<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13991

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMMPGVVMMENGVRAPLPTNHDRDGHFVNGNGGLPPQSNGTLAGAGAASSNGTTTMTNGNGAGDGVIAAQPQRVNTNPSRMNDLPDEIKHITDGFVPLGLLLSRLAQKTHNQLADEIVALSKMPAPTPAVNGNAAHGGAIADDTSTENLGKKARLLNFVQERHAEWVKAAVITRWSRNAHNVSKLIDLMWVINSQRITYDRTIHTMAENKRNLTFARLPNPDLGTAHQVLSSGTAPWMPEFAYIKPSPLTAKEQLRWLENMNTLLSIRLNLEDYDNLPDQFRDYTIDSGRVTFKVPGEFEVDLMIADEDFDKQFWFIDFRFDFQPAPSELTDLLRMHLEGRVNEVLGKDGLSGCYKFLHEFVLTHKITEYTRQAIELSRNRWVDTLKIERLNRAMSIQYWVGRHPPEGPKNWIILGVHSGRKPNAPEDHKSTSHLTLRWFRDSKEVKDFEILLDDAVISTETLLNRVIGKHIDFILGSIYSKIRAHGRFANEEAGLGLDIQKEDPAQSSLRMQLGYDRYMTIRISPTIGTISIKPQFNITWKGEQKLNWYSKDPIQDGLACLESVRCQYVVDEISRHGKSSGWFVCRSPIKQEAVKAAMSLKEMGQLLWVKRHGWTDQWYLMVNLSLSGDKWFLIEVNDRPSGEPQISFTKLPLGSYAPNFGDEFFSNLTLYTASMISHMTDLRALHRRRIRNISHDGVNYSLPANMKVPSVFVRLSDILRQPQSTGSNKRLAPWAHDFVEITFRGVHSPSIWSYISDRNKSAAKGDGEKAASSDDSLRVLMDARLKVSDPSRFDLLQGHVERDVAFNKRLGVFALRLEEKVGYSILDVLSHRLQAIDKLADCIDAIRRSDRDIQCEDITLTKVVVTYTDRLKSESNTTAQPPGGRWKAILELRPDGIQLLFEKGNPQVRVLDLFRELINSDLRCQCLPFFLSGTIPVHRALDSIQNAWEDLEKNNQGRVEIFAASLDWFNIHYHLPGPNRNPHATRRLTMQAKLRERRGKFEWEVRRHEPGTTHAPDDEFKQTLDKVWNADGRMWRSLVNSAACTPDRIGNLLKAIDEAVRKLAMQSPTLLKQGQPKGHMQARSQAQAYHKQMAANRVRPSSHPQANSVVVLDD
Length1114
PositionTail
OrganismHypoxylon sp. CI-4A
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon.
Aromaticity0.08
Grand average of hydropathy-0.469
Instability index45.35
Isoelectric point8.79
Molecular weight126090.91
Publications
PubMed=28078400

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13991
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.77|      30|      33|     531|     563|       1
---------------------------------------------------------------------------
  531-  549 (26.99/12.95)	..............SI....KPQF...NITWKGEQ..KLNWY
  550-  583 (37.69/27.27)	SKDPI.QDGLAC....lesvRCQYvvdEISRHGKS..S.GWF
  585-  619 (38.08/22.80)	CRSPIkQEAVKAamSL....KEMG...QLLWVKRHgwTDQWY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     332.48|     104|     462|     221|     346|       2
---------------------------------------------------------------------------
  226-  346 (161.92/140.71)	HQVLSSGT....APWMPEFAYIKPSPLTAKEQLRWLENMNTLLSIRLNLEDydnlpdqfrDYTIDSGRVTFKVPGEfevdlMIADEDfDKQFWFIDFRFDFQPaPSELtDLLRMHLEGRV..NEVLG
  418-  454 (31.04/ 6.62)	.....SGR....KPNAPE.DHKSTSHLT....LRWFRDSKEVKDFEILLDD............................................................................
  720-  811 (139.52/78.09)	RQPQSTGSnkrlAPWAHDFVEITFRGVHSPSIW...........................SYISDRNKSAAKGDGE.....KAASSD.DSLRVLMDARLKVSD.PSRF.DLLQGHVERDVafNKRLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.60|      18|      28|      28|      55|       3
---------------------------------------------------------------------------
   35-   53 (27.46/31.27)	PQSNGTLAGAGAASSNgTT
  127-  144 (32.15/13.03)	PAVNGNAAHGGAIADD.TS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.30|      30|      32|     968|     999|       4
---------------------------------------------------------------------------
  968-  999 (48.74/35.75)	WfNIHYHLPGPNRNPHATRRLTMQaKLRERRG
 1003- 1032 (56.56/32.37)	W.EVRRHEPGTTHAPDDEFKQTLD.KVWNADG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.65|      22|      29|     891|     912|       7
---------------------------------------------------------------------------
  891-  912 (37.74/24.22)	ELRPDGIQLLFEKGNPQVRVLD
  921-  942 (40.91/26.89)	DLRCQCLPFFLSGTIPVHRALD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.50|      24|     201|     164|     190|       8
---------------------------------------------------------------------------
  164-  190 (39.78/35.73)	EWVKAAVITRWSRNAHNVSKlidLMWV
  359-  382 (42.72/29.28)	EFVLTHKITEYTRQAIELSR...NRWV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13991 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMQSPTLLKQGQPKGHMQARSQAQAYHKQMAANRVRPSSHPQANSVVVLDD
2) DEIVALSKMPAPTPAVNGNAAHGGAIADDT
3) GVVMMENGVRAPLPTNHDRDGHFVNGNGGLPPQSNGTLAGAGAASSNGTTTMTNGNGAGDGVIAAQPQRVNTNPSRMNDLPDEI
1064
114
4
1114
143
87










Molecular Recognition Features






MoRF SequenceStartStop




NANANA