<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13925

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHSPGRQHAQHQDGPTARTLANLRVAGSCSCHLACSSHSDHVPSDHGDADAHHSSPHDGPHPPPCPHEHQPHLGDMVPASAVIRRTAHHLHQALTLLATAAAPPSRHHNQQQLLHQHQQFPHHYASSDKIRRDLIGLVQLAHRLLAKLAAGLSWAQHVSSAYVLSQSLWAHVQRVDVALKQSLDKMRHLNLLIAAAKHANRNPDVPTAAVVLSTGCYPFLPSPEAVFPVARGAHHHAPQHIWQHSRLDKDVDPHDPDDIDPVLIDHLNDAIRSRLILHECTVPPVFMAHHHIDGGLVSFSVPNEFAVTLSLPGGFDPTIPWTLVTLDLLDPSIFQHFDSERRTKVHEHLQERDRPWPARTTPPSTPPNLPSPFDLPLIELYHMLHHIFLSMRLEALYFQAGTRDRSSGALAAIGDPEFDLASKSMHIRLWWGTFNAQSIFISTTTAAQELLFNASQHSSLSPVPLLSTTPTLCAVGAKKATSSTLHFQSTNLVMQFGPLRISIPPRISLESLVTWCMSDYAPSALVTQNRLAGDHIILPDHGLAIAIHRTTGQFSVVPLDRFHTDLKLVLDMLNKAPWALPEILHALTMSQRLGNLEASLSFDGLEPCPQDTPLTPNNRIVIDGLDLGPIRLARVLQLPYDPEYRLYLSMETFPTTKAFIVRWGPEEKRIIHEFFYGPACTSWNGAWLKIDPSAILLRPAIQLMVSFMSVTVHVNSRLPLTLTILFSRSIPGLSSALLTKSCPSVSELINYTFKCFGLVSLLAFLPTAATSIGRANFDSCTIDLNLPTGDSVTLQPTDPLVIKTPSSTALPGVRFPPFESTNPHIALPEHPESCLVVQGPKSPQGRDVAVSLVFAIPSPRVVSGPEYVPLVYSWSGSVVSPWDSKDGFEGSDDDDMIMNPSAVLAMLGMGDANSSPKGSDEASAATNGSGSMHELKPTVHELLAEIKGESITQSTSEDSLLWSLTRLIQRWRGT
Length974
PositionTail
OrganismCatenaria anguillulae PL171
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Blastocladiomycota> Blastocladiomycota incertae sedis> Blastocladiomycetes> Blastocladiales> Catenariaceae> Catenaria.
Aromaticity0.07
Grand average of hydropathy-0.112
Instability index54.90
Isoelectric point6.32
Molecular weight106830.56
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13925
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.08|      35|      53|     226|     261|       1
---------------------------------------------------------------------------
  226-  261 (64.99/36.21)	VFPVARgAHHHAPQHIWQHSRLDK.DVDPHDPDDIDP
  282-  317 (61.09/29.86)	VPPVFM.AHHHIDGGLVSFSVPNEfAVTLSLPGGFDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.41|      14|      35|     568|     581|       2
---------------------------------------------------------------------------
  568-  581 (25.11/13.38)	LVLDMLNKAPWALP
  600-  613 (25.64/13.82)	LSFDGLEPCPQDTP
  620-  633 (21.66/10.45)	IVIDGLDLGPIRLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.77|      37|     188|     638|     685|       3
---------------------------------------------------------------------------
  638-  685 (58.49/66.24)	LPYDPEYRLYL.............SMeTFPTTKAFIVRwGPEekriiheffYGPACTSWNG
  827-  876 (62.28/39.50)	LPEHPESCLVVqgpkspqgrdvavSL.VFAIPSPRVVS.GPE.........YVPLVYSWSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.93|      57|     188|     494|     559|       5
---------------------------------------------------------------------------
  494-  559 (89.11/71.16)	MQFGPLRISIPPRISLeslvtwcMSDYAPSALVTQNRLAGDHIIL.....PdhGLAIA............IHRTTGQFSVVPL
  688-  761 (82.82/46.79)	LKIDPSAILLRPAIQL.......MVSFMSVTVHVNSRLPLTLTILfsrsiP..GLSSAlltkscpsvselINYTFKCFGLVSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.67|      40|      53|      87|     132|       7
---------------------------------------------------------------------------
   63-   85 (27.55/ 7.78)	................PPC..PH............EH.Q..PHlgdMVPAS.AVIRR
   87-  132 (71.39/44.01)	AHHlhqaltLLATAAAPPS..RHHNQ....QQLLHQH.QQFPH...HYASS.DKIRR
  141-  188 (48.73/21.30)	AHR......LLAKLAAGLSwaQHVSSayvlSQSLWAHvQRVDV...ALKQSlDKMRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.38|      19|      19|     778|     796|       9
---------------------------------------------------------------------------
  778-  796 (33.50/17.16)	DSCTIDLNLPTG.DSVTLQP
  798-  817 (29.87/14.51)	DPLVIKTPSSTAlPGVRFPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.43|      24|     256|     190|     220|      10
---------------------------------------------------------------------------
  190-  220 (29.09/29.21)	NLLIAAAKHANRNPdVPtaavVLSTGcyPFL
  449-  472 (43.34/20.24)	ELLFNASQHSSLSP.VP....LLSTT..PTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.29|      19|      25|     883|     901|      11
---------------------------------------------------------------------------
  883-  901 (35.33/24.56)	DSKDGFEGSDDDDMIMNPS
  911-  929 (31.96/21.46)	DANSSPKGSDEASAATNGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13925 with Med14 domain of Kingdom Fungi
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