<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13971
Description |
Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MTFNPQTPQSPSQFSPSIGDQVSSMNSSMTSITTALPTPAHSVNGSAQAADISHDTTMTDAYSTKRKYPFDDTGDHEQKKVNLENRRVGIENLHLDVGEKYLLRHTPYPEFYPCLSDDLFEMFGLTGVAAEVARTKPNGEKNALRKTYKGQIKTLGLSGHFDAVKKDPEAPDGLQAMTLIPEDVWFTREVSGKEIDKGLSQVHQTQLSRAATMAKGPIPKNAWDISVLGDLAPGSIPRKTGHDQSTRPTAPSTPAASAPGVTPKPNKPLTPQVDRARRLGKKRSYQDSSFEGYGEGYADDDAGGYSTGDGDDRSKLKRRKQVHTDHPSSANLFTDR |
Length | 336 |
Position | Head |
Organism | Hypoxylon sp. CO27-5 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Xylariomycetidae> Xylariales> Hypoxylaceae> Hypoxylon.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.820 |
Instability index | 39.83 |
Isoelectric point | 7.17 |
Molecular weight | 36644.26 |
Publications | PubMed=28078400
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13971
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.23| 14| 16| 213| 226| 1
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213- 226 (28.05/16.04) MAKGPIP.KNAWDIS
231- 245 (22.18/11.24) LAPGSIPrKTGHDQS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 35.35| 10| 39| 98| 108| 2
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98- 108 (16.10/16.57) GEKYLLRHTpY
139- 148 (19.26/12.63) GEKNALRKT.Y
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