<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP14003

Description Cyclin-dependent kinase 8/11
SequenceMTTAVMMDYEFKMKTQQERAKVEDLFEYEGCKVGRGTYGHVYKAHRKEGNDPKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKATKKPVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIRKMPEHHTLTKDFKRSNYASCSLIKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGEKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNNQQQNQQGNNAQQQQPGNAQQMQQAGGQGGSGMDHNGAKRVRLTGPNGHPNNQQGGGMTQQEYHQQQQQQQQQQQQQQQQNQQAQMMFNNAQQGGFQQRY
Length520
PositionKinase
OrganismAnopheles albimanus (New world malaria mosquito)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.08
Grand average of hydropathy-1.045
Instability index58.45
Isoelectric point8.65
Molecular weight60697.59
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP14003
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     183.30|      20|      20|     378|     397|       1
---------------------------------------------------------------------------
  378-  397 (43.45/12.19)	QQQQQQQQQQQQQQQQQ..QQQ
  399-  418 (43.45/12.19)	QQQQQQQQQQQQQQQQQ..QQQ
  419-  440 (29.72/ 6.17)	QNNQQQNQQGNNAQQQQpgNAQ
  467-  486 (31.61/ 7.00)	NGHPNNQQGGGMTQQEY..HQQ
  487-  505 (35.08/ 8.52)	QQQQQQQQQQQQQQNQQ..AQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.94|      16|      26|     245|     267|       3
---------------------------------------------------------------------------
  245-  262 (22.79/35.23)	EDIKtSNPYHHdQLDRIF
  274-  289 (31.16/15.97)	EDIR.KMPEHH.TLTKDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP14003 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PNKRITSEQAMQDPYFSEDPMPTADVFAGCPIPYPKREFLTDEDQDDKGEKRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNNQQQNQQGNNAQQQQPGNAQQMQQAGGQGGSGMDHNGAKRVRLTGPNGHPNNQQGGGMTQQEYHQQQQQQQQQQQQQQQQNQQAQMMFNNAQQGGFQQRY
326
520










Molecular Recognition Features






MoRF SequenceStartStop




1) HNGAKRVRLTGP
2) QQEYHQQQQQQQQQ
455
480
466
493