<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14060

Description Uncharacterized protein
SequenceMDNQIPLSVPRRPLPPQRAVSSGALSQPEPPSRPGLPSRLSDVRSVSQPSKLVDLTTEREPERGNDGPAVLGIQERRTGIALGQGQEGQEGDRERPAKRMKLGRDVIHSDKINNEDISKADIRHEGETLPCLPTSGAPKTQTKLPRRGQRGGESSARASNGLEPPPIATRLPPPKTAADFAPWTGNHPEDQLNEAIIKSGYSDKGAGTGQSETNSAKPAIWQNLSSKNNMGLQTLSYLFTQVMEKRQALGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPDIPLRKQSRTIPHGIRGKLLMEQCLSKDIPMQRAVWLAKCVGANELRAFKRRGVSGAAAATGEMKWIREWTAHVEQFLDGVVALCGQQDWQTKMNYAVKLSATFYSEKLLDTEHFLEWVASSFIEASIDTLPVWIIMAQIFWKDVTRLCKRGRRLARNILERLSHLSQVPSDASRTLKVRLRKLLAVLATASKRCLIMPRTWVAYGQLLISSLELEQTPGGIIESIVKRNERLARPLAIPANNAASPFLDLYTALDATSLEVDVTALASMCKSKIPETPVLVSALFDWATSPYRHGSKRRYLAAGIINTLDGSGDDTTSLALRYLEANKSGTIDRINDCYLLIAELVRLGSFAVGRYMQWLSSSGALYAGDQAKTITGLLFCLPTDSLPAHLVGLRAALLDRIEVQREVEAKGTELVDLFENALETSASYSDLEHAITTSTLSARLRVVQHVRTSMNRVAGGGSEVSVNTFCLLRTALEAAPDVAALSKLADISLATDSPALLATIADTVAMHMDALAALGELQHLVNELIERYAALRTQQPLDRTLILALTRLVRPLSHRQGLEELLLNDLAICEQQSSMQVCSPASDSIIGMHASALETDSDIDAVFASGNSMDDNLLHRVFDRVLQRAQKPQHEFAGSTSKIHEWLSQLRLVGGSSFDQLVNNHITSTFKDGIEDSAHASAAVTALVASGCSSLQSIAESGRRSNSTKAACLALDIILRLRPVLLSLHTTEKYRFCVEAEQYLHTAAHSLIELLCKACHDSNFAAEDSRILDVLVTYSVKHKELARSISKHAEQTATGLSNFGRMTQALLLRGSPQLSRDSINMQTVIRLANPLSVQFVVGTLEYLAKKGDAEGSDAEAAVKDNLIEAIEDGSEVWSLLLDAVSNPVQRALHNWAREQLLLVASSGVESSEPEAFDAQTRRIVGRYVDVLSATKSSTAGIDNAATWSILAEKLSKVDTRLRSLDILASSQRLIRQALCETLEIILTIIVLGVETSEEDAEVEKQARASLLQSLCSLGTQSLAYTSPSSAEYAMDVAALITNNLAMDVLQNVAHSMSTERALNAHSESIVGNGSASAETWLALAFSPSSGTQQQRALAKHANHQGGTAGARPGGLNHATGSSHQQRAWSLPFGATRQPVEMKTTPYAIRRWEIMPDSAPVMGENDTSLSLGLFGARKA
Length1461
PositionKinase
OrganismHortaea werneckii EXF-2000
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Hortaea.
Aromaticity0.05
Grand average of hydropathy-0.198
Instability index44.29
Isoelectric point6.83
Molecular weight158917.93
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14060
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.55|      15|      15|     768|     782|       1
---------------------------------------------------------------------------
  768-  782 (23.93/14.97)	LSKLAD.ISLATDSPA
  784-  799 (20.62/11.78)	LATIADtVAMHMDALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.83|      14|      15|     443|     456|       2
---------------------------------------------------------------------------
  443-  456 (24.35/14.69)	RLSHLSQVPSDASR
  461-  474 (21.48/12.03)	RLRKLLAVLATASK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.07|      12|      15|     292|     305|       3
---------------------------------------------------------------------------
  292-  305 (17.02/19.26)	IPhgIRGKLLMEQC
  310-  321 (23.05/15.63)	IP..MQRAVWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.10|      13|      15|     800|     812|       4
---------------------------------------------------------------------------
  800-  812 (21.70/11.43)	ALGELQHLVNELI
  817-  829 (22.40/12.02)	ALRTQQPLDRTLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     347.53|      82|      83|    1123|    1204|       5
---------------------------------------------------------------------------
 1123- 1204 (123.70/82.09)	VVGT.LEYL.AKKGDAEGSDAEAAVKDNL.IEAIED.GSE..VWSL..LLDAVSNPVQ.....RALHNWAREQLLLVASSGVESSEPEA.FDAQTR
 1206- 1290 (92.60/59.22)	IVGRyVDVLsATKSSTAGID.NAATWSIL.AEKLSKvDTR..LRSL..DILASSQRLI.....RQALCETLEIILTIIVLGVETSEEDAeVEKQAR
 1301- 1379 (88.85/56.46)	GTQS.LAYT.SPSSAEYAMDVAALITNNLaMDVLQN.VAH..SMSTerALNAHSESIV.....GNGSASAETWLALAFSPSSGTQQQRA.......
 1380- 1434 (42.39/22.29)	........L.AKHANHQGGTA.GARPGGL.NHATGS.SHQqrAWSL..PFGATRQPVEmkttpYAIRRW...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.55|      29|      94|     142|     183|       6
---------------------------------------------------------------------------
  148-  183 (41.54/32.20)	GQRGGESSARAsnGLEPPPiatRLPPPKTAADfaPW
  246-  274 (53.00/29.68)	RQALGKCTAPS..TFKPPP...RVTVTDTKRE..AW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.63|      28|      83|     863|     895|       7
---------------------------------------------------------------------------
  863-  895 (44.52/43.47)	QVCSPASDSI.IGMHASALETdsdidAVFASGNS
  948-  976 (45.11/30.73)	HITSTFKDGIeDSAHASAAVT.....ALVASGCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.29|      36|     147|     903|     944|      14
---------------------------------------------------------------------------
  701-  745 (50.03/24.37)	FENALEtSASYSDLEHAITTSTLsarlrvvqHVRTSMNRVAGGGS
  905-  940 (64.27/41.57)	FDRVLQ.RAQKPQHEFAGSTSKI........HEWLSQLRLVGGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.30|      19|      20|      10|      28|      15
---------------------------------------------------------------------------
   10-   28 (36.02/21.00)	PRRPLPPQRAVSSGALSQP
   31-   49 (35.28/20.40)	PSRPGLPSRLSDVRSVSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.82|      16|     132|     195|     210|      17
---------------------------------------------------------------------------
  184-  207 (20.90/10.16)	TGNhpedqlneAIIKSGYSDKGAG
  208-  231 (22.92/11.77)	TGQsetnsakpAIWQNLSSKNNMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14060 with Med12 domain of Kingdom Fungi
Unable to open file!