<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13969

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSEFESLRDVALRPWPVNRTDDLSKDAMLQQVEQLARERGHLRNITEQSLQADIDAGKDVPDDLKEISEEDEEEKEPLTLDERKAEIAKMQMEMASHLDWARFAASNALDLISMVLSADPNKRLPASFSHTFREAGLNQGLPFGSIGVARENHEYDELKAAERSRREEQERRQDLVAKAARMEALDTATDEILKAAKSLEKEVRRETKYWQEIVSISDKGWPIHRMGRNVRHAPFGVRFGASEANNHFKARGSAPLRMDKDGSIILDPNLALKPKTLRVRISENGEITGSAQLPAESLLDGLAVEKSIRLARDSLLEEELFHEMSLETQQLLPYGVRLQDSIITVDATVADSSASSRQILIDCIPRDSKGPDKQGYTHDWLAHHIGEALRLLLTHEHSMRLYRRTQLPPPLTSRKQEKKPPPLLRTLLAMMHHLQNADSLFAYLEGVSSTLESAGLEAPVETSREESWVKLRDSLAKSTRKDLTAADQLLEIFNKPFTGKASMTLPSSVGSQTEQLIIAIRTVIGAPTFGTEYKLTLPPSLATDLGLSIENNFQSTADVTSYLDWILALQLTHRVLKNEYAERAAVKDSEDGVAVTIKSDKKGTSANWDVSVELTEGKLVLQVTDTSSQVPSQRSQSWPGKGDNLPLKEQIKAWVE
Length656
PositionHead
OrganismEpicoccum nigrum (Soil fungus) (Epicoccum purpurascens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Epicoccum.
Aromaticity0.05
Grand average of hydropathy-0.518
Instability index50.36
Isoelectric point5.48
Molecular weight73363.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13969
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.02|      14|      14|     167|     180|       1
---------------------------------------------------------------------------
  167-  180 (21.86/12.20)	EEQERRQDLVAKAA
  183-  196 (19.16/ 9.89)	EALDTATDEILKAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.11|      22|     116|     420|     445|       3
---------------------------------------------------------------------------
  389-  412 (34.88/23.76)	LRLLLTHEHsmRLYRRTQLPPPLT
  424-  445 (38.23/19.70)	LRTLLAMMH..HLQNADSLFAYLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.66|      12|      31|     497|     508|       4
---------------------------------------------------------------------------
  497-  508 (21.80/12.55)	FTGKASMTLPSS
  529-  540 (22.86/13.47)	FGTEYKLTLPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.03|      43|     133|      65|     108|       5
---------------------------------------------------------------------------
   65-  108 (67.83/53.08)	KEISEEDEEEKEPLTLDERKAEIAKMQMEMaSHLDW.ARFAASNA
  201-  244 (73.19/52.63)	KEVRRETKYWQEIVSISDKGWPIHRMGRNV.RHAPFgVRFGASEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.70|      12|      31|     265|     278|       6
---------------------------------------------------------------------------
  265-  278 (10.93/14.86)	ILDpNLALKpKTLR
  298-  309 (19.77/10.38)	LLD.GLAVE.KSIR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13969 with Med17 domain of Kingdom Fungi
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