<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13956

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLRTCQTNAQVIGDFEAVAYQAFSVARSATQPAETLRDWSPDQDTSAVEAALRDRQLLIVRDATRPWLWLFTPAPAAVDKAGASPSPSPSPPDLPDLTGYTFQREQHGFTKALEFARPPISARNPTAATHPALMAAQHRASASRSNLTSAQPTTAEQPPSLDCFAVYDLFTSAVVALITLSLVKACGVVSLNYRTFVSSPMQTQTQTNHSEFASFPTPHWLSSVDVHWTSAGTLIVSTFTDKVNDIGSLDNTMSAVELKQLVGTVVRVAPNGMLGRVMSFDDPLQLAQDDTAQRPRRKRTRRSNLEQSIDKWKNAVKRWLTWKGYSLSDLDHTNAWVRLRTTFDSQPATPTTFAVPSEQDVLWPRALCYYHRASSEAVLPVSAETPLNTSDSVLRWFESVDSTGYRDPCDVAQEWFAAKAERDKSADTQRKAKKAEEDAFRRKEENHGLFPSSPLNTRMGTYGELQPVSGVYPTPPDGVAPGAPIFASDTPSVTGATSNVILASGGTNPAINLSAPQDSVSAEPPQQASTSPAFATDHEPISTSNNNDDLFGDDMDEGGYEENAVGEDDFDFFDGPNDGDVDMTDAPPRADTKVEAAQPPEKGAQTDTSLKAEEQEESADPLAALEEALSSSVNQPLNSPQTTEKKELAHAADGSTAKPHAAPIDQAGLQEREQKPPSTKAPTPPLSPSKVRETLKPSPKTALTIHIPPAQSQDRRGSSFGPLAFSRKMSVSDAKYQDGRYGIHTDVKAKEAHTATPASARPKSLRDVPLLTKFRYAAAVASATKLPKITPSIQGLNDDSEDESDTENESSVVSDEDAEDVQPTMQAPFSGGPITLAKRKLPTDGNATPLSVTSFAESFGGDLLELQTLHFDDNSLLNFEPSSWDWSLVKLAPPTVKLGAGVRYSMPLFPHPVGQVPDTPTSQPDLSFEIQDEKHWSGSDSINIAQMVTEQVISATLDILNEEIVSEDAIRRSSEMRWATVIKTVFPKAIDCALPALAAVNDVFPEMPAHAKSQQRIQARKPNETPAVPGSQIYPINPPFIRVRRGDSPWDLLPPAVTFWETLGLAPVNGSKNVVAFCIYPHSDSLRPGLEGFLLHMQLAYDSCKLGTHTRVNTVSEYESGLVPCRIATPAAPRAVYKALRETCVKLGKMLAARHANIQEQHESRVDAFIIYMVNPFEESSALWELCAAFWTLFQTYGQGPTHPSQPQKPDLVLQIVPIRYIASFDHPVILSSSIYSRLAREVYNRSPPNAEPEDKTPLPIASAPAFQLEESSPRNVPFKLQSEPPQDLLRENSYMHLAYAISLDGTWLTVAWTDSCGKSQATSTYHLGTRPFSELAKEIWVTTIGILQARKVHWRVCIARAGVMDRDELEAWVYLITCPTSLNLFITLLTVDPKPLYKFTPAAAIPTTAQSNPNTPTATPGAGVSPDPTIGLTPAATPSAADPPLDPTQDPDSRLVDSTDETWGVILAHRLHNTNATSVFSPALISGLLIKRGPGGPGEAPLSAPDNAPGPLAVGVNILWIGAVGSTRAATSPFPPTPGGSEPPAHPAAGSYLNAGSSGGGGQGPSSGASSAAAGNPPAQQQTSSLMWTPTPQTRATAENLLKEILQQFRGLGLLARLRGTRGSRYGSVPWHVAACLRGVEGMERVVGGR
Length1653
PositionKinase
OrganismEpicoccum nigrum (Soil fungus) (Epicoccum purpurascens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Epicoccum.
Aromaticity0.07
Grand average of hydropathy-0.379
Instability index51.28
Isoelectric point5.29
Molecular weight178490.74
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     249.67|      58|     403|      84|     148|       1
---------------------------------------------------------------------------
   84-  142 (102.81/45.06)	GASPSP....SPS...PP....DLPDLTGYTFQ..REQHGFTKALEFARP..PISARNP.TAATHPALmAAQHRA
  472-  542 (76.61/28.14)	GVYPTPpdgvAPG...APifasDTPSVTGATSNviLASGGTNPAINLSAPqdSVSAEPPqQASTSPAF.ATDHEP
 1538- 1586 (70.25/26.93)	...P.P....TPGgsePP....AHPAAGSYLNA..GSSGGGGQG........PSSGASS.AAAGNP...PAQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     673.99|     204|     403|     841|    1055|       2
---------------------------------------------------------------------------
  183-  311 (153.53/69.48)	....................................................SLVK.ACGVVSLNYRTFVSSPM......QT.QTQTNHSE..FaS.F...PTPHWLSSVDVHWTS..AGT.LIVSTFTDKVN..DIGSLDNTMSAVELKQlvGTVVR.VAPNGM........LGRVMSFDDPLQlAQDDTAQRPRRKRTRRSNLEQSI..........................
  316-  453 (136.65/59.09)	NAVKRWLTWKGYSL.SDLdhtnawVRLRTT.FDSQpaTPTTFAvPSEQDvlW.......PRA.LCYYHRASSEAV.LPVS..AETPLNTSDsvL.RwFESVDSTGY..RDPCDVAQewFAAKAERDKSADTQRKaKKAEEDAFRRKEEN........HGLFP.........................................................................
  848- 1055 (337.63/187.32)	NATPLSVTSFAESFgGDL......LELQTLhFDDN..SLLNFE.PSSWD..WSLVKlAPPTVKLGAGVRYSMPLFpHPVGQVPDTPTSQPD..L.S.FEIQDEKHWSGSDSINIAQ..MVTEQVISATLDILNE.EIVSEDAIRRSSEMRW..ATVIKTVFPKAI.....DCALPALAAVNDVFP.EMPAHAKSQQRIQARKPNETPAVPGSQIYPINPPFIR.VRRGDSPWDLL
 1393- 1469 (46.17/13.50)	..............................................................................................................................................................TVDPKPLykftpAAAIPTTAQSNPNTPtATPGAGVSPDPTIGLTPAATPSAADPPLDPTQDPDSRlVDSTDETWGVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.51|      46|      84|     594|     639|       3
---------------------------------------------------------------------------
  594-  632 (52.80/26.27)	................................................TKVEAA...QPPEKGAQTDTSLK.............AEEQEESADPLAALEEALS
  633-  730 (37.88/16.52)	SSVNQPLnspqttekkelahaadgstakphaapidqaglqereqkppsTK..AP...TPPLSPSKVRETLKpspktaltihippAQSQDRRGSSFGPLAFSRK
  731-  768 (48.31/23.34)	MSVSD.................................................akyQDGRYGIHTD..VK.............AKE.AHTATPASARPKSLR
  769-  812 (22.52/ 6.49)	...DVPL............................ltkfryaaavasaTKLPKI...TPSIQGLNDDSEDE.............SDTENES............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.00|      10|    1055|      74|      83|       7
---------------------------------------------------------------------------
   74-   83 (19.79/10.15)	TP.APAAVDKA
 1131- 1141 (16.21/ 6.71)	TPaAPRAVYKA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13956 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AERDKSADTQRKAKKAEEDAFRRKEENHGLFPSSPLNTRMGTYGELQPVSGVYPTPPDGVAPGAPIFASDTPSVTGATSNVILASGGTNPAINLSAPQDSVSAEPPQQASTSPAFATDHEPISTSNNNDDLFGDDMDEGGYEENAVGEDDFDFFDGPNDGDVDMTDAPPRADTKVEAAQPPEKGAQTDTSLKAEEQEESADPLAALEEALSSSVNQPLNSPQTTEKKELAHAADGSTAKPHAAPIDQAGLQEREQKPPSTKAPTPPLSPSKVRETLKPSPKTALTIHIPPAQSQDRRGSSFGPLAFSRKM
2) AKYQDGRYGIHTDVKAKEAHTATPASARPKSLR
3) IPTTAQSNPNTPTATPGAGVSPDPTIGLTPAATPSAADPPLDPTQDPDSRLVDST
4) PKITPSIQGLNDDSEDESDTENESSVVSDEDAEDVQPTMQAPFSGGPITLAKRKLPT
5) TRAATSPFPPTPGGSEPPAHPAAGSYLNAGSSGGGGQGPSSGASSAAAGNPPAQQQTSSLMWTPTPQTRATAENLL
422
736
1408
789
1530
731
768
1462
845
1605










Molecular Recognition Features






MoRF SequenceStartStop




1) GGYEENAVGEDDFDFFD
2) KSLRDVPLLTKFRYAAA
3) KTALTIH
4) YGIHT
560
765
702
743
576
781
708
747