Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKQLDVCFDRVEKALGTLVDSIAKYHPSVAQVNDLGLADIELNKGLENLQTHQANYRRIQDLRAATASFDAQIKDTLRLLANTRKELVGARATIFPSDVPSYDINYDELLAYARRISKTTMPPAGTINSASTDAEAKNGEGSAMQTAAATPAGQTPNDTQPAVANGIQPQNQDPNSQPQSQPNTSITTPSGGNAATNLPEEMQMNMNPYTGFEFIPWPNEEQVRQGALVSLAFLAEQGIDPENYDPEEEKLRKKREEDEQKEAEERERQEREERERRAREEQARMRAQREKEQAEAYRRGSVMIGATGGPSQPGSASPVGEKKQFQFMADDDEDDDE |
Length | 338 |
Position | Middle |
Organism | Hypoxylon sp. CO27-5 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.975 |
Instability index | 50.24 |
Isoelectric point | 4.66 |
Molecular weight | 37516.71 |
Publications | PubMed=28078400 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13984 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 51.80| 18| 24| 83| 106| 1 --------------------------------------------------------------------------- 86- 106 (28.43/22.72) KELVG.AR...ATIFPsdvPSYDIN 108- 129 (23.37/ 6.23) DELLAyARrisKTTMP...PAGTIN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.92| 21| 22| 249| 270| 2 --------------------------------------------------------------------------- 249- 270 (30.37/19.85) EEKLRKKREEDEQKEAeERERQ 273- 293 (35.55/19.24) EERERRAREEQARMRA.QREKE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 67.16| 19| 24| 139| 160| 3 --------------------------------------------------------------------------- 139- 158 (29.83/23.60) NGEGSAMQTAAATPAGQtPN 166- 184 (37.33/18.01) NGIQPQNQDPNSQPQSQ.PN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 106.56| 26| 26| 33| 58| 4 --------------------------------------------------------------------------- 6- 27 (28.88/20.09) ..DVCFDRVE..KALGTLVDSIAKYH 33- 58 (41.47/31.92) VNDLGLADIELNKGLENLQTHQANYR 60- 85 (36.20/26.97) IQDLRAATASFDAQIKDTLRLLANTR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EQAEAYRRGSVMIGATGGP 2) FEFIPW 3) PGSASPVGEKKQFQFMADDDEDDDE | 293 213 314 | 311 218 338 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab