<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13901

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPAINHPLPPRPTTSHPPPARPQGLPSPGLSLPRPPFYSSPQPASPRPSPSNYLSYQASSPKVNSRDPLPVEEPLQQVRKALDKDQLKPNCDLLELGQGWKVHWRAWRGPPLLSSASNPAPTSSKTDSSTTKYDPLATFATNPSSAAAKGADPPPAKRPKPTAFDEMMAEVDEGSVASTSTAPPLKDKLQLLQQLSFGADPVELARKEVLRLGQAPTTGGSGGQLLGLFGHVRVAAGKGEHGKGKGKEKERIEDEEPAARMLWVFSLRRGTQMGEGSDGSSRAQLSSLEFPDLTCVGKGHFSHHDLFPTLYPEATSSGSTSSSHHAPYVSPSTLPVSSFPSTLALSNEFHSDLAPTASSTSTGQAASQPQSRIKAPFEAFLAAASEALTVALLTDDNTTSRPRHTSSSTRLDSSVVYLPPPSESFGSTSRRVTSDAVKTSLHLSLQRTGILIQSTIEDLPYRPFPISSPPPPNSPLLLAPFNTAAQFVKTFPAEAKPGAVALAMEEEWKGLLEGTGLRLSGEEAWVLCRIELPSSTIPPTPDNEALPPPPPPPEPLEVVWPASLCILDGTKPQPSRSPDNTPPRMKAPELAPGAPPSPSNLPPTSTTTSYFSDKLIVPPLDTSTRRRFASVLRRGLASTTDPVYRDPISSRAERVGSMLEEQAEERQRREQAEKAAEAALKAAPVAVPPTPSSMETSKAGIPLPSVPGGLPTSTSMAGGGAAGLAGAPINMRTPISLGGSSTEAPSPADGFGSAERGLMQALGAYGVGATGGATTEPVGGTKNAEMDHLYPSPSEAMGGGVEATGGAGSAGGDQPMSAVEPQLDHSFPDFDWGDDFATGAMGGRSNMPGQGQDFDDGMMMGLTDDDFSFFDDPPPLPVSLPMNTFGGLQSSGPSPKFVDHFSHLTGTTPFASAASPTSPFGHPSPHQGLHNHASPNLVHFGFDPSQNALGLGSTPAPLHGEGYSPFKTPRTPYSPFVEITDDHETPAGFPAPTVSIAGTPANSLLPSSRRPGKFDAIHFGNSHALCDDKYDPRKGKFGLPSPDWERDQAAAAGASSSASSSATGTDRRPLPLASAPWFTTVCDPRVAAANALKRKRTPSLAKLAVQGRKGSSSSDQAARVRSREWITQDVDSEYGEDESEDEAMDVEEASALGAPGDDTSLEDHYVGGVPPISYTFGAALLLLRQHLGTLLAGKKKAPGVPVAITKALQAADTQLEQALSLVADQTMYNPDFRQRSTSASLLKSSTTCIVSPHAIQLVGARLASLTSKSTAAITPTLKETALPSLAAQRTPAILLRAQQSIMELSTAATAYWRPMGFEPLAGGKDVTAFAIYEEGGAELNAAVAAWLKMVGEAYEGSRLGKHTPGSVPATSTFAGVQDGLGVVPVGALSAPRSRDELNGLASHLVEATRSRKHVVVYLLAPSEAYTSSPASPIVLALQQVLKIKSRASHVSWVTYPLPLSSISRWRTIVAGDSSTKRLDHLAFSVYDQLLVPVSSLVFPMPETFPSANLARPQSLGPPLRLFQSPAITMSPSRDANIEFELNWPPSSLEVMHRHRLLHIAYACSPAHSQERLEWIVVSCVDEKGEIWKTVPKLLRYPPGPVEVVRARVVWSICKMLIDTADVEWRVIISKLGVPSKAEAKAWDSQLKEALAISKRPLHVSLVGVDTSPPVSVLQQQRGATPSSPSVSQTHSEEGEVAPSIGSTTSTRKPPHLDTQPSVFAFTPAEPLAVGPDSNLIAPASTYLIHVPRIASLAHTSIDPFMSSSPLVSVLGLHFLMAHHSKASSLSITLGQHVQDVRQSFVELAALGQTRWGTSGRMAWHLEAARVVLDLVEEVEGERSA
Length1840
PositionKinase
OrganismLeucosporidium creatinivorum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Leucosporidiales> Leucosporidium.
Aromaticity0.06
Grand average of hydropathy-0.300
Instability index58.25
Isoelectric point6.08
Molecular weight194666.89
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13901
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.13|      32|      32|     742|     773|       1
---------------------------------------------------------------------------
  687-  718 (38.95/10.34)	VPPTPS....S................METSKAGIPLPSVPGGLPTSTSMAG
  719-  766 (38.70/10.22)	GGAAGL....AgapinmrtpislggssTEAPSPADGFGSAERGLMQALGAYG
  807-  837 (31.08/ 6.60)	AGSAGGdqpmS................AVEPQLDHSFPDFDWG.....DDFA
  838-  866 (37.40/ 9.60)	TGAMGG....R................SNMPGQGQDF...DDGMMMGLTDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.41|      18|      19|     885|     903|       4
---------------------------------------------------------------------------
  867-  884 (23.61/ 8.26)	FSFFDDPPPLPVSL.PMN.....T
  885-  903 (30.91/18.67)	FGGLQSSGPSPKFVdHFS.....H
  926-  947 (21.90/ 6.95)	HQGLHNHA.SPNLV.HFGfdpsqN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     157.77|      31|      32|     114|     144|       5
---------------------------------------------------------------------------
  126-  157 (41.17/10.89)	TDSSTT...KYDPLATFATNPSS....AAAKGAdPPPAK
  394-  423 (41.29/10.95)	TDDNTT...SRPRHTSSSTRLDS....SVVYLP.PPSE.
  546-  576 (40.11/10.41)	LPPPPP...PPEPLE..VVWPASlcilDGTK...PQPSR
  577-  607 (35.21/ 8.16)	SPDNTPprmKAPELA.....PGA..ppSPSNLP.PTSTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.73|      21|      32|    1303|    1324|       6
---------------------------------------------------------------------------
 1303- 1324 (37.12/23.33)	ELStAATAYWRPMGFEPLAG...GK
 1338- 1361 (33.61/16.59)	ELN.AAVAAWLKMVGEAYEGsrlGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.95|      25|      32|    1716|    1745|       7
---------------------------------------------------------------------------
 1482- 1502 (28.88/ 6.04)	....AFSVYDQLLV.PVSSLV.FPMPE
 1505- 1528 (33.30/ 9.00)	PSA...NLARPQSLGPPLRLFqSPAIT
 1716- 1741 (39.77/25.33)	PSVfAFTPAEPLAVGPDSNLI.APAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     113.93|      19|      19|     290|     308|       8
---------------------------------------------------------------------------
  267-  287 (22.26/ 7.74)	LRRGTQMGEGSdgSSRAQLS..S
  290-  308 (37.86/18.40)	FPDLTCVGKGH..FSHHDLF..P
  311-  331 (27.62/11.41)	YPEATSSGSTS..SSHHAPYvsP
  339-  355 (26.19/10.43)	FPS.TLALSNE..F.HSDLA..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.04|      20|      21|       8|      27|       9
---------------------------------------------------------------------------
    1-   24 (33.86/11.37)	MPAinhpLPPRPTTSHPPPARPQG
   25-   48 (36.18/12.76)	LPSpglsLPRPPFYSSPQPASPRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.15|      26|      33|    1168|    1198|      10
---------------------------------------------------------------------------
 1168- 1194 (41.58/34.49)	GVP.PISYTFGAALLLLRQHLGtLLAGK
 1199- 1225 (38.57/17.62)	GVPvAITKALQAADTQLEQALS.LVADQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.21|      12|      18|    1262|    1273|      11
---------------------------------------------------------------------------
 1262- 1273 (18.96/10.81)	LASLTSKSTAAI
 1282- 1293 (21.25/13.30)	LPSLAAQRTPAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.24|      20|      33|    1005|    1037|      12
---------------------------------------------------------------------------
  369-  388 (33.30/ 6.22)	PQSRIKAPFEAFLAAASEAL
 1006- 1025 (37.95/38.90)	PSSRRPGKFDAIHFGNSHAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.60|      13|      15|     967|     979|      13
---------------------------------------------------------------------------
  967-  979 (24.45/ 9.54)	KTPRTPYSPFVEI
  984-  996 (25.15/10.06)	ETPAGFPAPTVSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.33|      11|      32|    1530|    1543|      18
---------------------------------------------------------------------------
 1530- 1543 (16.44/17.95)	SPsrdANIEFELNW
 1564- 1574 (21.90/12.76)	SP...AHSQERLEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.45|      10|      16|    1764|    1773|      19
---------------------------------------------------------------------------
 1764- 1773 (17.78/10.21)	SPLVSVLGLH
 1783- 1792 (17.67/10.09)	SSLSITLGQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.89|      16|      34|    1039|    1054|      20
---------------------------------------------------------------------------
 1039- 1054 (30.89/17.32)	LPSPDWER...D.QAAAAGA
 1072- 1091 (18.00/ 6.46)	LASAPWFTtvcDpRVAAANA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      16|     999|      55|      70|      21
---------------------------------------------------------------------------
   55-   70 (31.20/14.21)	SYQASSPKVNSRDPLP
 1056- 1071 (28.46/12.15)	SSASSSATGTDRRPLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.33|      22|      34|    1400|    1433|      23
---------------------------------------------------------------------------
 1400- 1421 (35.78/41.01)	LASHLVEATRSRKHVVVYLLAP
 1435- 1456 (37.56/15.31)	LALQQVLKIKSRASHVSWVTYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.74|      15|      15|     208|     222|      24
---------------------------------------------------------------------------
  208-  222 (25.17/14.43)	EVLRL.GQAPTTGGSG
  224-  239 (18.58/ 8.31)	QLLGLfGHVRVAAGKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.86|      15|      43|     906|     920|      25
---------------------------------------------------------------------------
  906-  920 (28.44/12.70)	GTTPFASAASPTSPF
  952-  966 (30.42/14.22)	GSTPAPLHGEGYSPF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13901 with Med13 domain of Kingdom Fungi
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