<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13995

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGVRASLPTNHDRDHGQFVNGNGNHAPQSAPDRHNGISTGAGAGSSNGASSMVNGKDNGDAANAALVQRTSSNPSRMNDLPDEIKHITDGFIPLSVLLSRLAQKTHNQLADEIIALAKMPAPTSAVNGNSSHALTTTDDTSPENLSKKTRLLNFIQDKHAEWVKATVIARWSRNASSVSKLIDIHSLFRNEQKRYFDIIAILADQRWSLAFARLPNPDLQTALHVLSTGTAPWMPDLGYIDPPPLTPKEQLQWIENLNTLLSIRLNLDDYDNLPYHFRDYTIDSGRVTFKVPGEFEVDLTIADEDFEKQFWFIDFRFDFTPAPSELSDSLRIYLEGKVNEVLEKDGLKGCYKFLHELVLTHKITEYVRQAFELNRGRWVDTLKVERLNRALAIQYWVGRYPPEGPKSWIILGVNSGKKANAPEDPKATSYLTLRWFRDNKEVKDVEIPLDDSIISTEDLLNHVIGKHIEYILGSIHSKLKPNGRFAKREAGLALDIHKSDPARSSLRVQIGYRHYLTVKISPITGLFSMEPQSGTSWKGEQSLNWRSKDPIQDGVTCVENVRCHYVVDEIIRRGKSIGWFVCKAPVKAEAVKEALKSREVGQLVWLRRRGWTDQWYLIVNLSLSGDTWCLTGVYTPPTGDPRISSFTKLPLSSYMPNFKDKFFSNLTIFTAAIISHITDMRALHQRRVKHSVYGGINYALPPTLKIPAILLRLSDVLRPPQSNEPGRRIASWAHDYVQVIFRGASGPSTKPQIPDRHLMTVNGTGENASVQKESLHIFLEARIRVSEPSRFGLLKGHVERDVAFSRRLGVFALRLEEKIGDSVLDTLTHRLQAIDRLADCIDAIRQSDRDIHCEEITLTKIVVSYTDRIKPEAGGTAQPHGHRWKAALELGPNGTKLLFEKGNPQLRALDLFRHLVTSDLRCEKLPFFLSSTLPIHRALDAIEDAWAGFEMNNQGRVEIFAAHMDWLDIRYYLPPTRNSHVPRRLTLQIRLRKRHCGVQWEMCRHEPGPLHNPDDEFKAVLDKVWNADNRGWRSLVDSAACEPDHRVADLIRAADESIRRLMTRSPTLLKQNQPKGQIPAKNPTQAMYHKAMAAVFTGTTKLVNTSAIPAGVSKSAAVSLLHDHDFFLRCEPHYVSHRTLPPTEASSSSSAAAAKSEYQLPRDLEPVGEPAVKLYEVVDHVPNPVWSSSVVSNEEFVDFKDGLWVRIRSPLAVVMETRWTIRERKKQKTTTSENGKGEGGGEREEEGGELELVEDVMISCSKLLMGIVKGQVDTNWREIHRRIAARLVEDAKRAAGEVKE
Length1302
PositionTail
OrganismDaldinia sp. EC12
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Daldinia.
Aromaticity0.08
Grand average of hydropathy-0.430
Instability index41.62
Isoelectric point8.57
Molecular weight146640.99
Publications
PubMed=28078400

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13995
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     268.49|      69|     155|     711|     787|       1
---------------------------------------------------------------------------
  473-  520 (60.85/20.08)	ILGSIHSKLKP..NG..RF.AKREAG...LALD....IHK..SDParsSLRVQIGYRHYLTV.......................
  711-  786 (106.90/54.98)	ILLRLSDVLRPPQSN..EP.GRRIAS...WAHDYVQVIFRgASGP...STKPQIPDRHLMTVngtgenASVQKESLHIFLEARIR
  863-  936 (100.75/40.29)	IVVSYTDRIKPEAGGtaQPhGHRWKAaleLGPNGTKLLFE.KGNP...QLRALDLFRHLVT.......SDLRCEKLPFFLSSTLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.25|      33|      33|       3|      35|       2
---------------------------------------------------------------------------
    3-   35 (61.98/36.55)	NGVRASLPTNHDRDHGQFVNG..NGNHAPQSAPDR
   37-   71 (50.27/28.37)	NGISTGAGAGSSNGASSMVNGkdNGDAANAALVQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.98|      38|     418|     574|     613|       3
---------------------------------------------------------------------------
  574-  613 (63.80/51.30)	RRGKSIGWFVCK.APVKAEAVKEALKSreVGQLVW.LRRRGW
  995- 1034 (67.19/47.25)	KRHCGVQWEMCRhEPGPLHNPDDEFKA..VLDKVWnADNRGW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|       9|     154|     245|     256|       4
---------------------------------------------------------------------------
  245-  256 (15.51/16.19)	PPLTPKeqlQWI
  403-  411 (21.60/12.47)	PPEGPK...SWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.15|      15|      33|     270|     285|       7
---------------------------------------------------------------------------
  270-  285 (25.58/23.35)	DDYDNlPYHFRDYTID
  306-  320 (29.56/21.38)	EDFEK.QFWFIDFRFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.10|      25|     220|     838|     862|      15
---------------------------------------------------------------------------
  838-  862 (44.68/34.20)	RLADCIDAIRQSDRDIHCEEITLTK
 1048- 1072 (41.42/31.11)	RVADLIRAADESIRRLMTRSPTLLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13995 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGVRASLPTNHDRDHGQFVNGNGNHAPQSAPDRHNGISTGAGAGSSNGASSMVNGKDNGDAANAALVQRTSSNPSRMNDLPDEI
1
86










Molecular Recognition Features






MoRF SequenceStartStop




NANANA