<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13952

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDPSFTNMDDLFGDSEHVDLQSIAVPPVKGLARRVDELGASGCCQKIAWSKNGCVAYITPDGAAVHLKVFSRDIETGAWDLGKDVPLDIPQGREHFPFVHLSWSHLGNDMVVVDVAGRVLNFSCAMALDRMQYFKAELAHPEAEADGVVGLHWLAIYPYEQKNQIAWSAERDGAKWKWNIRSHLFHDAHHPIPTKASLIYLKRHGELVLRFQQNDNAWQESSTLLGPMISTQESFTHAAFASNNDDSLLMAAYDVKRQMHLYRIETAWQVAQEKHSQNAGHFDKPILQVSLIALEENCGPANMITTDIGSGTEARGPAPAQLTHLSFLPVTPDQSDGSLPTIQAIYCKPPNLVAVDHLQSQEAPHSVIVKWEVHQLQQNQLHPSLDQVTSKKKAIGSVTARTIFQLKRTTDFPMHAVVLTCVSVWYHMLLAFHYSDGTIEFRKRSTMEILVGDGNTDNVTSLFQTGFAFPHGEPSIHMALSPNYCIAACMQQDSTTKLRSLEYQRGTLSISDNAPENEPRNSAALAALILQSASSANQYFSSDDIFSVMGSLAPHRTREFTTLLFEALQLNIDCGVDDSNTNYLMLLGRSPFFVKVLSSMHLLGLSSPVDRDLSSKMAWIILNIKYVTQILTSITRMHGHLDKILLRPEVVPQFIGICRWIMHFIAYTMDGLFELGRALDTSTTPLDAASLTKFFREQNNPAVLLLLSAFPRTMFKLWAQPLAWIKRSADNFTSASAPVQAPEIRKLYVPLAAALADIPFDWRWFERLVSETHDATRSLYKKANLSDAARNSLERDTLLGTVPDLFAPLAARLITDTLWNSDAPGGALADKLDSGRLMFFDTTWLGFTESQRARHWHNDHVVDVCQKMVIRGVGAQEHPITAATLAARKRSDSQLSANGRRAEGESESESERKRLLRRCVRCASLMEDVTVNQAGYTPHHLSWLMGIAKHCVCGNSWMLVPEGKGDK
Length967
PositionTail
OrganismEpicoccum nigrum (Soil fungus) (Epicoccum purpurascens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Epicoccum.
Aromaticity0.08
Grand average of hydropathy-0.187
Instability index43.35
Isoelectric point6.27
Molecular weight107841.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13952
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.92|      17|      48|     298|     314|       1
---------------------------------------------------------------------------
  298-  314 (31.62/20.38)	CGPANMITTDIGSGTEA
  347-  363 (31.30/20.10)	CKPPNLVAVDHLQSQEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.76|      36|      49|     130|     167|       2
---------------------------------------------------------------------------
  130-  167 (58.22/45.89)	RMQYFKaELAHPEAEADGVVGL..HWLAIYPYeQKNQIAW
  181-  218 (61.55/39.35)	RSHLFH.DAHHPIPTKASLIYLkrHGELVLRF.QQNDNAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.63|      27|     102|     560|     620|       3
---------------------------------------------------------------------------
  451-  478 (46.74/17.07)	VGDGNTDNVTSLFQTGFaFPHGEPSIHM
  576-  602 (47.89/66.51)	VDDSNTNYLMLLGRSPF.FVKVLSSMHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.40|      33|     102|     659|     691|       4
---------------------------------------------------------------------------
  659-  691 (57.95/38.94)	RWIMHFIAYTMD...GLFELGRALDTSTTPLDAASL
  763-  798 (48.45/31.33)	RWFERLVSETHDatrSLYKKANLSDAARNSLERDTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.27|      12|      55|     744|     755|       8
---------------------------------------------------------------------------
  744-  755 (20.63/13.57)	IRKLYVPLAAAL
  802-  813 (21.64/14.61)	VPDLFAPLAARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.00|      18|     838|      81|     103|       9
---------------------------------------------------------------------------
   81-  102 (22.91/21.22)	LGKDVPLDiPQGreHFPFvHLS
  925-  942 (34.09/12.79)	LMEDVTVN.QAG..YTPH.HLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13952 with Med16 domain of Kingdom Fungi
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