<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14041

Description Uncharacterized protein
SequenceMTDRLTQLQDAIDNMLTLQFTLQIYNQTKHPYADIPGQLSQAPKETKTETTQLTNGDAATQQPNGPSQPQQQAQQEGPEEEKPPVPDTPENFERALRELAQAMVLQEQQMEVLINSLPGLERSEAEQVQRMKALEAELREVEAERVKAEEERVKMLDALGGVMVGARRVP
Length170
PositionMiddle
OrganismHortaea werneckii EXF-2000
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Hortaea.
Aromaticity0.02
Grand average of hydropathy-0.829
Instability index56.02
Isoelectric point4.58
Molecular weight19088.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU366036

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14041
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.58|      16|      20|     121|     136|       1
---------------------------------------------------------------------------
   93-  112 (18.75/ 8.46)	ERALRELAQAMvlqeQQMEV
  121-  136 (26.64/14.65)	ERSEAEQVQRM....KALEA
  144-  158 (23.19/11.94)	ERVKAEE.ERV....KMLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.51|      10|      18|      61|      70|       2
---------------------------------------------------------------------------
   61-   70 (20.08/ 8.46)	QQPNGPSQPQ
   81-   90 (19.43/ 8.00)	EKPPVPDTPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14041 with Med21 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KHPYADIPGQLSQAPKETKTETTQLTNGDAATQQPNGPSQPQQQAQQEGPEEEKPPVPDTPENFERALRELA
2) MEVLINSLPGLERSEAEQVQRMKALEAELREVEAERVKAEEERVKMLD
29
110
100
157










Molecular Recognition Features






MoRF SequenceStartStop




NANANA