<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13953

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGIIMMNHSANESVRDGENKKRSFDGKFVNGDSQKGTAVMSETVRNGASNGTSDAVSAPTMSDSPPEIDKIGPEAYHPLSKLLARMAQECYNGLEETLHKMSGMSLGQQANGALSNGVVPQDNPEVNKRKKLLLLKFAQDNRAKFIKLLVLTEWGQKSAVDISKVIDLYAWAKEQAAYMDFADEQINQIKILSAYARENNPDIRTALEVLSTGRAPWIPTLDYIPPDTISSDKALKLLRAMNTSLSIRLNVHETLPRHLRNWRIQSGRATFVINDEMEFDVVSFVEDTSDQWWFLDLRLLFASAPVIKTGSRFWEQLQPQADYVLQEKGLAGLFDFLHNFVLTHKLSILRSQAIELVRTGWAGSVKVEKVHREVVVQYWTDRSGKKNWVEFGTTSNKPKNGKTSWRGPPIPSLKARWFCQGKEMTDANLGIDWKDISMERILKRVIALHTTQILQSTRGHFDPRLAVQVDMSNTEPTHCSLTATLGALSNSVTLSLETVTGSFIMQPACALSARAEYAMNQGREPAQIAGILTSMLLQTLRDQTQRIAQQLGWQRITRQAFRPDSVKAAVKSDVLEYSLYSPRGWTSDWALAAVVSTTGESWWIFELGSGGMSIRYAEQIVMERPDGSSLAINRDTLSRIARVAVQLLSFRVTARQLAAENKTFTLRRECSASGKPGGTAKVIQGWALYVQTADLLATKPGQQPWLEDTIAITCEGLKINSRSVWHIASGRLVQSEIADMQKLMAAAPQNNFKFTADGSFRILLATPFGSDVLGELRARLRDVNRLRSFAVTLQKRRMRLTSSSLQKVQFRYGPSPHAAAVSFASENEIALEIPPLNPHFRIRHLLATIANDRNPSLASLPKGDTNGLDALCITLLNTRSLLTVLAELDSATPGNVRNPAIHVHSVFKYRITYENPLCTFDIGLRNKSDKVYWFIEDNINHPPDIRAAPERNPRHRRLDNLQEKLKDLYKSKADNWCGTRKGIIAELDAVPDALRKLHDAVLSCKMEGGYKPPPPLEVVQPQQQQQPTGMPSQVQRRQSQQQQQQQQQQQRPQQFSPQMQRKQPSVQQQPNGRPQQNGQRSTPQQMTPQQIQHMQQMQQARAAQQQQARQGKSDIIEID
Length1120
PositionTail
OrganismEpicoccum nigrum (Soil fungus) (Epicoccum purpurascens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Epicoccum.
Aromaticity0.07
Grand average of hydropathy-0.465
Instability index46.22
Isoelectric point9.46
Molecular weight125661.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13953
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.58|      19|      19|    1023|    1041|       1
---------------------------------------------------------------------------
 1026- 1050 (31.27/15.05)	QQPTGMPSQVQRRQSQqqqqqqQQ.Q
 1051- 1068 (26.62/11.64)	QRPQQFSPQMQRKQPS........vQ
 1069- 1086 (29.69/13.89)	QQPNGRPQQNGQRSTP......QQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.12|      20|      46|     849|     894|       2
---------------------------------------------------------------------------
  783-  802 (34.09/22.75)	DVNRLRSFAVTLQKRRMRLT
  865-  884 (34.02/22.47)	DTNGLDALCITLLNTRSLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     221.65|      49|      50|     263|     311|       3
---------------------------------------------------------------------------
  214-  248 (38.86/19.35)	.....GRAPWIPTlDYIPPDTIS.....SDKALKL.LRAMNTSL.SI....
  263-  311 (83.06/49.44)	WRIQSGRATFVIN.DEMEFDVVSFVEDTSDQWWFLDLRLLFASA.PVIKTG
  315-  361 (63.42/36.07)	WEQLQPQADYVLQ.EKGLAGLFDFLHNFV...LTHKLSILRSQAiELVRTG
  380-  406 (36.32/17.62)	WTDRSGKKNWV......EFGTTSNKPKNGKTSW..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.45|      11|      46|     848|     858|       4
---------------------------------------------------------------------------
  848-  858 (20.20/12.73)	ATIANDRNPSL
  892-  902 (21.26/13.81)	ATPGNVRNPAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.55|      31|      55|      41|      71|       7
---------------------------------------------------------------------------
   41-   71 (54.30/32.26)	MSETVR..NGASNG..TSDAVSAPTMSDSPPEIDK
   95-  129 (44.25/24.96)	LEETLHkmSGMSLGqqANGALSNGVVPQDNPEVNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.90|      20|      48|     575|     595|       8
---------------------------------------------------------------------------
  552-  571 (34.61/16.74)	LGWQRITRQAFRPDSVKAAV
  576-  595 (36.29/17.50)	LEYSLYSPRGWTSDWALAAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13953 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGIIMMNHSANESVRDGENKKRSFDGKFVNGDSQKGTAVMSETVRNGASNGTSDAVSAPTMSDSPPEIDKIG
2) VLSCKMEGGYKPPPPLEVVQPQQQQQPTGMPSQVQRRQSQQQQQQQQQQQRPQQFSPQMQRKQPSVQQQPNGRPQQNGQRSTPQQMTPQQIQHMQQMQQARAAQQQQARQGKSDIIEID
1
1002
73
1120










Molecular Recognition Features






MoRF SequenceStartStop




NANANA