<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13920

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDQSEGSQTVWNNVSIQGSDIGSSFGNTTQFNSGPGNEGNTTSNSVQVDNQVANAVASNASYQLSIDMQNDNSDMMSGLMDMNSMLGLYGGADDLGDWDEVTKDDFSFFDEAGGRYVYRRLYKCRRSSIPNPFNQQRRPSRMLPFYQPGKDQEWIMPAKKEKPRKTKSRMFSISFNWNSVKWQDQASKLETIKQNKSTSEKATAGNIPTVSATAWGISTLSLQQPAKRKMEESSSSDSDSDSTSTWSEESDDDTAVEPNRPAFGKLSRRFYLYDGNGHANAIRNSNGINKEAQEPWSARGINSAKFTNAVLTQSLDQSVGGALLGLRTSSTTHTQARGVTPSLARLDRIAPFYEHQRSKPWSSAEAYHAEVEFDTPFTPAVLSAAPPALVDEPLVVQDSLASEYFLEAVKTLCEQAVMGDYPFAGSNEVTGTSGEISEGESFHVMLARRKAMSELLRTGIATVPALGDESFRNIMEMKSFIFELFDHLRGNQSENTVALPIPSDASQDMTMSMATIHGHHHHSSQNNISPPVVMKGPLTLFQYFSLAEAQQMPSKYGKYPVKKKKPAEPSLVQLQPPDIVVGHNEEWLEAAPTILRFWEKLSLEPYSAKKNISYFVVYPEGDEMESSVIYPSTFGGYLRFGLRDIAFTVYTKCKLFLERPTYSEGIMAQINSYAPSFALARTTPVMIQYDVNLKPNSTPKPPATMHVGYGFSLDGRWLVCVWTDHRGEMLEHMALDMMDSSARLLTIAQPKGGQGLLSNYLHEIWTRTLVYKKRGSFSWKTIVCKLGLMTRVELQEWARLVCDDNDTAITAVNIDSPLRMYPHSRGAEYLSSNMTSGVNGSNTPIILGIGQTGASVIGAGPMGLNTTNPTATLTPDVSTAPATPSNSGVTGLGIVGTGSNPSGTTAGTSSTMSGANRLSGSEVLENSVGQVYAMILNHRIPLIVSHEETAFRIPALAQSGLSTLRTESGNEFRRSPEESKGDISTEDDLLREHIGADLSMNQNQNQNQSQSQDIKTHLKMKVEELDQQWQQKELRKEMDQDTKAPSTRLSLPLSDNDVILPLSTGYLIQVPTQANSVMREKHSLEALGIEVHLLHLQRTTSPLGPASAPASATNTPIPSVSTGTLLSNYNANLPYQQSSPSYHLPRHSAVANTNTSVSGQPYRSPSFASIQYPGSPLVGSSPSSTLPGGHSQQPHQQQQQQQQTSTNNGVGATTIETATAANTTREILKQFHALSHLSMSPVQTNCLPHHLILVERLTRVLLLVQDA
Length1267
PositionKinase
OrganismLobosporangium transversale
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina> Mortierellomycetes> Mortierellales> Mortierellaceae> Lobosporangium.
Aromaticity0.07
Grand average of hydropathy-0.467
Instability index47.86
Isoelectric point5.88
Molecular weight138794.71
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13920
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.73|      29|      63|    1044|    1105|       2
---------------------------------------------------------------------------
 1044- 1083 (41.02/71.36)	AP..STRLSLP.......LSDNDVILPL...STGYliQVPtqansvmreKHS
 1108- 1148 (40.72/11.90)	APasATNTPIPsvstgtlLSNYNANLPYqqsSPSY..HLP.........RHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.60|      36|      61|     518|     560|       4
---------------------------------------------------------------------------
  518-  560 (57.98/43.03)	GHHHHSSQnniSPPVVMK..GPLTLFQYfslaEAQQMPSKYGKYP
  582-  619 (58.62/29.27)	GHNEEWLE...AAPTILRfwEKLSLEPY....SAKKNISYFVVYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     131.47|      30|      30|     843|     872|       6
---------------------------------------------------------------------------
  806-  842 (32.90/15.50)	DTAiTavnidSPLRMYPHS.R..GAEYL...SS...NMtsGVNGSN
  844-  868 (35.06/17.03)	...........PIILGIGQ.T..GASVI..GAG...PM..GLNTTN
  869-  900 (36.96/18.38)	PTA.T....lTPDVSTAPA.TpsNSGVT..GLG...IV..GTG.SN
  901-  940 (26.55/10.98)	PSG.T.tagtSSTMSGANRlS..GSEVLenSVGqvyAM..ILNHRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.09|      41|      67|     157|     201|       7
---------------------------------------------------------------------------
  157-  201 (61.30/48.55)	PAKKEKPRKTKSRMFSISfnwnSVKWQDQASKLETIKQNKSTSEK
  225-  265 (68.79/42.62)	PAKRKMEESSSSDSDSDS....TSTWSEESDDDTAVEPNRPAFGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.19|      11|      72|     351|     368|       8
---------------------------------------------------------------------------
  144-  154 (24.55/ 7.21)	PFYQPGKDQEW
  351-  361 (24.64/24.05)	PFYEHQRSKPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.65|      11|      74|     384|     394|       9
---------------------------------------------------------------------------
  384-  394 (19.32/11.87)	AAPPALVDEPL
  461-  471 (18.33/10.83)	ATVPALGDESF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13920 with Med13 domain of Kingdom Fungi
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