<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13862

Description Transcription mediator subunit Med12
SequenceMTSRPPLAVSQRQPQRSHSGSGLSQRPAHQRTLSQQYLPPSPVRNDLAPEAGDVVQGRYGSNPRRVGSKLKLELANDGITHAGFSESPLNLDPLSANRVFTPSRIMPLQEASELGDMSPHTSQCHTADNESIPLPMPPRRARFVVPIPRPQTTPAPAPVKKDTRPKPFVLETPTAAPRYSNMGKQEPSGYADYYPWNGDHPEDRFSENIIRNGYFDRAPPQLQTEMASAKAPLFPSLKHKSGLHTLSTLFTGILNQRRHSGQITSTSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGKVLLEQSLKKNVPTDRAVWLAKCVGANEIRAFKRKGVNNTFVIGGEAKWIREWTACVEQFVDTVVSAFGENEWKAKVTYAIRLATHLYAEHLLDRDHYMDWLVSGLENSNQARLPMWILTIRIYWRDLLRSRRTGRRLVTAILGHHTAICQHPDRDILLPLSTQLSSLLESLLLNSPESFVHSFTWAKFRDALLSSLPSDDQAQRHAFESIDKRNERLTRTHIKSQPAVRGILVKLLDTTLRTPFKDDLASQLWKVSEHKHSLIRTVLEWSISPYRPGIAKVYVTASILRFFSVQGADITGAVLDFLDTDPLRETDRKHLVYHLVSELVRTDDFSVPRYLQWLIARGGLANAVETSPDGPCPTRLLVEVPIHALSESIRSLRATILRRSSFSVEYEAEDMATAIRCIKYALSVPLELDDPLLLKKPMSISKLAHRIERSSRALQTEVGSWLYNGYIGGIVRSLSSEKSGVDDSNIEFDSVRALLEAAQDYTMLENVLKALAVSSNAELLASCADTVNLHIQVFAATGSAKSLFQTLLERLKAIREQQGIGARPLLASLASLAPRICGLEEVATQLQKDLIRTDRTSAVDASSPLSDTMATQLQDDETELHEQIEKLASYTSADRPTMERLFQAITFHRLQTCWGKPDERQRAYCILLTRLRVFDTGYFDTLMRLWVQHIRKLTHRPPVAQIFPLLMSSGCLSLAVLFATASRTPMQTAQGQPNPAMSASIYMQEILQMLMMPLSPTQIMASEDCYRFRIIQEQARLENVREVMPLIRGALAEYSSSRNQITQPLDDEKTRTQFLELLRSLILVDSNAAGQTLSPKSPDPKLANLIESVTTRLLTSRDGGGQKTFEQVLELANEFTLPFCQVKLSLNLAVSESTGPDHTERLQSQLIQLSKAMDNAIDANNIMWTGMLPCLSPEITQHMRNRAEARFLYLIPSLKCAVTSEEVFEKDIHMAENLLAVIDSIIRGALTPKSSQISNAMVDKLVDLWEILATTNDEAVPLKTATLSHWLPLLLSYLTLNASTATATTSKPANDTRARALLTLAGLTQELDHAPSSDLSQRAFDLALVLVDHLADDARLQCVRAVKDVTADPRLRYLFSFAPNPAENLMLAHREKPPPGLGPNERRALALGLGTGMLPERLTPLVMRRWEILNEPTPNVGENDTSLSLHLFEARKI
Length1491
PositionKinase
OrganismPseudomassariella vexata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Pseudomassariaceae> Pseudomassariella.
Aromaticity0.06
Grand average of hydropathy-0.266
Instability index45.32
Isoelectric point8.68
Molecular weight166699.10
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13862
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     319.11|     116|     225|     830|     954|       1
---------------------------------------------------------------------------
  830-  918 (127.67/73.88)	.......................................................................................................QVFAA.............TGSAKS.LF.QTLLE...........................RL.KAIREQQGIGARPLLAS..LASLAPRI....................C.GL..EEV...ATQ...LQKDLIRT.D...RTSAVDASSPLS.D.TMATQLQDDETEL
  925-  951 ( 6.97/ 8.75)	LASYTSADRPTMERLFQAITFHRLQTC.....................................................................................................................................................................................................................................................
 1028- 1151 (76.34/40.03)	...........................wgkpderqraycilltrlrvfdtgyfdtlmrlwvqhirklthrppvaqifpllmssgclslavlfatasrtpmqtaQGQPN.............PAMSAS.IYmQEILQmlmmplsptqimasedcyrfriiqeqaRL.ENVREVMPL.IRGALAE..YSSSRNQI....................TqPLddEKT...RTQfleLLRSLILV.D...SNAAGQTLSPKSpDpKLANLIESVTTRL
 1152- 1301 (108.13/59.15)	LTSRDGGGQKTFEQVLELANEFTLPFC.................................................................................qvklslnlavsesTGPDHTeRL.QSQLI...........................QLsKAM..DNAIDANNIMWTgmLPCLSPEItqhmrnraearflylipslkC.AVtsEEVfekDIH...MAENLLAViDsiiRGALTPKSSQIS.N.AMVDKLVD.....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.71|      18|      21|     135|     154|       2
---------------------------------------------------------------------------
  135-  154 (31.16/24.55)	PMPPRRArfVVPIPRPQTTP
  156-  173 (33.55/19.10)	PAPVKKD..TRPKPFVLETP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.89|      13|      22|    1346|    1358|       3
---------------------------------------------------------------------------
 1346- 1358 (22.44/12.06)	PANDTRARAL.LTL
 1369- 1382 (19.45/ 9.39)	PSSDLSQRAFdLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.30|       9|      23|     354|     366|       4
---------------------------------------------------------------------------
  354-  366 (14.02/23.08)	GEakwiREWTACV
  378-  386 (18.28/11.93)	GE....NEWKAKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      16|      23|     687|     708|       5
---------------------------------------------------------------------------
  687-  708 (20.39/22.62)	IRSLratilrRSSFSVEYEAED
  713-  728 (28.21/15.64)	IRCI......KYALSVPLELDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.51|      52|     240|     298|     351|       7
---------------------------------------------------------------------------
  298-  351 (83.67/57.44)	RLSRT.I..PHGIRG...KvLLEQSLKKNVPTDRA..VW........LAKCVGANEIRAFkRKGVNNTFV
  526-  593 (66.84/38.01)	RLTRThIksQPAVRGilvK.LLDTTLRTPFKDDLAsqLWkvsehkhsLIRTVLEWSISPY.RPGIAKVYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.44|      20|     240|     406|     428|       8
---------------------------------------------------------------------------
  406-  428 (34.33/24.47)	HYMDWLVSgleNSNQARLPMWIL
  433-  452 (35.11/17.70)	YWRDLLRS...RRTGRRLVTAIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.76|      20|    1093|     216|     236|       9
---------------------------------------------------------------------------
  216-  236 (32.74/20.09)	DRAPPqLQTEMASAKAPLFPS
 1311- 1330 (36.02/18.03)	DEAVP.LKTATLSHWLPLLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.59|      34|     240|      15|      51|      10
---------------------------------------------------------------------------
   15-   51 (57.46/41.94)	QRSHSGSGLSQ...RPAHQRTLSQqylPPSPV.RNDLAPEA
  256-  293 (51.13/29.16)	QRRHSGQITSTstfKPPPRVTLTD...TKREVwLKDLANPA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13862 with Med12 domain of Kingdom Fungi
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