<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14059

Description Uncharacterized protein
SequenceMDNQIPLSVPRDLPPSQRTVSSGALSQLEPPSRPGLPSRLSNVRSVSQPSKLVDLTTEGDPERGNDGPPMLGVQERETGVLVERGQEGQEGEEERPAKRLKTGRDVGHSEKINNEDVAKAGIRHEGEALPRLPPSGAPKTQIKLPRRGQRGGESSARASSGLEPPPIATRLPPPKTAADFAPWTGNHPEDQLNEAIIKSGYSDKGAGTGQSESNSAKPAIWQNLSSKNNMGLQTLSYLFTQVMEKRQALGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPDIPLRKQSRTIPHGIRGKLLMEQCLSKDIPMQRAVWLAKCVGANELRAFKRRGVSGAAAATGEMKWIREWTAHVEQFLEGVVAMCGQQDWQTKMNYAVKLSATFYSEKLLDTEHFLEWVTSSFIEASIDTLPVWIIMAQIFWKDITRLCKRGRRLARNILERLSHLSQLHSDASRNLKARLQKLLAVLATVSKRCLIMPRNWVTYGELLISSLELEQTPGDIIESIIKRNERLARPLAIPANNAASPLLDLYTTLDSTSLEVDVTALARMCKSKIPETAVLLSALFDWATSPYRHGSKRRYLAAGIINALDDSGDDSTSLALRHLEANKSWTTDRINDSYLLIAELVRLGSFAVGRYMQWLSSSGALYAGNQAKTITGLLFCLPTDSLPAHLVGLRSALLDRIEVQREAEAKGTDLVDLFEHALQTSALCNELEHAITTSTLSARLRVVQHARTSMDRIAGGESEVSVDTFCLLRTALEAAPDVAALSKLADISLATDSPALLATITDTVAMHMDAFAALGELQRLVNELIERYAALRTQQPLDRTLILALTRLVRPLLHRQGLEELLLSDLAICEQQSSMQVCSPASDSIIGMHASALDTDSDIDAVFASGNSMDENLLHRVFDRVLQRAQKPQHEFFGSISKLHGWLSQLRLVGGSSFDQLVHSHITSTFKDCNEESAHAAAAVTALVASGCSSLQSIAEAGRTSSTTKAACLALDIILRTIPVPPSLHTTEKYRFTVEAEQYLHTAAHSLIELLCKACHDSNFAAEDSRILDVLVTYSVKHKELARSFSKHAEQTATGLSNFGRMTQALLLRGSPQLSRDSINMQTVISLANPLSVQFVVGTLEYLAKKGDAEGSDAEAAVKDNLIEAIEDGSEVWSLLLDAVSKPVQRALHNWAREQLLLVASSGVESSEPEAFDAQTRRIVGRYLDVLSATKCSIAGIDNAATWSILAEKLSKVDTRLRSLDILASSQQLIRQALCETLEIILSIIVLGVETSEEDAEAEKQARASLLQSLCSLGTQSLAYTCPSSAEYAMDVAALITDNLAMEVLQNVAHSMSTERALNVHIESIVGKGSASAEDWLALAFSPSSGTQQQRALAKHANHQGGAAGARPGGLNHATGSSHQQRAWSLPFGATRQPVEMKTTPYAIRRWEIMPDSAPVMGENDTSLSLGLFGARKA
Length1461
PositionKinase
OrganismHortaea werneckii EXF-2000
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Hortaea.
Aromaticity0.05
Grand average of hydropathy-0.200
Instability index44.84
Isoelectric point6.26
Molecular weight159198.24
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14059
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.71|      13|      18|      62|      76|       1
---------------------------------------------------------------------------
   62-   76 (21.32/16.04)	ERGNDGPPmlGVQER
   83-   95 (24.39/11.84)	ERGQEGQE..GEEER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     379.60|      90|      90|     734|     823|       2
---------------------------------------------------------------------------
  584-  640 (59.46/30.78)	.............................A.AGIINALDDSGD.DSTSLALRHLEANKSWTTDRINDS..........YLLIAEL.VRLGSFAVGRYMQ.......
  643-  723 (105.34/60.47)	SSSGALYAGNQAkTITGL.LFCLPTDSLPA.HL.VGLRSALLDrIEVQREAE...AKGTDLV....DL..........FEHALQT.SALCNEL.EH..AI.TTSTL
  734-  823 (143.68/85.28)	RTSMDRIAGGES.EVSVD.TFCLLRTALEA.APDVAALSKLAD.ISLATDSPALLATITDTVAMHMDA..........FAALGEL.QRLVNELIERYAAL.RTQQP
  837-  915 (71.12/38.33)	RPLLHR.QGLEE.LLLSDlAICEQQSSMQVcSP..............ASDS..I.......IGMHASAldtdsdidavFASGNSMdENLLHRVFDR..VLqRAQKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     155.18|      27|      90|     157|     183|       3
---------------------------------------------------------------------------
  119-  146 (31.31/15.16)	KA..GIRHEG.EAL.PRLPPsgaPKTQIK..L.PR
  157-  183 (50.17/29.03)	RA..SSGLEP.PPIATRLPP...PKTAAD..FAPW
  194-  221 (29.46/13.80)	EAiiKSGYSD.KGAGTGQSE...SNSAKP...AIW
  227-  255 (20.87/ 7.49)	KN..NMGLQTlSYLFTQVME...KRQALGkcTAP.
  256-  274 (23.38/ 9.33)	.....STFKP.PP...RVTV...TDTKRE....AW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.61|      81|      83|    1123|    1204|       4
---------------------------------------------------------------------------
  400-  428 (21.36/ 6.49)	........................VTSSFIEASIDTLPVWIIMAQIFWK..DITR.............................................
 1123- 1204 (132.13/84.16)	VVGT.LEYL.AKKGDAEGSDaEAAVKDNLIEAIEDGSEVWSLLLDAVSK..PVQRALHNWAREQLLL.............VASSGVESSEPEA.FDAQTR
 1206- 1290 (83.12/47.73)	IVGRyLDVLsATKCSIAGID.NAAT..............WSILAEKLSKvdTRLRSLDILASSQQLIrqalcetleiilsIIVLGVETSEEDAeAEKQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.95|      10|      17|     438|     447|       7
---------------------------------------------------------------------------
  438-  447 (17.33/12.58)	RNILERLSHL
  456-  465 (16.62/11.71)	RNLKARLQKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14059 with Med12 domain of Kingdom Fungi
Unable to open file!