Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MATLDLTKEEFRALETTRLRLMQITSSIAGLKADVFASNPLPNLESLQNHADILESKIQSVIDVTSSMAEVFSRVAVHPSTNFPGRTQEMILLQLLRKKPEPDVATTMDEGRKLYAELVTAADPSGAAAAGGILKTAGKGPEEELETTWDSMRGCCEQRIMDYVTNEADDMYTEEERERGIESVRTGLRKVFDDEDEDEDEEEEEADDDVMEIDRPPPPPAPGIATQEVEGAPLESIVRFATRGEFVAR |
Length | 249 |
Position | Head |
Organism | Hypoxylon sp. CO27-5 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.522 |
Instability index | 46.31 |
Isoelectric point | 4.34 |
Molecular weight | 27562.42 |
Publications | PubMed=28078400 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13978 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.08| 21| 39| 22| 59| 1 --------------------------------------------------------------------------- 22- 42 (36.11/53.31) MQITSSIAGL..KADVFASNPLP 62- 84 (31.97/12.53) IDVTSSMAEVfsRVAVHPSTNFP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 74.14| 21| 39| 92| 112| 2 --------------------------------------------------------------------------- 92- 112 (36.42/22.76) LLQLLRKKPEPDVATTMDEGR 133- 153 (37.72/23.81) ILKTAGKGPEEELETTWDSMR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ADDDVMEIDRP 2) GIATQEVEGAPLESIVRFATR | 206 223 | 216 243 |
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