<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13900

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAINLYHFTSTVITLLSNTTTTTTTNPPTAESVPDYSHELPTVLNDLIPLSHILDRIISQAHHDLANLTETLPSAPDQARKRAIVDYVLQTRRQILKLLVLVRWSSEAENLAKCMNIIGFLGRQNDEFDNSITSLTSVKSQLSQARIRNSDLPTSLTVLRTGNYSALPAVVREGFEQPEKLSDETVLKTLEEVEEVLRWRLGAGREVLPAGMRGWWIADGRVHFRVPGMWEASFTYGGGMDDPSDLDLADADAEEGADSVGQGPAQGAEWYLLSLKFLFRVRDARGVWSPTPTGPMKEHIIDLCNRELARRRGPSPPPPATGEEASGAAPPAPKKRRDTPLVRGYNFLQRLALSYQLESLHQQALQLANTSWSSSLKIEMNRERTELRVGYWCPPKPDVPPTQPNRAPSQPLPPPPSAPATLIFSLSTSSSSSSSLSREKVLERILEGKQEGEEGEEEVVGEKLGVEWKAEGVEEVRRGLGELELDSDLSLEILLLTLTTSHATTLTHQLYQHLLSIFPSTSSSLELIYPSLSCTTTSPPSAEGEENNNPAQLPSIHLHLFATHSLTLSLSPLTGRLSLISPSELSLTRETRLRSAADKINAAAWAPGGGGGGGGGWAATMQSASETLVRVRASTILDEVESRAAVLGLQTTRRLPLRSIDLARFGADTRSCLFVRLSLSSPSGGGGGAGAGAAGAGEQHYLVLVMSEQGFRFALIGTREGSDGVQSWVGIGEVGWVELERGGRTEGEGGEAMGRPEGEGGGVHGFDVTIEDLRELHSYCLHRLASHHLERQLHSRRIPFLTISPSPTPALTPTTTTATTSTTKQTPYLLIHSKDLLAATAEGLGLGAGAGAAKGGAGALAKAAFDNVAVRCSVRGEVVRLERELGDCSAGGAS
Length894
PositionTail
OrganismLeucosporidium creatinivorum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Leucosporidiales> Leucosporidium.
Aromaticity0.05
Grand average of hydropathy-0.268
Instability index51.35
Isoelectric point5.61
Molecular weight96130.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13900
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     312.87|      73|      73|     607|     679|       1
---------------------------------------------------------------------------
  585-  646 (80.45/35.53)	..LS.................LTRETR...LRS......AAD...........kinaaawaP.G.GGGGGG...GGWAATMQSA......SE.....TLVRVRASTILDEVES.RAAV
  647-  731 (99.82/45.78)	LGLQ.................TTRRLP...LRSIDLARFGADTRSCLFVRLSL......ssPsG.GGGGAG...AGAAGAGEQHylvlvmSEqgfrfALIGTREGS..DGVQS.WVGI
  734-  800 (82.03/36.36)	VG..............................WVELERGG...RTEGEGGEAM......grP.E.GEGGGV...HGFDVTIEDL......RE.lhsyCLHRLASHHLERQLHSrRIPF
  801-  878 (50.58/19.71)	LTISpsptpaltpttttattsTTKQTPyllIHSKDL...LAATAEGL.................gLGAGAGaakGGAGALAKAA......FD.....N.VAVRCS.VRGEV.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.76|      12|      69|     330|     341|       3
---------------------------------------------------------------------------
  330-  341 (23.55/11.61)	PPAPKKRRDTPL
  401-  412 (23.22/11.34)	PTQPNRAPSQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.92|      31|      93|     423|     458|       4
---------------------------------------------------------------------------
  426-  458 (45.11/32.40)	LSTSSSSSSSLsrEKVLERI..LEGKQEGEEGEEE
  515-  547 (48.81/22.05)	LSIFPSTSSSL..ELIYPSLscTTTSPPSAEGEEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.54|      15|     280|     179|     204|       5
---------------------------------------------------------------------------
  179-  196 (16.89/11.92)	EKLSDEtvLKTlEEVEEV
  462-  476 (26.65/ 8.64)	EKLGVE..WKA.EGVEEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.60|      39|      53|     209|     250|       6
---------------------------------------------------------------------------
  209-  250 (70.56/42.90)	PAGMRGWWIADGRVHFRV...PGMWeaSFTYGGGMDDPSdLDLAD
  264-  305 (71.04/34.87)	PAQGAEWYLLSLKFLFRVrdaRGVW..SPTPTGPMKEHI.IDLCN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.78|      10|     302|     496|     505|       7
---------------------------------------------------------------------------
  496-  505 (18.00/ 9.58)	LTLTTSHATT
  811-  820 (17.78/ 9.36)	LTPTTTTATT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13900 with Med14 domain of Kingdom Fungi
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