<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13943

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEEEPAWKKLKLSLERPYKDDNGEPIPELLDITPDGQHIYRPREDPTTAVGTKLRRIFLERGIDFFEAQSSSRAYPPPKIRDASTEDEGATDGEKHAESSNAMTPEELYKMRVSVLPQLYIAFGEMCQARDLLALLLSTSLPTQPSTLPPAPLAAAIVDKPPPILSVRAFDAQLTIGGKDKSLRAAADLFKGAAEKMEESRLAGERYWLDALKIRRGNWGLIPAPLPLGSATGKGADKTSKDFLISFGLEESPSAFRRRAIGRMAPMDSVDTEHPLEFPLRQRTRLRVSLTRLLPDGTKHMCHSRLTDLDDGSLDGALRAAQVEVVEQEIFSALIKEASSLPTASAEVSERLIVLDAAQNTELRFELVGSDSVALQRSEDTEPLCDVIYLSLHVLLLRAHSALKVQRLNKTSISRTMAAAAPATPPPPLLQPVIDMLQYQEFWGRVRDEIDRVVAGLRAAGVSAKVHYDPVADSGEALVAALQSEKTSPVGGEVLLRIDDRHTLRFTTSSPSTLTAHLPQATLSIASISQLTQLLGDEISSRLLRRICEIGAERCEKVNGTWFVDLLSGRSVGRWEGCVLDFRISFNGALIGCSASRVNRDGRASQIETYRPGGQLTLFEWICHTIDSSLGR
Length632
PositionHead
OrganismTrametes coccinea BRFM310
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.06
Grand average of hydropathy-0.247
Instability index47.33
Isoelectric point5.74
Molecular weight69424.33
Publications
PubMed=26692083

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13943
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.02|      36|     222|     270|     309|       2
---------------------------------------------------------------------------
  270-  309 (60.49/47.48)	VDTEHPLEFPlrqrTRLRVSLTRLLPDGTKHM.CHSRLTDL
  498-  534 (57.53/35.76)	IDDRHTLRFT....TSSPSTLTAHLPQATLSIaSISQLTQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.49|      66|     347|     178|     263|       3
---------------------------------------------------------------------------
  178-  263 (95.77/95.03)	GKDKSLRAAADLFKGAAEKMEesRLAGeRYWLDALKIRR.GNWglipaplplgsatgkgaDKTSKDFLISF.GLEESPSAFRRRAIGR
  536-  603 (111.71/67.39)	GDEISSRLLRRICEIGAERCE..KVNG.TWFVDLLSGRSvGRW.................EGCVLDFRISFnGALIGCSASRVNRDGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.75|      51|     347|      19|      78|       4
---------------------------------------------------------------------------
   19-   78 (75.01/70.86)	KDDNGEPipeLLDITPDGQHIYRPREDPTTAVgTKLRRIFLERGIdffeaQSSSRAYPPP
  377-  427 (85.73/54.35)	RSEDTEP...LCDVIYLSLHVLLLRAHSALKV.QRLNKTSISRTM.....AAAAPATPPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13943 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYPPPKIRDASTEDEGATDGEKHAESSNAMT
2) KLKLSLERPYKDDNGEPIPELLDITPDGQHIYRPREDP
74
9
104
46










Molecular Recognition Features






MoRF SequenceStartStop




1) EPIPELLDI
2) MEEEPAWKKLKLSLERPYKDDN
3) QHIYRPRE
4) TKLRRIFLERGIDFFE
24
1
37
52
32
22
44
67