<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13916
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MDPWNMEETNSNTEMLVAVDLMYLTYTMARIRPVVPDIFVVQRLKDMKKIKALEMDVVLLQFWLAGLTGLAESTTLSQRLIWKSLVSVKIPYIVSQFGLPQGEICSLVESALRQLSFYRGILNECDQSIAGDSTVEQLDVLRAIAVGCITKGLIRPNQLHVPHGLTSFQDTSDDYCAINHSSLDLIDDLCGRTLSDFVHQEKLVNRIIQVCRDAGFRNDVPVLSRLCQTLDDNPLVLDLIHFLQPPSALLVPLEGFVNNFQHSLGDDIDTCNSNLEGLGTVLILIMTIIRRYELASCLNSIFKEKQGFCYLWLHRTSAVIPATSMSSMSADMHSLMGRWVSALFDSMGISDDLIQTSKPQMLLEISPSIFAQSLAACQAGVIDITTLNSGLDYFLQPCLLFVLVGVVQFLCQEILFSSSVSSPDSTKAHLPSAQPASGLIHAHSSNMLSPTGHIVSPLAAKGIRPVHHSSQSNTMHSHGNGKTVAAVAMLQTILKSLLTGEAFPTRLMRLLKSEIQAALEHQTVDNNDRQMAIIQERLAAASLNYYPWSVSGTYDVPKLAQQTSLAFEAIALGGRTSIVTRKEKGWPVFGESCYHIDVDLFRATLCHLGPAQFATTILKQLLKTAMTPNGKRAVELGAAMMTTPLIGCGDQHLAPQSLVWTLMYRTLWIPVPGRLETFSQGRLLAAFVGMTLDFFQSHNLIQLREKQQRRRQQRQDANSLVEMSSFQGEASKTKYKDHTLEQLERDTAVEYYRVMLDQRLHELKPVAKDRPGFEGFAQGMALYKECHQSMSLPLHQSRKVRR |
Length | 802 |
Position | Tail |
Organism | Lobosporangium transversale |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina>
Mortierellomycetes> Mortierellales> Mortierellaceae> Lobosporangium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | 0.004 |
Instability index | 45.42 |
Isoelectric point | 6.58 |
Molecular weight | 89292.19 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13916
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 335.53| 106| 113| 238| 349| 1
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238- 349 (171.94/140.30) DLIHFLQPPSALLVPLEGFVNNFQHSLGD..DIDTCNSNLEG.LGTVLILIMTIIRRYELASCL..NSIFKEKQGFCYLwlhrTSAvIPATSM.SSMSADMHSLMGRWVSALfDSMGI
352- 463 (163.59/113.36) DLIQTSKPQMLLEISPSIFAQSLAACQAGviDITTLNSGLDYfLQPCLLFVLVGVVQFLCQEILfsSSVSSPDSTKAHL....PSA.QPASGLiHAHSSNMLSPTGHIVSPL.AAKGI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.03| 13| 20| 506| 518| 2
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506- 518 (20.38/14.31) RLMRLLKSEIQAA
529- 541 (20.65/14.60) RQMAIIQERLAAA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.78| 13| 119| 492| 504| 3
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492- 504 (22.85/14.85) TILKSLLTGEAFP
616- 628 (22.93/14.93) TILKQLLKTAMTP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 79.36| 24| 487| 142| 165| 5
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142- 165 (44.33/28.09) RAIAVGC..ITKGLIRPNQLHV.PHGL
632- 658 (35.03/20.72) RAVELGAamMTTPLIGCGDQHLaPQSL
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