<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13853

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAAEYQTNALVVNNISFIGYAFYEPVSPPATFFGPGALELESALKNDGCLAYVDGTRRGLWCFRVWRKDGAPGTQPETSGFAKSVQKSGYTLSLAEEGAYEPAALAKTRGFGPNAANTPSSSSSSGSAILDLNFRNPSSATAPSTQPTLGLSVEQEPKLGTSNDAANSAPTSIRDTHGHFISAVLSALSTAFCAKTGATPMNPRTMLLPKVMEDEGSANAPILASLRAYLTTTGVLVAEISLSTVEGLDTLSDYATLPSIGITVLAAPLGVFATCQIPADSERSSVESAVGQSPDTQTLRLRSERDERSHPWRSICTKLLEARNGSCPVSGSQKWLNLQQIRRKPTEPKFDGKRTPLPHASPNISWPSSLCFCKALSKLSLKGGAEEPPPSEPHKSYDPLTLAKTWFLGSDKRDEEMAKKRQEREAAAARETALSDGQIQNTAGLSPLALQRLGNTGPPAGAMYPTPPDGVQIPVGVTPSMDGTVSSPGNNPSAMAMVDIDTVITIPGDTYHDGWENTGVKRERATGSFESENLFGDLGPDMFGDNDITDADFNFFDEQPDGMELTLDLQDMTGADTNLNLHPNLDAPAATELKVESPQPPPHIVPLSPVFAKPELKHARSSLTEDARRPVETQPDQHQQSSGTKRQASPFNPDTVFKRIRASLDNRKAFQQNSQIQISQPGSIFDKVDFGPSLSVVNSKYQGNGRFDVSFSQGPGPSTFNAPPTTEYLRRHNRGRKGLKEPPANISEIFVRMVNGQGSTSQHPSPTKLDDPPSDADEISLVSDLDDSSYESDEPLSPAKPTSVRRRRGDDDGESLATSFKELECLDAASPQLSLDLPRFSKSEVELSLAKYFADPEPPSFEVSLADQDFVMAAQILMEQASTSTLHLTNEAHRSLQTQLDRRRDLLSITNQSVQDLKSMLPTCFGEPVDSQFRPFMEIQDIPLLGQPTRMQPRPPGVDQLKPNNLFQIPSPHFELRRYESKLSVLPSAISFWESLGLGPSNGNKDINAICIYPDFAGLKDDVDCFLDRMQSIYESLKLGSFSRLTESVKIPGGLLPYQVDNPSETLQSIPSILGSAQLAGLSKLSDELFQLTAKETNFVVFFLYPADTPGAVVESCYSFHQLFERYKKLVAASRRPAENEMALQLVPIDFIASASSLATPSPVDFIRLAIETYDRCTFFGGPVPSPAIVLEKPLPRMIDFKLSASPSASLLHENTCLHIAYAQSIDERWVTAAWTDNRGSKQMTASYCLGRKGKSIATPLADVAHEIWQTTRDLISVWKVHWRIIITKCGVMEQSEIELWSILAQSDPKSITLTLLTVDTDPSLQLIPPAVKVPYNALGALYTTPVSTPQASMVSPEQSGNPPTPSLRDTATSAPTPGGGDSAVAPESDADATLVDVTDQTWGAVLSHRLNNSNSLTELNPAIASGYLVKRSGTRVEDPPVVMEVNIVHSEGNPRAYETLLREMLTYFRGLGTLARARGMVEKEVDVRPWHIAAAEKGVRALYLLM
Length1508
PositionKinase
OrganismPseudomassariella vexata
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Xylariomycetidae> Xylariales> Pseudomassariaceae> Pseudomassariella.
Aromaticity0.07
Grand average of hydropathy-0.356
Instability index49.46
Isoelectric point5.12
Molecular weight163711.20
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13853
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.19|      50|      75|    1064|    1116|       1
---------------------------------------------------------------------------
 1064- 1116 (77.69/64.00)	PSE...TLQSIP.SILGSA.QLAGLSKLsdELFQLtAKET.NFVVFFLYPADTPGAVVE
 1138- 1193 (71.50/47.62)	PAEnemALQLVPiDFIASAsSLATPSPV..DFIRL.AIETyDRCTFFGGPVPSPAIVLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.92|      31|      76|      24|      55|       2
---------------------------------------------------------------------------
   24-   55 (53.83/38.29)	YEPVSPPATF.FGPGALELESALKNDGClAYVD
  101-  132 (50.10/30.67)	YEPAALAKTRgFGPNAANTPSSSSSSGS.AILD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.19|      52|      77|     332|     393|       3
---------------------------------------------------------------------------
  332-  393 (80.04/59.59)	GSQKWLNLQQIRRKPTEPKfDGKRTPLPHAS.PNISwpsslcfckALSKLSLKGGAEEPPPSE
  410-  462 (75.15/35.94)	GSDKRDEEMAKKRQEREAA.AARETALSDGQiQNTA.........GLSPLALQRLGNTGPPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.77|      26|      27|     530|     555|       4
---------------------------------------------------------------------------
  509-  536 (39.82/28.25)	GDTYHDGWENTGVkrERATGSFESENLF
  537-  562 (48.95/36.85)	GDLGPDMFGDNDI..TDADFNFFDEQPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.00|      11|      27|     740|     750|       5
---------------------------------------------------------------------------
  740-  750 (20.31/11.40)	LKEPPANISEI
  770-  780 (20.69/11.80)	LDDPPSDADEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.62|      76|     747|     200|     289|       9
---------------------------------------------------------------------------
  146-  248 (104.11/63.73)	TQPTLGLSVEQEPkLG...TSNDAANSAPTSIRDthghfisavlsalstafcaktgaTPMNPRTMLLPKVmeDEGSAN......APILaSLRAYLTTTGVLVAEISLSTVEG
  257-  300 (40.10/33.16)	TLPSIGITVLAAP.LGvfaTCQIPADSERSSVES......................aVGQSPDTQTL.............................................
  950-  998 (57.41/25.95)	.........................................................TRMQPRP...PGV..DQLKPNnlfqipSPHF.ELRRYESKLSVLPSAISFWESLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.81|      16|      18|     610|     626|      10
---------------------------------------------------------------------------
  610-  626 (24.36/19.46)	PVFAKPElKHARSSLTE
  631-  646 (30.44/19.60)	PVETQPD.QHQQSSGTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.98|      22|     204|     695|     721|      11
---------------------------------------------------------------------------
  664-  686 (36.96/15.87)	SLDNRKaFQQNSQ..IQISQ.PG.SIF
  696-  721 (28.02/27.33)	SVVNSK.YQGNGRfdVSFSQgPGpSTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.18|      38|     900|     463|     508|      14
---------------------------------------------------------------------------
  463-  508 (59.78/42.90)	AMYPTPPDGVQIPVgVTPSMDGtvsspgnNPSAMAMVDIDTVITIP
 1342- 1379 (69.40/32.97)	ALYTTPVSTPQASM.VSPEQSG.......NPPTPSLRDTATSAPTP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13853 with Med13 domain of Kingdom Fungi
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