Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSDHGAKRQRLDNSGRYSPASPPFDVAAKASGHTTKPIQPRTPTSPPCSSMNPHLDGRSAVTATAPAASPARTPPASATMVASASQPATSVSAQHPFPTPASTTGHSYSTNIDSDGDALMDDGPDEPARGLGIHTHSNHDRRGQSLFSEKGGLKAAEGISGSMLFLSDADTYQQSRPHGSQNLFRLYHLERLAKSVARVDPVTGEKINKLRKSYEGHIKTLQIAGKPKAVKMDDIFSAPMSVPDEHWDATNSGKEPWRKLGADKTSLQPELGSLLDSAFGGMGPGALPPSDASKYKAYIGTDDNLRPKAATEAQVRTPVPSSAPTPNAHALPRRPERSGSKRQYNEDSYQGYSEGYGDDFATDSTGEDGSRGGFKRRKTQFERTVHSVEVGGVRR |
Length | 395 |
Position | Head |
Organism | Epicoccum nigrum (Soil fungus) (Epicoccum purpurascens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Didymellaceae> Epicoccum. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.829 |
Instability index | 50.34 |
Isoelectric point | 9.07 |
Molecular weight | 42184.05 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13950 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 58.69| 12| 20| 63| 74| 1 --------------------------------------------------------------------------- 30- 43 (18.07/ 6.50) ASGHTTK.PiqPRTP 63- 74 (22.74/10.22) ATAPAAS.P..ARTP 84- 96 (17.88/ 6.36) ASQPATSvS..AQHP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.22| 16| 25| 116| 131| 2 --------------------------------------------------------------------------- 116- 131 (29.63/15.25) GDALMDD.GPDEPARGL 143- 159 (22.59/10.10) GQSLFSEkGGLKAAEGI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FKRRKTQF 2) SKYKAYIGTD | 374 293 | 381 302 |
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