<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13865

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGPPVDPQKPTVGEVTRACWARALAPASWEALVRQAATAGAFKQPQLENEVCTALLDLLSEASGSKTASPTTLSYLRHAFGLGAPHAVKSLVQPGILAARLWQRSDASLTTIDSALAVVNAALDAQGASAPTYAATSVEGVLEAVAIASSLLASQLEQSASSSSSIQTPTVDYIIRLLSHPPIRITSKDVDDSAIERCLGNLNSASTSLSTFAPLPTDAAFLGQLQQTIASTRSLLDAKPVERIGAPFNLDEKVTSADPDIAFLIDDLLHRSTTPVGISNTRNAVARIAAALKYRVAEAPSRGGTPESALSATFLEMLLAATSVLRQGEGKRVVESSFAYSRLPDVLSDVFRKISMSDKCQEGLQGGLESAMRAFASAIKTPSSNAMDLDDATSATSPSTIVLNTLITSFCHRELISIDVGASLASPDVHQQDLAPQSLPEGCYNNQLAEQDQEGVRETLNDLPTNYLAQKAIVSGLQAAIHSFAQNLDLVGLSALCKTILDVPDVLEVAFLHLEPREILSPVREFLDQFDTSLENFGDGHPIEGYGKVVLFIETVLSRFKLYADLPRHLGSSKGFFVHWLPSAPAVYPLQGLDEESKLAVDGWVEGLFGEGISDELMHSTNPRVLLRVAPTICKQSLVACQAGVIDLDTLREGLSYFLQELLSFTLPGVVHWLVDEIGRTPPSPAQTTMLDILGVFIFSESLPRLVLELVSSSLAALASKLGNTSPAPTLDLAKLKALVAPYQPVLGASASSTSPASWSTQLTTALPRALATPSSAPPPPSLSAALLHTSPSPSSLLATLLALHQPLLPSASPEPYLRASRLLRLSSALLATPSSTSSTFTFPILQSLITEVLPWRLLELAARGEDEEALAQGELLGEILAAPLLWANEMVVEGGEGVSEQESQVAVLLDGVAWAVRDARRRTEGKKGAAEGEQRRRGAEAFVDRLMAHQVLVDRSAKLAQLRAI
Length966
PositionTail
OrganismLeucosporidium creatinivorum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Leucosporidiales> Leucosporidium.
Aromaticity0.05
Grand average of hydropathy0.098
Instability index48.14
Isoelectric point5.02
Molecular weight102651.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13865
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.76|      17|     136|     248|     271|       1
---------------------------------------------------------------------------
  403-  428 (14.15/18.30)	LNTLITsfCHReLisidvgASLASPD
  798-  815 (23.61/11.77)	LATLLA..LHQpL......LPSASPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.39|      17|      81|     112|     131|       3
---------------------------------------------------------------------------
  115-  131 (28.15/19.38)	ALAVVNAALDAQGASAP
  284-  300 (28.24/11.15)	AVARIAAALKYRVAEAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.77|      11|      14|     469|     479|       4
---------------------------------------------------------------------------
  469-  479 (17.83/ 9.84)	AQKAIVSGLQA
  485-  495 (17.94/ 9.94)	AQNLDLVGLSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.49|      24|     164|      82|     105|       6
---------------------------------------------------------------------------
   82-  105 (43.34/25.00)	LGAPHAVKSLV...QPGI..LAARLWQRS
  244-  272 (33.15/17.49)	IGAPFNLDEKVtsaDPDIafLIDDLLHRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.38|      21|      26|     739|     763|       7
---------------------------------------------------------------------------
  739-  760 (35.85/23.22)	LV....APYQPVLGASASSTSPaSWS
  771-  795 (34.54/11.74)	LAtpssAPPPPSLSAALLHTSP.SPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.58|      25|      25|     849|     873|       8
---------------------------------------------------------------------------
  849-  873 (38.53/23.28)	LITEVLPWRLL...ELAARGEDEEALAQ
  876-  901 (29.40/15.93)	LLGEILAAPLLwanEMVVEG..GEGVSE
  908-  932 (36.65/21.77)	VLLDGVAWAVR...DARRRTEGKKGAAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.28|      35|     144|     429|     463|      10
---------------------------------------------------------------------------
  429-  463 (62.03/40.34)	VHQQDLAPQSL....P.EGCYNNQLAEQ....DQEGVRETLNDL
  578-  608 (46.87/28.54)	VHWLPSAPAVY....PlQG.....LDEE....SKLAVDGWVEGL
  618-  655 (34.39/18.83)	MHSTN..PRVLlrvaP.TICKQSLVACQagviDLDTLREGL...
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13865 with Med5 domain of Kingdom Fungi
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