<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13975

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGEYETNALVINNISSVNFAFYDPVSPTLASFGSNALELETALRRDGFLAYFDTVRRGVWCFRLLQKDRQQATPAFPKSVGSAGFAFSLTEEGFFESAALVKNRSLGQNAGNTPASSSSSSTSAGLDSAYRNTQSATLPSAQSFPAIGEQDSKTVSSVDSKVASSTPIKDVYEHFISAALSAVSSGFCANTGAIPLSSRILLLPRTSYNSCINVPGILASLRIYLTTTGSLVVSFTLSPAEGIINLSENLGHPLPSLSVTVLAAPLGMFATCHPLSISDTTATEGSFGQSPDTQVLRVRSERDNGSWRTICSKFLQARNIPSSFCESQSWIGLQRMRRKPTEQNVDGKRTPVIGAPSIFWPVNLCFCKMFSRLTIGDEGEDQSASQPDRNFDALKVAKQWFLGAGERDEILAKNKKERDAAVAREASLADNQAQHTSALSPLALQRSGNTNAPPGGLYPTPPDGVQNVVGATPSMDGTASSPGNNVTAAAAADVDSIRNVSSYGDNWENTDAKRDRIGSSFESENLFGELGPDMFGDTDITEADFNFFDEQPGDMGLASLDLPGLPNSDSNLDLAVGLPATHESQIKSDPPDIHLTDATSSPTFTKPELRHARSSLEEARRQTGLGANRSQFAGVKRPASPFNPDTVFKRIKASIDNHKTNQKNTRVNDSTHSSVFDKVDFGPSMSTVNSKYEGSGRFDYSLETSGETKSSFPNEPPTTDYLRRHVKGRKGLKELPAKVGQLFIRASGLQVPPSTGASPSNIPSNIEEAHSDADEISLVSDQDDSSYDSDEPLSPVKSLSVKRRLIDDDGESLATSFRELESVDASSPHLSLELPQTCKSEADLPLTKYFADPEPPLLQYSLPDEQFIMAAQILTDQFSTCTLLINTASQPLESRVNRRRQLTTLTRRSIQDIKSSLPPCLAIASEYQFRPFIELQDVPLLGQPTRMQPRPPGADQMRPSNLFQIPSPHFELRRYESKLSVLPSAVAFWESLGLSPSPGNKDINAICIFPDYEGLVDDMLVFTDRMRSIYESLKLGSFNRLPTTSGVDNGLFPFPVEKDPVPFNKSSPFLRPSLANCVTKVCQVLASMTTEEINFVVFFVYSPDVTGSIVECCAVFNQIFEGYKRLLSSKRLPVANDLALQLIPQDFVASSTSVAMPSPFEFSRLAMETYDRCTHFGGTAPSPAIILEQPPPRMIDFKLTTTPSASLLHENTCLHIAYAQSIDGRWITAAWTDNRGSQQMTASYCLGRKGKSLSRPLADVATEIWGATRDFISAWKVQWRIIIAKCGTMEQSEIELWSSLAQAESKASMSLTLIAVDTDPSMQLLPPVVRLSTNALSVFYTTPVSTPQGSMVSPEQSGNPPTPMRENVGTSAPTPGADNNPESDGDATLTELTDQTWGAVLSHRLNNSTSLMELNPALISGYLVKRGGSRIEDPPVVMEVSIVYNESNPRAYESLLREMLTYYRGLGTLARARGMVDKETDIRPWHIAAAEKAVKALYMLM
Length1503
PositionKinase
OrganismHypoxylon sp. CO27-5
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon.
Aromaticity0.08
Grand average of hydropathy-0.309
Instability index53.21
Isoelectric point5.19
Molecular weight163591.83
Publications
PubMed=28078400

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13975
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.36|      83|      89|     985|    1071|       1
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  985- 1071 (145.44/99.63)	PS.AVAFWESLGLSPSPGNKDINAICIF...PDYEG.LVDDMLVFtdrmRSIYESLK.LGSFNRLPTTSGVDNGLFPFPVEKDPVPFNKSSPF
 1074- 1162 (127.92/78.64)	PSlANCVTKVCQVLASMTTEEINFVVFFvysPDVTGsIVECCAVF....NQIFEGYKrLLSSKRLPVANDLALQLIPQDFVASSTSVAMPSPF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.94|      14|      15|     556|     570|       2
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  561-  576 (19.51/ 9.77)	SLDLPGLPNSdsNLDL
  833-  848 (21.44/ 6.18)	SLELPQTCKSeaDLPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.27|      15|      15|     409|     423|       3
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  409-  423 (23.76/19.08)	RDEILAKNKKERDAA
  426-  440 (24.52/19.98)	REASLADNQAQHTSA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     290.27|      92|     607|     263|     363|       5
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  263-  363 (144.84/94.66)	VLAAPL..GMFATCHPLSISDTTATEGSFGQSPDTQVLRVRSERDNGSWRTIC....SKFlQARniPssFCESQS..WIGlQRMRRKPTEQNVDGKR.TPVIGAPSifwP
  870-  970 (145.43/72.45)	IMAAQIltDQFSTCTLLINTASQPLESRVNRRRQLTTLTRRSIQDIKSSLPPClaiaSEY.QFR..P..FIELQDvpLLG.QPTRMQPRPPGADQMRpSNLFQIPS...P
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.74|      13|      15|     611|     623|       6
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  611-  623 (21.09/13.41)	LRHARSSLEEARR
  627-  639 (21.65/13.97)	LGANRSQFAGVKR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     132.52|      57|     278|     450|     513|       8
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  450-  476 (34.65/ 8.70)	...................................................................................................................................................................................................................................................................................................................................................................................................................................GNTNAPPGGLYPTPPDGVQNVVGATPS
  482-  513 (28.98/17.51)	SSPGNnVtAAAAADVDSIRNVSSYGDNWENTD..............................................................................................................................................................................................................................................................................................................................................................................................................................
  763-  792 (36.72/ 8.19)	NIPSN.I.EEAHSDADEISLVSDQDDSSYDSD..............................................................................................................................................................................................................................................................................................................................................................................................................................
 1180- 1206 (32.17/ 7.57)	................................eplspvkslsvkrrlidddgeslatsfrelesvdassphlslelpqtckseadlpltkyfadpeppllqyslpdeqfimaaqiltdqfstctllintasqplesrvnrrrqlttltrrsiqdiksslppclaiaseyqfrpfielqdvpllgqptrmqprppgadqmrpsnlfqipsphfelrryesklsvlpsavafweslglspspgnkdinaicifpdyeglvddmlvftdrmrsiyeslklgsfnrlpttsgvdnglfpfpvekdpvpfnksspflrpslancvtkvcqvlasmtteeinfvvffvyspdvtgsiveccavfnqifegykrllsskrlpvandlalqlipqdfvasstsvampspfefsrlametydrcthfgGTAPSPAIILEQPPPRMIDFKLTTTPS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13975 with Med13 domain of Kingdom Fungi
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