<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13976

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNDLPDEIKHITEGFIPLGLLLSRLAQKTHNQLLDEIAVLAKMPTSAPAINGNSSHTGASMDDNSTENLAKKTRLLNFVQEKHAEWVKAAVIAKWSRNAQSVSKLIDLVWLLRQQHEKYQAIIHAMAAIRYSSTLARLPNPDLRTALQVLSTGTAPWMPDFNYILPPPLTAKEQLQWIENINTLLSIRLNLEDYDTLPYHFQNYTIDSGRVTFKVPGEFEVDLTIADEDFSKQFWFIDFRFDFTPAPPELSEALRMHLESKVNEALEKDGLFGCYKFLHELVLTHKITEYFRQAFELIRGRWVDTLKVERLNRAMSIQYWVGRYPPEGPKSWIILGVNSGKKRGAFEDPKSTSYLTLRWFRDNKEVKDVDIPFDSVDISTEDLLNRVIGRHVAFILRSIHSKLKSNGRFTKREAGLALDIRENDPTQSSLKMQLGHAYYLTVGISSTTGMFAMKPQSAMTWKGEHRLNWQSKDPVQDGLICLEGVRCHYVVDEMIRRGRSTGWVVRKGPVKPDTVKEALSLREMGQLMWLQRRGWADQWYIMVSLSMSGDKWFLLEVNSQPNGEAKITSSAKLPLSSYAPNLEDKFFTNLTVFTAAMISHTIDLRTLHKRQIKHVPHDGVNFSLPANMKVPSVFIRLSDILRQPQSDKLHKRPANWAHDFVEIMFRGIRNPATRPQILDRDRTATNGTKEAGESTESPKESLYAFLDARLKVSDPARFGLLKGHVERDVAFSRALGIFALRLEARVGSTVLDTLAHRLQAIDKLADCVDAIRRSDRDIQCEEITLTKVVVTYTDRKKSDGEITAQPNSNRWKATLELSPDRIKLSFERGNPQLRALDFFRELINSDLRCEKLPFYLSSTLPIHRALDAVEDAWADLALNDRGRVEVFAAHLDWFNIHYTLPGLNRNPYALRRLTLQIRLRGRRESVEWELTREEPGPVKKPDDEFKQALDKVYNAEGRVWRSLVDSASSKTDHRVGDLIRAVDEAVRRLAMQSPTVLKPQPKGLVQKSQAQAVYHKQMATGRPRPQPQSGQVVVLDD
Length1037
PositionTail
OrganismHypoxylon sp. CO27-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon.
Aromaticity0.08
Grand average of hydropathy-0.423
Instability index43.19
Isoelectric point9.14
Molecular weight118444.10
Publications
PubMed=28078400

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13976
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.38|      83|     559|     293|     433|       1
---------------------------------------------------------------------------
  296-  394 (130.55/165.80)	ELIRGRWVDTLKVERLNRA...MSIQYWVGRYPPEGPKswiIL.....GVNSGKKRG.AFEDPKSTsyltLRWFRDNK.EVKDvdipfdsvdISTEDLLNRVIGRHVAF
  639-  731 (125.83/60.65)	DILRQPQSDKLHKRPANWAhdfVEIMFRGIRNPATRPQ...ILdrdrtATNGTKEAGeSTESPKES....LYAFLDARlKVSD.........PARFGLLKGHVERDVAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.26|      52|     714|     140|     230|       2
---------------------------------------------------------------------------
  172-  230 (83.15/110.93)	KEQLQWienintlLSIRLNLEDYDTLPYHFQNYTID...SGR...VTFKVPGEFEVDLTIADEDF
  888-  945 (83.11/40.21)	AAHLDW.......FNIHYTLPGLNRNPYALRRLTLQirlRGRresVEWELTREEPGPVKKPDDEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.91|      34|     687|      87|     120|      10
---------------------------------------------------------------------------
   87-  120 (56.71/46.94)	VKAAVIAKWSRNAQSVSKLIDLVWLLRQQHEKYQ
  746-  779 (55.20/45.45)	VGSTVLDTLAHRLQAIDKLADCVDAIRRSDRDIQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13976 with Med14 domain of Kingdom Fungi
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