<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13903

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMNTPFPQTEVNIEALENVKTRLFQLQESILFFLRSINPETTPGTVSWTELHSKFNVLIAKYLHLTNLVNDPHNTLLQSYTVFPNEAPATDQHVQNLSVLLRTKLLPELEQEAEDRIKEGTIPGLNSQGGGVAEDRKVLQALKLKVTMHDALCQAADEIFENQRDMINTRVRYESDDEGQGDINSKTTQRSGDKMKEPSSNSNTVPPVDDFAIGMVDNATSIRYMSEWGGTLHDVDGYTSDESADEAAITGIPKNGIDLDDSYFEARRQDFSSGDEESSQSDMESVQDDQGSEDIQEDEDKDEEEEEEEEEEEDDEDTFMEVRTGSQPIDVDSGPSSMQMAEDVFHEDAGNSGDEEEMEEVM
Length361
PositionHead
OrganismLobosporangium transversale
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mortierellomycotina> Mortierellomycetes> Mortierellales> Mortierellaceae> Lobosporangium.
Aromaticity0.06
Grand average of hydropathy-0.846
Instability index57.21
Isoelectric point4.06
Molecular weight40465.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364144

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.41|      16|      17|     160|     176|       2
---------------------------------------------------------------------------
  160-  176 (24.59/23.23)	ENQRDmINTRVRYESDD
  177-  192 (28.82/20.87)	EGQGD.INSKTTQRSGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      61.64|      16|      17|     100|     115|       3
---------------------------------------------------------------------------
  100-  115 (24.19/14.72)	LRTKLLPELEQE....AEDR
  116-  135 (18.87/ 9.99)	IKEGTIPGLNSQgggvAEDR
  143-  157 (18.58/ 9.73)	LKVTMHDALCQA....ADE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.68|      24|      42|     288|     316|       5
---------------------------------------------------------------------------
  288-  311 (42.25/20.41)	DQGSEDIQ..ED...EDKDEEEEEEEEEE
  331-  359 (34.43/ 8.63)	DSGPSSMQmaEDvfhEDAGNSGDEEEMEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.59|      16|      17|      57|      72|       6
---------------------------------------------------------------------------
   57-   72 (27.95/18.00)	LIAKYLHLTNL..VNDPH
   75-   92 (23.64/14.28)	LLQSYTVFPNEapATDQH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13903 with Med8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IRYMSEWGGTLHDVDGYTSDESADEAAITGIPKNGIDLDDSYFEARRQDFSSGDEESSQSDMESVQDDQGSEDIQEDEDKDEEEEEEEEEEEDDEDTFMEVRTGSQPIDVDSGPSSMQMAEDVFHEDAGNSGDEEEMEEVM
2) RDMINTRVRYESDDEGQGDINSKTTQRSGDKMKEPSSNSNTVPPVDDFAIGMVD
221
163
361
216










Molecular Recognition Features






MoRF SequenceStartStop




1) AAITGIPKNGIDLDDSYFEARRQDFS
2) EDTFMEVRTGSQPIDVDSGPSSMQMAEDVFHEDAGNSGDEEEMEEVM
246
315
271
361