<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13988

Description Uncharacterized protein
SequenceMTSRPPMAVPQRQPQRTLSGSGLSQSPTHQRTLSQQFLPQSPIRKSESFSESSTDLGDVAQGRFNTLPRRGGSRLKLELANDGIEHPGFSESPQNLDAISVNKAFTPSRVMSINDVSDAGDLTPRTSRCQTADEDSVPLPMPLRRTRFVVPAKRPEPSSTCTNTTPKKDARPKPFVLEAPSIAPRYPNMGKPEPTGKTRSKDTATRACTDLCVGYADFYPWTGSHPEDQFSDSIIRHGFFDKSPAQSTQEPASAKAPLFPAMKHKSGLHTLSTIFTGILNQRRHSGQITSPSTFKPPPRVTLTDTKREIWLKDLANPAISLRRLSRTIPHGIRGKVLLEQCLNKNVPTDRAVWLAKCVGANEIRAFKRKGVNGIFVMGGEAKWIRDWTVFVEQFVESVTNAFNENDWKTKVTYAIRLATHLYAEHLLDRDHYMDWLVAGLENSNQAKLPMWLLTIQIYWKDILKLRRHGRRLVSAIVSHHSSIYYHPDRDILLPLSSRLQHLVESLLMTSPENFINPGIWLKYRDSLLESTVSSNKESRSSAFKSIDSRNDYLTSSNAKSQPALRSIVVQLLDNIHRTPLDSAIPKQLWKTSENKLSIVRTVLEWCTSLYRPGIAKVYIAASLLRSSSDLDVDVTRAILDFLDADPLQENARKQLVYHLVSELIRSGHFSTPQYIQWLIARGGLSNAAETSRDGPCVTRLLVEIPLDSLTESMRNLRATLLRRTSFSVEDEARDMAIAISYVKSTLSVPLSPNDPTLHAKPLSLKKLSKRIELSSRALKTTISTWLSNDFVGGFAQSLQSGKGGVELPKTAFETVRTLLEAAQDFTMLETILKLTSASSNAELLACCVDTLNLHLTIFSATGAVKPLFHTFYGRLKIILEEQGVGARPLLASLANLAPRLTGSEDVATQLRNDLIRIDRSSVADASSPLSDNMATQLQDAESELSEQIEKLASYTSADRMTMERLFYAIIKKLQAYWGKEDERQRLCCILLTRLRVFDIHHFNELMRGFVQHIRKLSSRPPISQLFPPLISSGCLSLAILFATVPRNQNQTTQLQSSAVGSASIYRQELLQMLMMPFSPSAIMTSEDCYRFRIVQDHARYEYSKELMPLIHGALAEYSRNQQAAIRQPLDDKQTEEQILELLRDLVLIDPNAASQTVSIKSPDPKLSALIEAWTTKLLIPNGGGGQKSFEQVLELANEFTLPFCQVKLSLNLATDESNGPEASERLQSQFEQLSKALDNAIDANNIMWTGMLPSLSTEITQHMRNRAELRFLDIIPSLKNRPNDAQFNKDIHMAENLLTVIDSIFRGGSGSKVSPLSGALVDKLADLWEILASRANEYASLRSAVISHWLPLLFSYLTLYTSPSASALDMSKLPGGEIRGRALIVLAGLVQELDNHPTSNLGKQAFDIALALVDSLPEEARLQCVRAVKDVTADPRLRYLFSFAPNPAEDLMLAHREKPPPGINERRAMAMGMGMSMIPERLTPFIIRRWEILNEPTPNVGENDTSLSLTLFDARKIK
Length1518
PositionKinase
OrganismHypoxylon sp. CO27-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon.
Aromaticity0.07
Grand average of hydropathy-0.281
Instability index50.29
Isoelectric point8.92
Molecular weight169484.03
Publications
PubMed=28078400

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13988
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     460.09|     152|     181|     435|     615|       1
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  254-  327 (67.10/39.08)	........................................................................................AKAPLFpamkhksgLHTLSTIFTGILNQRRHSGQ.ITS........PSTFKPPPR.VTLTDTKR...................EIWLK...DLANPAISLRRLSRT
  364-  540 (233.46/218.25)	RAFKRKGVNGIFVMGGEAKWIRDWTVFVEQFVESV.....TNAFNENDWKTKVTYAIRLATHLYAEHLLDRDHYM.dWLVAGLENSNqAKLPMW........LLTIQIYWKDILKLRRHGRR.LVSAIVSH..HSSIYYHPDRdILLPLSSRlqhlvesllmtspenfinpGIWLKyrdSLLESTVSSNKESRS
  541-  673 (159.53/115.06)	SAFKSIDSRNDYLTSSNAKSQPALRSIVVQLLDNIhrtplDSAIPKQLWKTSENKLSIVRTVLEWCTSLYRPGIAkvYIAASLLRSS.SDLDVD........VTRAILDFLDADPLQENARKqLVYHLVSEliRSGHFSTPQ....................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.87|      33|      90|    1319|    1356|       2
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 1319- 1356 (50.55/38.59)	ALVDKLADLWEILASRAneyasLRSAVISHWLPLLFSY
 1411- 1443 (56.33/32.01)	ALVDSLPEEARLQCVRA.....VKDVTADPRLRYLFSF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.35|      19|      97|    1392|    1410|       5
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 1392- 1410 (33.39/17.13)	ELDNHPTSNLGKQAFDIAL
 1491- 1509 (32.96/16.83)	EILNEPTPNVGENDTSLSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.71|      45|    1013|       1|      48|       6
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    1-   48 (73.26/43.12)	MTSRPPmaVPQRQPQRTLSGSgLSQS...PTHQRTLSQQFLPQSPIRKSES
 1016- 1063 (73.45/34.65)	LSSRPP..ISQLFPPLISSGC.LSLAilfATVPRNQNQTTQLQSSAVGSAS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.94|      10|      16|     336|     345|       7
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  336-  345 (17.69/ 9.02)	VLLEQCLNKN
  352-  361 (19.26/10.37)	VWLAKCVGAN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.50|      14|      16|      96|     109|       8
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   96-  109 (23.69/14.49)	LDAISVNKAFTP..SR
  113-  128 (18.82/ 9.88)	INDVSDAGDLTPrtSR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13988 with Med12 domain of Kingdom Fungi
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