<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13938

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEQAVNGLVANGATPHPHTALPNGDALMHEPTPEDLEKELPVVMDGQVPLGELISRLSQTMYAELTEMAETMPHMSDAARKRYVADWVVKIKRQVVKLYAIAKWSRDASVVQKAMNITAFLMDQNRQFEEAIMGLKYGKESLDPARLRNHDLLTSLDVLTTGTYRRLPACIKELIIPPTPLNDEEVAKTLADIEDAMRYRLRTSEIVPWEMSQYRIADGRVVFTAPKLFEASLCLRGAGKNDGWFFVNVEFLFRVGGDQTGMQEFPRSPTGVLKRNITDEADARLAFYLPPDEPPPPEAEPPPRPQLPEGVVDAPLVRVFNFLQMMSLSYQLEILWYQAERMRSLGWADFLTVEMTNHRQKMVISYWVHKPPSIRPGQPAPSQAQARNRIPQLGGKLSISIVQVKEKTGRKAMRSPKARVLAELQERSKLDHSRPSDEVEHLRFEVEWEPEKGALGVTMGPEDVQIPPEELRIDPDDLDFESLLRKVIRRHTEGIMKFFQLQLMHGSITRNVFGAPGEVTFVGNGGAPSLRVHLCADEVVIVTVDPRTGRLMLRDTGDLAAAGRGPRFAAISDRLNETPWRLPEALLRLRLTTITDLAEQKVQYLGLQSFRERNFAPEELAKLGPDARGKLYIQLANFPNHYLVLVITDNDYRYALINVKVQRETMYNNMIMEDIGWLNVRRIHGDEYTIEPGVGPEPMVGQKRKREDGLEAAPAEQYSSSFRLETKVLRELYAYCCARVAYTKVEQQFKLRGIPYTHVYSTANAAAPELAHIQSSLARSIPALCVLSSDILSGAPAAEAAMPNIRVIPLNWWSSDQAKVVTCVKLKYVQQPIGKRASGTTVIRPSKRIIYDTREAIVSFLSDDVDKCVDEFLEEWARVSKMVVIAREVAQMSTKYLWTDVRLLSFDLQTVEFAYAADYTLSLTCTDQLSSSGGSYHLRFGRVQPEDEHRMDVDGDHSAGPAHNPHEDVEPYMRNLLRHGRLSSALHRLVGLLRETLPVVAELEDIRVAAARSGTCVDTFAKSAGWFRILYGDLRHALDFRLMAGARVVILDGSHSLFDDNADDTPLRRLMGPTAKATSSLPRAESAALQPIPDFPALVQEAIKAAVAHGVSGQFAPIDIGVICDVAAVRVVGRMLHGKVFEKLESRANSKS
Length1152
PositionTail
OrganismTrametes coccinea BRFM310
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.07
Grand average of hydropathy-0.263
Instability index43.81
Isoelectric point6.30
Molecular weight129079.56
Publications
PubMed=26692083

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP13938
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     404.28|     132|     148|     331|     476|       1
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  331-  410 (72.73/73.79)	.........................................................................................................QLEILWYQAERMRSLGWADFLTVEMTnHRQKMVISYWVHKPPSIrpGQ.......PAPSQaqarnRIpQLGGKlSISIVQVKEKTGR
  411-  550 (197.46/145.66)	KAMRSPKarvLAELQERSKLDHSRPSDEVEHLRFE..VEWEPEK.GALGVtMGPEDVQIPPEEL.RIDPD.................................dlDFESLLRKVIRRHTEGIMKFFQLQLM.HGS...ITRNVFGAP....GEvtfvgngGAPSL.....RV.HLCAD.EVVIVTVDPRTGR
  561-  702 (134.10/86.07)	AAGRGPR...FAAISDRLNETPWRLPEALLRLRLTtiTDLAEQKvQYLGL.QSFRERNFAPEELaKLGPDargklyiqlanfpnhylvlvitdndyryalinvkvQRETM.YNNMIMEDIGW...LNVRRI.HGDEYTIEPGVGPEPMV..GQ.......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.21|      51|     779|      12|     103|       2
---------------------------------------------------------------------------
   27-   78 (85.49/109.10)	LMHEPTP...EDLEKELPVVMDG...QVPLGELIS.RLSQTMYAElTEMAETMPHMSDA
  174-  231 (70.72/24.68)	LIIPPTPlndEEVAKTLADIEDAmryRLRTSEIVPwEMSQYRIAD.GRVVFTAPKLFEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.21|      12|     779|     234|     245|       3
---------------------------------------------------------------------------
  234-  245 (25.57/17.12)	CLRGAGKNDGWF
 1016- 1027 (24.64/16.24)	CVDTFAKSAGWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.70|      25|     495|     138|     165|       7
---------------------------------------------------------------------------
  138-  165 (38.88/33.84)	GKESLDPARLRNHDLLTsldVLTTGTYR
  629-  653 (45.82/30.96)	GKLYIQLANFPNHYLVL...VITDNDYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.61|      58|      96|     954|    1014|       9
---------------------------------------------------------------------------
  954- 1014 (94.56/73.41)	DGDHSagpAHNPHEDVEPYMRNLLRHGRLSSALHRLVGLLRETLPVVAEL..EDIRVAAAR..SG
 1052- 1113 (90.05/60.99)	DGSHS...LFDDNADDTPLRRLMGPTAKATSSLPRAESAALQPIPDFPALvqEAIKAAVAHgvSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13938 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVNGLVANGATPHPHTALPNGDALMHEPTPEDLEKELP
4
41










Molecular Recognition Features






MoRF SequenceStartStop




1) LAFYL
285
289