<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13956

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLRTCQTNAQVIGDFEAVAYQAFSVARSATQPAETLRDWSPDQDTSAVEAALRDRQLLIVRDATRPWLWLFTPAPAAVDKAGASPSPSPSPPDLPDLTGYTFQREQHGFTKALEFARPPISARNPTAATHPALMAAQHRASASRSNLTSAQPTTAEQPPSLDCFAVYDLFTSAVVALITLSLVKACGVVSLNYRTFVSSPMQTQTQTNHSEFASFPTPHWLSSVDVHWTSAGTLIVSTFTDKVNDIGSLDNTMSAVELKQLVGTVVRVAPNGMLGRVMSFDDPLQLAQDDTAQRPRRKRTRRSNLEQSIDKWKNAVKRWLTWKGYSLSDLDHTNAWVRLRTTFDSQPATPTTFAVPSEQDVLWPRALCYYHRASSEAVLPVSAETPLNTSDSVLRWFESVDSTGYRDPCDVAQEWFAAKAERDKSADTQRKAKKAEEDAFRRKEENHGLFPSSPLNTRMGTYGELQPVSGVYPTPPDGVAPGAPIFASDTPSVTGATSNVILASGGTNPAINLSAPQDSVSAEPPQQASTSPAFATDHEPISTSNNNDDLFGDDMDEGGYEENAVGEDDFDFFDGPNDGDVDMTDAPPRADTKVEAAQPPEKGAQTDTSLKAEEQEESADPLAALEEALSSSVNQPLNSPQTTEKKELAHAADGSTAKPHAAPIDQAGLQEREQKPPSTKAPTPPLSPSKVRETLKPSPKTALTIHIPPAQSQDRRGSSFGPLAFSRKMSVSDAKYQDGRYGIHTDVKAKEAHTATPASARPKSLRDVPLLTKFRYAAAVASATKLPKITPSIQGLNDDSEDESDTENESSVVSDEDAEDVQPTMQAPFSGGPITLAKRKLPTDGNATPLSVTSFAESFGGDLLELQTLHFDDNSLLNFEPSSWDWSLVKLAPPTVKLGAGVRYSMPLFPHPVGQVPDTPTSQPDLSFEIQDEKHWSGSDSINIAQMVTEQVISATLDILNEEIVSEDAIRRSSEMRWATVIKTVFPKAIDCALPALAAVNDVFPEMPAHAKSQQRIQARKPNETPAVPGSQIYPINPPFIRVRRGDSPWDLLPPAVTFWETLGLAPVNGSKNVVAFCIYPHSDSLRPGLEGFLLHMQLAYDSCKLGTHTRVNTVSEYESGLVPCRIATPAAPRAVYKALRETCVKLGKMLAARHANIQEQHESRVDAFIIYMVNPFEESSALWELCAAFWTLFQTYGQGPTHPSQPQKPDLVLQIVPIRYIASFDHPVILSSSIYSRLAREVYNRSPPNAEPEDKTPLPIASAPAFQLEESSPRNVPFKLQSEPPQDLLRENSYMHLAYAISLDGTWLTVAWTDSCGKSQATSTYHLGTRPFSELAKEIWVTTIGILQARKVHWRVCIARAGVMDRDELEAWVYLITCPTSLNLFITLLTVDPKPLYKFTPAAAIPTTAQSNPNTPTATPGAGVSPDPTIGLTPAATPSAADPPLDPTQDPDSRLVDSTDETWGVILAHRLHNTNATSVFSPALISGLLIKRGPGGPGEAPLSAPDNAPGPLAVGVNILWIGAVGSTRAATSPFPPTPGGSEPPAHPAAGSYLNAGSSGGGGQGPSSGASSAAAGNPPAQQQTSSLMWTPTPQTRATAENLLKEILQQFRGLGLLARLRGTRGSRYGSVPWHVAACLRGVEGMERVVGGR
Length1653
PositionKinase
OrganismEpicoccum nigrum (Soil fungus) (Epicoccum purpurascens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Epicoccum.
Aromaticity0.07
Grand average of hydropathy-0.379
Instability index51.28
Isoelectric point5.29
Molecular weight178490.74
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     249.67|      58|     403|      84|     148|       1
---------------------------------------------------------------------------
   84-  142 (102.81/45.06)	GASPSP....SPS...PP....DLPDLTGYTFQ..REQHGFTKALEFARP..PISARNP.TAATHPALmAAQHRA
  472-  542 (76.61/28.14)	GVYPTPpdgvAPG...APifasDTPSVTGATSNviLASGGTNPAINLSAPqdSVSAEPPqQASTSPAF.ATDHEP
 1538- 1586 (70.25/26.93)	...P.P....TPGgsePP....AHPAAGSYLNA..GSSGGGGQG........PSSGASS.AAAGNP...PAQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     673.99|     204|     403|     841|    1055|       2
---------------------------------------------------------------------------
  183-  311 (153.53/69.48)	....................................................SLVK.ACGVVSLNYRTFVSSPM......QT.QTQTNHSE..FaS.F...PTPHWLSSVDVHWTS..AGT.LIVSTFTDKVN..DIGSLDNTMSAVELKQlvGTVVR.VAPNGM........LGRVMSFDDPLQlAQDDTAQRPRRKRTRRSNLEQSI..........................
  316-  453 (136.65/59.09)	NAVKRWLTWKGYSL.SDLdhtnawVRLRTT.FDSQpaTPTTFAvPSEQDvlW.......PRA.LCYYHRASSEAV.LPVS..AETPLNTSDsvL.RwFESVDSTGY..RDPCDVAQewFAAKAERDKSADTQRKaKKAEEDAFRRKEEN........HGLFP.........................................................................
  848- 1055 (337.63/187.32)	NATPLSVTSFAESFgGDL......LELQTLhFDDN..SLLNFE.PSSWD..WSLVKlAPPTVKLGAGVRYSMPLFpHPVGQVPDTPTSQPD..L.S.FEIQDEKHWSGSDSINIAQ..MVTEQVISATLDILNE.EIVSEDAIRRSSEMRW..ATVIKTVFPKAI.....DCALPALAAVNDVFP.EMPAHAKSQQRIQARKPNETPAVPGSQIYPINPPFIR.VRRGDSPWDLL
 1393- 1469 (46.17/13.50)	..............................................................................................................................................................TVDPKPLykftpAAAIPTTAQSNPNTPtATPGAGVSPDPTIGLTPAATPSAADPPLDPTQDPDSRlVDSTDETWGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.51|      46|      84|     594|     639|       3
---------------------------------------------------------------------------
  594-  632 (52.80/26.27)	................................................TKVEAA...QPPEKGAQTDTSLK.............AEEQEESADPLAALEEALS
  633-  730 (37.88/16.52)	SSVNQPLnspqttekkelahaadgstakphaapidqaglqereqkppsTK..AP...TPPLSPSKVRETLKpspktaltihippAQSQDRRGSSFGPLAFSRK
  731-  768 (48.31/23.34)	MSVSD.................................................akyQDGRYGIHTD..VK.............AKE.AHTATPASARPKSLR
  769-  812 (22.52/ 6.49)	...DVPL............................ltkfryaaavasaTKLPKI...TPSIQGLNDDSEDE.............SDTENES............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.00|      10|    1055|      74|      83|       7
---------------------------------------------------------------------------
   74-   83 (19.79/10.15)	TP.APAAVDKA
 1131- 1141 (16.21/ 6.71)	TPaAPRAVYKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13956 with Med13 domain of Kingdom Fungi
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