHNSVDFALTVVLDPAHIPHINAAG.GAAWLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.36|      40|     233|     368|     407|       5
---------------------------------------------------------------------------
  368-  407 (69.63/47.58)	EFSLDLSCIDVEKLL..LRAISCNRYTRLLEVHRELGKN..CQI
  604-  647 (60.73/40.45)	EDELNLSLLDWEKLMssLPNVGGTNQTSEHGLLTEFGLDasTQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.85|      20|      69|     231|     250|       6
---------------------------------------------------------------------------
  231-  250 (35.65/24.86)	LGDDLERRMAAAENP.FVILY
  302-  322 (31.20/20.72)	MGQDGEADLAGLKTPgLKILY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.45|      48|     571|    1162|    1242|       7
---------------------------------------------------------------------------
 1167- 1237 (64.25/100.16)	GPGVVarfvvewesgkegctmhvsPDQLWP.......HTKFLEDFINGGEVASLLDCIrltAGPLLALAAATrPARAG
 1311- 1365 (86.19/44.97)	GPGIV...................PSSLLPidvsvvlRGPYWIRIIYRKNFSVDMRCF...AGDQVWLQPAT.PPKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.11|      16|      17|     906|     922|       8
---------------------------------------------------------------------------
  906-  922 (28.49/21.07)	VCKRRKISDSaHCYPPG
  926-  941 (26.62/14.86)	VCSSDVIGKS.EVYTYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.74|      15|      71|     445|     468|       9
---------------------------------------------------------------------------
  445-  459 (26.22/ 6.27)	LRVRAY..GSSYITLGI
  544-  553 ( 2.36/ 6.65)	..MGFPqcGSSY.....
 1018- 1032 (30.15/ 9.24)	LRLGRP..GSMYWDVKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.85|      16|      17|     976|     991|      16
---------------------------------------------------------------------------
  976-  991 (26.21/16.22)	RLTSQMAALEIPYVEE
  995- 1010 (29.65/19.37)	RTPSSNIWFRLPFARE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14080 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLASLRSPISVEVGSPMDEDQVRLLNESSKE
2) VPSSRSSRLLSPLRPTVPRVSASSTKPNGPRVSPSVHITGSRA
774
806
804
848










Molecular Recognition Features






MoRF SequenceStartStop




NANANA