<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13937

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRPTYYMPLRTLLPLPAGTPIILLPHGVPAYFLTTYRGPSTALTAQFEDALCGYGVGNWKACGSSRSSEHASSQFQRGPSGQSAPSYLIAWLAVQNKQGEDKGMPVVWPATLCISYHTSSPSAHARSPLSYIPELPPQLQASPPPPASAIPAMLSFTTAASSAADIPASAATPQSIAPSLTAERDRLTPSFQRRSSLLRSSPTSDSLRALRALTLARKPYARQMKTVASEVSGYVESVVKERERERERLRKERQEQELANQRAKLASVQPQRTAEPSTPSTAPQEPAQSTPVESQLDSAPELRTSAPPEEPAEPESLPTVESDHSGDSLFSPPDATIDLPSTEEEAPTAVEATPALAPAPPNDAQAVDAPPVKTEPGPSSSMTFDPFSEFDSAWGQQPNGYMDTAMDYDMDFNMNMDSLGGGRTGGAGGGSFDVDDGFGVFTEDDFDFFDAPSAQRGAPVHSMPAETGSGLTPAAGPPPLGLPPLVTGDATLSGPGPPSAHMSHSSPWAGHLGDPFTPRTVGDLHGMPEHNLLPDLLPPSPSKTPSSHSAPATPGVQLTDAHKAQDGRKSSLSALGPSIFDPIPFAPSHRQMDGKYAVGKFALPSPPPDMDPAEAAMYSHAVAQGLKGWRFKYNAATDPRIGVVKKLIGTKRKGMDQGVREQRRASAWDYYREPEDWQSSSPPSAGVVDSEESDDDQWMEDEETTTLAPRPSTPPPSYLPLGPTLLQTHFHHAHLLPLCTTLRPPGTTVASPPGSAPPISVPTPVSPAAVLGAASEKSKSLEAAAQILVKEVVENPTWAEAWRENAAVALTPPVPPAKVWQADARYISSLIAAGEAAKAPTTVQELFSGSSETESVVSLRPMTPPMLAVGKDEAIIQLSPTSLRFWEKLGLAPRAGPKDITAFVFYEGSDEERELEIEGWLGKVSAAYAAKGFGSHVAGISSHCTKPGLVPTRFDTLRKTLMSFVSTIPTRHPHLAFYIATPSHIISPSSTVLRQILSAVRRFYKANPGGDILIHFVPETLIEGIHTHPASSLGGLDDFVCSVYDRTLVPVTRAMSRKFFAHSAPLVGYFEAPAYALNCTRGSGLGPGTAAPQVSFALESSVSSLDVMNRHMLLHVGYQVSSCGRWISAACVDAEGEAHELKTWLTPDDGVEAFLVREVWCFVHEFAKRANIEWRIVISKLGIMTHSEIDAWVSYLDSAVAMSSEVPPFHVTLLAVDTEHSFTFVSPFDSGPLDILTRSSTTTTSPKSSARTSHATFSDISYASYTLTTKSSLILYPAYTADRSPKCVPPALVPGASDLPYIPDFDDDSDVNGVTQRQQPFVDALRVPGWTIVICAPSVTDHTSVSTMRIFELHVTRSLRSTYEISSKKNTVADPAQAHAEHMDDIVRSFHDLAVLARARWKLRTHPALPFHLAALEAMRAALSSGNPDPPEK
Length1433
PositionKinase
OrganismTrametes coccinea BRFM310
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Polyporaceae> Trametes.
Aromaticity0.07
Grand average of hydropathy-0.286
Instability index60.19
Isoelectric point5.54
Molecular weight153732.07
Publications
PubMed=26692083

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13937
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.30|      40|      42|     468|     507|       1
---------------------------------------------------------------------------
  478-  522 (63.18/20.21)	PPLGLPPL.VTGDATLSGPGPPSAHMSHSSP.waghlGDPFTPRT.............VG
  523-  577 (44.34/11.95)	DLHGMPEHnLLPD.LLP.PSPSKTPSSHSAP...atpGVQLTDAHkaqdgrksslsalGP
  715-  753 (45.79/12.58)	PPSYLP.L...GPTLLQT....HFHHAHLLPlcttlrPPGTTVAS.............PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.94|      29|      35|     309|     341|       2
---------------------------------------------------------------------------
  310-  337 (45.23/15.44)	.EPAEPESLPTVESDHSGD..SLF.SPPDATI
  345-  371 (28.06/ 8.66)	EAPTAVEATPALAPAPPNDaqAVD.APP....
  374-  402 (44.65/12.99)	TEPG.PSSSMTFDPFSEFD..SAWgQQPNGYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.77|      18|      50|     192|     212|       3
---------------------------------------------------------------------------
  194-  212 (25.93/17.58)	RSSLLRSSPTSdSLRALRA
 1238- 1255 (31.83/11.36)	RSSTTTTSPKS.SARTSHA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.45|      16|     612|     448|     473|       4
---------------------------------------------------------------------------
  458-  473 (31.01/30.51)	APVHSMPAETGSGLTP
 1072- 1087 (31.44/ 9.27)	APAYALNCTRGSGLGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.98|      23|     610|     145|     176|       6
---------------------------------------------------------------------------
  109-  131 (43.54/19.59)	PATLCISYHTSSPS...AHARSPLSY
  151-  176 (33.44/15.21)	PAMLSFTTAASSAAdipASAATPQSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.22|      29|     244|    1091|    1122|       8
---------------------------------------------------------------------------
 1091- 1122 (41.79/46.42)	APQVSfaLESSVSSLDVMNRHM..lLHVGYQVSS
 1336- 1367 (45.43/35.59)	APSVT..DHTSVSTMRIFELHVtrsLRSTYEISS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.54|      18|     251|     883|     907|       9
---------------------------------------------------------------------------
  883-  907 (23.99/32.19)	LRFWeklgLAPRAGpkdITAFVFYE
 1141- 1158 (33.56/19.85)	LKTW....LTPDDG...VEAFLVRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.29|      12|     521|     762|     773|      11
---------------------------------------------------------------------------
  762-  773 (22.94/ 9.07)	PTPVSPAAVLGA
 1285- 1296 (25.35/10.81)	PKCVPPALVPGA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13937 with Med13 domain of Kingdom Fungi
Unable to open file!