<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13930

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMATPQTRTHQSVRSTPFGVHTHTHTGGHGPATTHTYTGPGGPASSQAGGNSQAPYPGVGGGVGGPARGLFPPPPPYYQHYTHENLQLAAERQRLESEGHDPSAHATDHPLPPLAPPPPLTDAYSILSTSFHPTYVRPTLASAGIPTLTSTPPLPKPLEIRKLVLSAALQHARLLDALARDPQSEIASLAVDRLQAILVNAMHMLGEYREHQALETLRLAMDKTVWESRQVSTTLKGTEAGAREVIAQVLGLLHQGGGQGDKESEVEREAGRVVERRRRAELDGMEGIEGGEDQSEEVKASQVEWWARQDTDQLLWDAVKSV
Length321
PositionMiddle
OrganismCatenaria anguillulae PL171
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Blastocladiomycota> Blastocladiomycota incertae sedis> Blastocladiomycetes> Blastocladiales> Catenariaceae> Catenaria.
Aromaticity0.05
Grand average of hydropathy-0.552
Instability index50.98
Isoelectric point5.96
Molecular weight34593.17
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. 


ECO:0000256	RuleBase:RU364060

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13930
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.09|      17|      17|      40|      56|       1
---------------------------------------------------------------------------
   18-   37 (26.23/ 9.04)	GVHTHTHTGGHGPAtthTYT
   40-   56 (31.78/12.34)	GGPASSQAGGNSQA...PYP
   59-   75 (33.09/13.12)	GGGVGGPARGLFPP...PPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.26|      31|      37|     110|     140|       2
---------------------------------------------------------------------------
  110-  140 (57.46/30.61)	LPPLAPPPPLTDAYSI....LSTSFHPTYVRPTLA
  144-  178 (46.80/23.66)	IPTLTSTPPLPKPLEIrklvLSAALQHARLLDALA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13930 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MATPQTRTHQSVRSTPFGVHTHTHTGGHGPATTHTYTGPGGPASSQAGGNSQAPYPGVGGGVGGPARGLFPPPPPYYQHYTHENLQLAAERQRLESEGHDPSAHATDHPLPPLAPPPPL
1
119










Molecular Recognition Features






MoRF SequenceStartStop




1) EVKAS
2) IRKLVL
3) PYYQHYT
296
159
75
300
164
81