<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13879

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSEDKMDVSPLANHHPDAASSTTEAPTHKIAKLPDPPAIPHINERFIPLSHVVSALVRTAMLELRQLRDVTADLSDQKRKRRIIDYCSAFKTEFVKVLVLVDWAKNADDVHRAIDVKAWLQGQRNCFDNLYGSLRWDVLRSMEHAKLRNPDLLGAVDVLKTGSFPRLRQSELARQYRVLPPIKPRQVLRTMQAMNALISLRLQLYETLPWPMRHFTISSGRARFHIPDAFTADLSFASEDVELPALTWFLIDFSFASETPDTVKLEIEAMSNALMSQAQAEGRPQLVSLYNRLHSLLVLYKLERLFNQFSALDPRQRKLVDVKYASAERKMVVGYWLDQRASEGHARNSFTVSIAAVSVPAKARLLKSQRHSLDYNTDALVAYRRDDSGEDRPLLFTLDGLDASSLLESVLAMHQTQNLTALKDALRLRCTLNDAELVVRLSDTNQLCISVDASNGQFVVYRLGEPGPIRIQNTQIATLRRQINGSSNVGEQAAFVRQYQLAVARHELEQAATLACWTLFRFTQVAFERDDFQRAFSGAQAKDCLFLTRAQEGWQETSVERSAWFVVATFARVGPDVSVQLYLAECQVDEERGWYIQWTEALEPVKAEVSFDWQRIWRFSTARILLLQLSRALTERGCQYRFVAGKSPWRTIRVPALRVAAKDMPPGRRIWSGDATWTLTRVGEECELSLQAQKLLATQLDLGALESNGQLNITRRVTVRDGIAAAVSEVLDVWRQVEDRICRIESISRLSGRLDIQASSLASLVLSYGSYQLNIGEDTLALSTAMPGLLNPHERVLPLLQALYTRYASILVLGETLLATLPALEAFTLLEQQTFLSPSCYIVTRSLSLYRIYYPTRQAGLEIQLRPQPSESLMSTSGTSLEGAAEWLLLDLASLGVEASVRFCSVAHKVGFKAMTLASHATNVFGLQIPADAQGDASLSSTLMRIHDGIMQIPERNAAVFGIPQESPRKKGPAARRVSKASTTASKKPGVTNGREVIEL
Length1000
PositionTail
OrganismProtomyces lactucaedebilis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Taphrinomycetes> Taphrinales> Protomycetaceae> Protomyces.
Aromaticity0.08
Grand average of hydropathy-0.146
Instability index39.59
Isoelectric point8.65
Molecular weight111999.94
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13879
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.66|      20|      23|     464|     484|       1
---------------------------------------------------------------------------
  464-  484 (29.93/20.42)	GEPGPIrIQNTQIATLRRQIN
  490-  509 (32.74/17.87)	GEQAAF.VRQYQLAVARHELE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.48|      10|      18|     230|     239|       3
---------------------------------------------------------------------------
  230-  239 (18.96/ 9.78)	FTADLSFASE
  249-  258 (19.52/10.26)	FLIDFSFASE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.67|      38|     319|     557|     594|       4
---------------------------------------------------------------------------
  557-  587 (47.81/30.05)	.....................TSVERS.AWFVVA..TF..ARVGPDVSVQL..YLAE..CQ
  588-  639 (34.91/19.72)	VDEERGW....yiqwtealepVKAEVSfDWQRIW..RFstARI...LLLQLsrALTErgCQ
  643-  690 (35.95/20.55)	VAGKSPWrtirvpalrvaakdMPPGRR.IWSGDAtwTL..TRVGEECELSL..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.17|      38|      44|      74|     116|       5
---------------------------------------------------------------------------
   74-  116 (53.75/48.83)	LSDQkrkRRIIDycSAFKTEFVKVLVLVDWAK.NADDVHRAIDV
  120-  158 (64.42/41.23)	LQGQ...RNCFD..NLYGSLRWDVLRSMEHAKlRNPDLLGAVDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.95|      12|      19|     285|     296|       6
---------------------------------------------------------------------------
  285-  296 (20.14/12.46)	QLVSLYNRLHSL
  301-  312 (19.81/12.13)	KLERLFNQFSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      13|      19|     422|     435|       7
---------------------------------------------------------------------------
  422-  435 (18.33/15.65)	LKDALRLrCTLNDA
  441-  453 (23.09/14.24)	LSDTNQL.CISVDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.90|      64|      65|     860|     924|       8
---------------------------------------------------------------------------
  860-  924 (102.90/80.46)	GLEIQLRPQPSESLMSTSGTSLEGAAEWLLLDLASLGV..EASVRFCSVAHKVGfKAMTLASHATNV
  926-  991 (104.00/75.86)	GLQIPADAQGDASLSSTLMRIHDGIMQIPERNAAVFGIpqESPRKKGPAARRVS.KASTTASKKPGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.95|      27|     422|     378|     408|      11
---------------------------------------------------------------------------
  378-  408 (35.76/32.34)	DALvaYRRDDS....GeDrPLLFTLDGLDASSLLE
  801-  831 (42.19/22.74)	QAL..YTRYASilvlG.E.TLLATLPALEAFTLLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13879 with Med14 domain of Kingdom Fungi
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