<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13876

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSVQDHLPPLLEADRLTSILRVLAVTQAQWTTWCASDSTDVQALTRIEIDLRSQGALVKRIGQELWHFVLSEDDKDTKQSRLSTQPLKEIGQEQRLDLSEVGFSTADMSNATDLFIALRILKEALVLQLTYRCAKAGFVPLGPCLLSPLPELTEHSFDENLCLKPLPNGRYPGPQRQCIMSLHLAVSGDLTLALAKTDVQLIALDMHSKQLEAGDPVYLAPSGHKATLVEYSFELSSEAYRLQLTKLIGFQLLDTSRWVRVHLGDESFLWPSALTFVPYTALQVKPPPESWFGLKDTWLAQCKSDMERKVQKQKEMDANESTDNLMPDATVEPAVSEQRPASAQKPGSKDDSHHVYPTPPDATPGPFLKKASHDSDDEDMHVTDADFSFFDRNSPEVIMQEIESINHLPTPMETDMRTQAPVSAQPTEPPTASFDMITPASQFGATPNIVACEADKAAASVREVYRRYRQPVPSHFTPMSLAQQHNHYGPGGKYYAGSSASSADNAPSSDEEMTDDAYDRERATSSGHVKALLDDLVSEAEFDPPPPNIPWHLVSPRIASNPIKSTHLSLRSQLEKLALPTKEEADLIDLVGSLLCGPNIAGFRETSILPAASFNTDLYDLDWFSDSDMENVISCCKSTFGQAPMQLKLDDVATIYEDPKSSNAFKPKNSQRKNHPAGLASHVTLLREPRVLLSRAHIDEKTHKEIMEDYEMSTSAIRLWYTAQLSPLDGPKDAVHYVFYPEGELLEHAAFRYLDDLRALYYGCNLGQFLYEDKVEDSYLPFRLDDNSSSLSNGFNKIQKYWQKDTKTGHSAECLNIVLHFFNPFELSDLAFLSFLNMVTKYKKKSIFMHVALQVVDVDQVCKVDGFKALRIKECVALCLQVYNRCQLTATDSDPKLYAPAYQLAQPGIESLKKFHHTVEDYPSILDDGSPFHVAYACTPGQPWVTVAWSDSQGQAFRARQYRLRTDAAKPATASEYASIAAVFVDIWHHTMELISVFPIAWHLVVTKVGKRISLDEINAWLRMVALEKGKNKFRISVTSIDLEPAMLVQPPLLAYLQKIAREEHDALQGMTEEQQKEHILERIKPQTPKDEPLATALERPIGDFDDPSEKVFAIKLSKFQIGPSNLADPQPLASAYLVKAPGLNVTQSASSVLLSVFHLDGRCSVDELLQEMRNLATLAHVGGFTYQGGIVPRHIMHAAMMHTSLNGYKP
Length1211
PositionKinase
OrganismProtomyces lactucaedebilis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Taphrinomycetes> Taphrinales> Protomycetaceae> Protomyces.
Aromaticity0.08
Grand average of hydropathy-0.320
Instability index47.77
Isoelectric point5.39
Molecular weight135195.85
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13876
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     565.21|     164|     299|     208|     373|       1
---------------------------------------------------------------------------
  208-  348 (223.03/138.48)	..........................................SKQLEAGDPVY....LAPSGHKATLVEYsfELSSEAYR......L....QLTKLIGFQLLDTSRWVRVHLGDES......FLWPSALTFVPYTALQVKPP........PE.SWFGLKDTWLAQ..CKS.DME....RKVQKQK.EMDANESTD..NLMPDATVEPAVSEQRPASAQ.KPGS
  349-  480 (155.66/90.24)	KDDSHHVYPTPPDATPGPFLKKASH.......................................................dsddedM....HVTD.ADFSFFDRNSPEVIMQEIESinhlptPMETDMRTQAPVSAQPTEPPtasfdmitPA.SQFGATPNIVA...CEA.DKAaasvREVYRRY..........................RQPVPSHfTPMS
  481-  613 (149.08/86.06)	LAQQHNHYGPGGKYYAGS...............sassadnapSSDEEMTDDAYdrerATSSGHVKALLD...DLVSEA...................................................EFDP.......PP........PNiPWH.LVSPRIASnpIKStHLS....LRSQLEKlALPTKEEADliDLVGSLLCGPNIAGFRETSIL.PAAS
  649-  730 (37.44/15.34)	LDDVATIYEDP..KSSNAFKPKNSQrknhpaglashvtllrePRVLLS..RAH....IDEKTHKEIMEDY..EMSTSAIR......LwytaQLSPLDG.............................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.79|      11|      15|     751|     761|       2
---------------------------------------------------------------------------
  751-  761 (19.89/12.42)	FRYLDDLRALY
  769-  779 (19.90/12.43)	FLYEDKVEDSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.61|      12|     299|     851|     865|       3
---------------------------------------------------------------------------
  851-  862 (19.46/15.30)	VALQVVDVDQVC
  868-  879 (20.15/ 6.69)	KALRIKECVALC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.17|      17|      18|     995|    1011|       4
---------------------------------------------------------------------------
  995- 1011 (31.47/19.02)	ISVFPI.AW.HLVVTKVGK
 1013- 1031 (21.70/11.03)	ISLDEInAWlRMVALEKGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     225.86|      69|     750|     127|     200|       6
---------------------------------------------------------------------------
  127-  200 (109.72/71.25)	LQLTYRCAKAGfVPLGPCLLSPLPELTEHSFDenlCLKPLPNG..RYPGPQRQCiMSLHLA...VSGDLTLALAKTDVQ
  880-  953 (116.14/61.42)	LQVYNRCQLTA.TDSDPKLYAPAYQLAQPGIE...SLKKFHHTveDYPSILDDG.SPFHVAyacTPGQPWVTVAWSDSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.90|      13|      26|      59|      72|       7
---------------------------------------------------------------------------
   59-   72 (21.62/17.43)	KRIGQElWHFVLSE
   88-  100 (23.28/13.67)	KEIGQE.QRLDLSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13876 with Med13 domain of Kingdom Fungi
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