<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14032

Description Uncharacterized protein
SequenceMGDGRAGGANRPAWLQQYELIGKIGEGTYGLVFLARLKPSHPAPGRRGPPIAIKKFKQSKEGDGVSPTAIREIMLLREINHENVVKLVNVHINHADMSLYLAFDYAEHDLYEIIRHHREKLSSSINPYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGEGDEHGIIKIADFGLARIYQAPLKPLCDNGVVVTIWYRAPELLLGGKHYTSAVDMWAVGCIFAELLTLKPLFQGVEAKNTPNPFQLDQLDKIFKVLGHPTVEKWPTLANLPWWQNDQQHIQGHKYDNPGLHNIVHLPPKSPAFDLLSKMLEYDPRKRITAAQALEHEYFRMEPLPGRNALLPSQPGEKIVPYPVRPVDTTTDFEGTTSLQPTQPPSGNAPPGGQSVARPMPRQMPQQPMVGGMPRVAAGANMAAFNAASQAGMAGLNPGNIPMQRGAGGQSHPHQLRRKADQGMGMQNPGYPQQKRRF
Length471
PositionKinase
OrganismSorghum bicolor (Sorghum) (Sorghum vulgare)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Andropogonodae> Andropogoneae> Sorghinae> Sorghum.
Aromaticity0.08
Grand average of hydropathy-0.434
Instability index44.12
Isoelectric point9.37
Molecular weight52378.63
Publications
PubMed=19189423
PubMed=29161754

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14032
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.80|      50|     146|     136|     189|       2
---------------------------------------------------------------------------
  136-  189 (75.37/65.84)	QLLNGLNY....LHSnwIIHRDLK.PS.NILV.MGEGDEHGIIKIADfGLARIYqAPLKPL
  281-  337 (74.43/47.73)	QHIQGHKYdnpgLHN..IVHLPPKsPAfDLLSkMLEYDPRKRITAAQ.ALEHEY.FRMEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.19|      27|      28|     410|     437|       3
---------------------------------------------------------------------------
  410-  437 (43.63/26.39)	AAGANMA.AFNAASQAGMAGLNPGnIPMQ
  440-  467 (48.56/25.65)	AGGQSHPhQLRRKADQGMGMQNPG.YPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.87|      28|     303|      37|      68|       4
---------------------------------------------------------------------------
   37-   66 (44.53/22.64)	LKPSHpaPGRRGPPIAIKKFKQSKEGDGVS
  343-  370 (49.33/19.96)	LLPSQ..PGEKIVPYPVRPVDTTTDFEGTT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14032 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPLPGRNALLPSQPGEKIVPYPVRPVDTTTDFEGTTSLQPTQPPSGNAPPGGQSVARPMPRQMPQQPMVGGMPRVAAGANMAAFNAASQAGMAGLNPGNIPMQRGAGGQSHPHQLRRKADQGMGMQNPGYPQQKRRF
335
471










Molecular Recognition Features






MoRF SequenceStartStop




1) HPHQLRRKADQ
2) NPGYPQQKRRF
3) PIAIKKFK
445
461
50
455
471
57