<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14072

Description Mediator complex
SequenceMQRYSAASCSAGVSSGAVGGQSARDTNRADSSFALSGFSLNQRRQSQLTPYKLKCEKEPLNNRLGPPDFYPQSPNCPEETLTRESLQHGYKETVDGLEEAREISLSQLGTFTRPVVLKCKEAIRKRHRAINESRAQKRKAGQVYGVPLSGSLLTKPCAFPEQRPCSEDFRKKWIEGLSQQHKRLRSLADHVPHGYRRRSLFEVLIRQNVPLLRATWFIKVTYLNQVRPGSTSVSPVAPDKTQLARSELWTKDVIEYFQYLLDEFFTKDGSLSTAQRRDQSPSMLLAGLVQNRGDSGASTLLDGEGPSVHFKWWYMVRILHWHHAEGLLIPSHIIDWILNQLQEKESFDALQLLLPIISSIIESIALSQTYARSLVEVVVRYIQEPLPGASDLVDNSHRAYTASALVEMLRYLIVAVPDTIVALDCFPIPPCILSDAVNGTSFFPNMVSEDAEKAQCGPRDFATMYSGKGRDAHSKFLSLDYIVSSIQKRADNLAKAVSPGVQGHGVAKAVQALDKALILGDVRGAYNVLFDDLCDGGVEEGWIAEVSPGLRSSLKWIGTVSGSFVCSVFFLCEWAACDFRDCRTAVPHDLKLTGTKDFSQVYMAALLLKLKMEDMCSISVQFKTSSALGTNSLAKGASQHDSFSGKTVVEDVSFPRKKSKIFGEGKDSSDSFKSPGPMHDILVCWIDQHEVDKGEGCKRLQLLIMELILSGIFHPQAYVRQLIVSGVMDRNETPLDLDRQKRHYRILKQLPGPCLREALEEARIAVVPISLETMCVYSNERHLVLHGFLSGRCVHSKNGNTTVGASKKRKDIPASGRDGPSPTSLDHWKSFDSASSPLPVRNVKTKFQVAELKAAISNFLHLPNSYSISTDIQADESQGSLKRPIGSIGNKIDVSEGPPSCEECRRAKRQKTSEESSSFLQGFSSNALDDEDSWWVRKGPKSLEPLKVDPPKLTKHPSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDNKISCPHHRTGMEGETPKSMDEIRTANLTNVVTIGKALKHLRLLEKRTITLWLVNYVKQLIEGTAKTARKMGQCTGPFSPVDDRAASQWKLGEDELSAILYLLDVSYDLISAIKFLLWLLPKVLTSTNSTVYGGRNTPLLPKNMENHACEVGEAFLLSSIQRYENVVVAADLLPDVLSATMLRVAAGTVSSSPAFVYARNLLKKYGNVVSVARWEKSFKAMCDQRVLSELESGRTLDGEFGFSPGIPAGVEDPDDYFRQKISSRLPRAGPSMKEIVQRQVEEAVHYFYGKERKLFAAATQKGPGVEKWDDGYQRAQKIVLGLMECIRQNSAAAQEGDPSLVASAVSAIVGNVGPTVAKMPDFTLSSNYPKFPSAISSLNCARCIVHLHITCLCLLKEALGERHSRVFEIALAAEAFSVVAGAFAPVKAPRSQFQLSPEVHDSNTNLSNDILNNSAKVLVGRAAKAAASVSSLVIGALVHGVVSLERMVTVFRLREGLDILQLIKSGRTSSNGISRTMGAFKVDNSIEVYVHWFRVLVGNCRTISDGLVVELLGEPYILALSRMQRMLPLSLVFPPAYSILGMVIWKPYIPNNNISTREEVQLSLASAIGDAIRHQPFRDVCLRDTYAFYDLLASDVGDSEFAAMLELQSLDKHLKTMAIVPLRARLFLNALLDCKMPESMLTQDDGTWVPGHGEPKAQHAENEKRLLDQLVHVLDTLQLAKFHWQWVELRLLLNEQVLIEKIEASSSTSVVEAIRSLSPHADNFALSESENNFTEIVLTRLLVRPDAAPLYSEVVHLLGRSLEESLLLHAKWFLAGHDVLFGRKSIRQRLVNIAQLRGLSTKVQFWKPWGWSSSVAEQSASRGDKRKFEATSLEEGEVVEEGIDLRRSGKTNSQISDAEGLTEKALVELVLPCIDRSSSDSHNTFASELIKQMNNIEQHLNALTRAASKQAGSVPPGVEGAANKSNSRKSIRGGSPGLGRRLTGAAADSAPPSPAALRASMWLRLQFLLRLLPIIYADREPSGRNMRHMLASVILRLLGSRVVHEDADMSFYPTTQSSPAPAKREVVDSPMEASAAASLDLSGESLFEWFLSVFHGLLSSCKPSWLKPKSSSKSTVKSSRDFSVFDREVAESLQNDLDRMQLPETIRWRLQSAMPVLPPYLPRFISCQPPAVSTAAIAALQSSSSMSSVPCGAGFIHHGNSNPSSQRNPVVGLTPRPTVNNVPGKSKQQLALLQLDQQEMEMDPWTLLEDGTGSSGCPTSSTSSSSSNGSSSMVVGGLGLGLGSSSDHSSLSSSNNLKACSWLKGAVRVRRTELTYIGAVDDDS
Length2316
PositionKinase
OrganismMacleaya cordata
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Papaveraceae> Papaveroideae> Macleaya.
Aromaticity0.07
Grand average of hydropathy-0.217
Instability index48.35
Isoelectric point8.57
Molecular weight254596.77
Publications
PubMed=28552780

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14072
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.61|      40|     140|     471|     521|       1
---------------------------------------------------------------------------
  263-  302 (64.95/28.53)	EFFTKDGSLSTAQRRDQSPSMLLAGLVQNRGDSGASTLLD
  475-  514 (65.66/51.22)	KFLSLDYIVSSIQKRADNLAKAVSPGVQGHGVAKAVQALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     461.73|     159|     321|    1350|    1524|       2
---------------------------------------------------------------------------
 1350- 1524 (227.13/182.58)	KMPDFTLSSN....YPKF..PSAISSLNCARCIVHL.HItcLCLLKeaLGERHSRVFEI.ALAAEAFSV....VAGAFAPVKAPRSqfqLSPevHDSNTNLSNDiLNNSAKVLVGR..AAKAAASVSSLVIGALvhGvVSLERMVTVFR..LREGLDILQLIKSGRTSSNGISRTMGafkVDNSIEVYVHW
 1667- 1841 (234.60/143.41)	KMPESMLTQDdgtwVPGHgePKAQHAENEKRLLDQLvHV..LDTLQ..LAKFHWQWVELrLLLNEQVLIekieASSSTSVVEAIRS...LSP..HADNFALSES.ENNFTEIVLTRllVRPDAAPLYSEVVHLL..G.RSLEESLLLHAkwFLAGHDVLFGRKSIRQRLVNIAQLRG...LSTKVQFWKPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     351.05|     112|     142|     640|     780|       3
---------------------------------------------------------------------------
  640-  765 (182.14/153.46)	HDSFSGKTVvedvsFPRKKSKIFGEGKDSSDSFKS..PGPMHDILVCW..IDQHEVDKGEGCKRLQLLIMEL..ILSGIFH.PQAYVrqliVSGVMDRNETPLDLDRQ..KRHYRI.LKQLPGPClrealEEARIA
  786-  907 (168.92/93.97)	HGFLSGRCV.....HSKNGNTTVGASKKRKDIPASgrDGPSPTSLDHWksFDSASSPLPVRNVKTKFQVAELkaAISNFLHlPNSYS....ISTDIQADESQGSLKRPigSIGNKIdVSEGPPSC.....EECRRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.97|      38|     883|      26|      67|       4
---------------------------------------------------------------------------
   26-   67 (56.86/53.79)	TNRADSSFaLSGFSLNQrRQSQLTPYKLKCEK..EPLnnRLGPP
  912-  951 (67.11/45.23)	TSEESSSF.LQGFSSNA.LDDEDSWWVRKGPKslEPL..KVDPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.98|      27|      29|    1970|    1997|       5
---------------------------------------------------------------------------
 1970- 1997 (45.48/31.33)	LGRRLTGAAADSaPPSPAALR...ASMWLRL
 2000- 2029 (40.50/23.12)	LLRLLPIIYADR.EPSGRNMRhmlASVILRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     242.55|      80|    1972|      69|     152|       6
---------------------------------------------------------------------------
   69-  152 (118.65/90.50)	FYPQSPNCPEETlTRESLQHGYKETVD.GLEEAREiSLSQ..LGTFtRPVVLKCKEAIRKrHRAINESRAQKRKAGQVYGVPLSGSL
 2043- 2125 (123.89/77.28)	FYPTTQSSPAPA.KREVVDSPMEASAAaSLDLSGE.SLFEwfLSVF.HGLLSSCKPSWLK.PKSSSKSTVKSSRDFSVFDREVAESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.36|      20|      28|     368|     387|      14
---------------------------------------------------------------------------
  368-  387 (33.38/26.11)	QTYARSLVEVVVRYIQEPLP
  398-  417 (31.98/24.66)	RAYTASALVEMLRYLIVAVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     205.64|      63|     314|    1904|    1969|      15
---------------------------------------------------------------------------
 1904- 1969 (100.02/80.57)	PCIDRSSSDSHNTFAselIKQMNNIEQHLNALTRAASKQAGSVPPGVEGAANKSNSRKSIRGGSPG
 2209- 2271 (105.63/76.97)	PTVNNVPGKSKQQLA...LLQLDQQEMEMDPWTLLEDGTGSSGCPTSSTSSSSSNGSSSMVVGGLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14072 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CGAGFIHHGNSNPSSQRNPVVGLTPRPTVNNVPGKSKQQLALLQL
2) DIQADESQGSLKRPIGSIGNKIDVSEGPPSCEECRRAKRQKTSEESSSFLQG
3) EMDPWTLLEDGTGSSGCPTSSTSSSSSNGSSSMVVGGLG
4) GNTTVGASKKRKDIPASGRDGPSPTSLDHWKSF
5) TRAASKQAGSVPPGVEGAANKSNSRKSIRGGSPGLGRRLTGAAADSA
2183
871
2233
799
1936
2227
922
2271
831
1982










Molecular Recognition Features






MoRF SequenceStartStop




1) LLRLLP
2) YLPRFI
2000
2152
2005
2157