<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13848
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSSSASALGLSNDELKVVEQSRQRLYQLTNSIGGLRSKVLQSNPLPPLQELQNQADVLQNNIASVLQVLSKNHDLFTRLAVHPSTNYPGRIQEGLLMGLLRKKPEPEVEAAMNEGRKTYGDMADGEGFEALSGRWGKVRNYMIDRLEPFMKEEQLDPYTTEEREMGVENVRTGLRRELEEFESDSEEDDEDEDEEEGGNNKGRNVSQAADDDDPDIIMLDRPPPPLPMEGTGWLAGCFLARVAKT |
Length | 245 |
Position | Head |
Organism | Pseudomassariella vexata |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Xylariomycetidae> Xylariales> Pseudomassariaceae> Pseudomassariella.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.776 |
Instability index | 60.49 |
Isoelectric point | 4.52 |
Molecular weight | 27420.18 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP13848
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.11| 17| 21| 36| 56| 2
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40- 56 (30.65/30.39) LQSNPLPPLQELQNQAD
58- 74 (28.46/15.81) LQNNIASVLQVLSKNHD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 63.56| 19| 21| 173| 191| 3
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173- 191 (30.77/17.91) GLRRELEEFESDSEEDDED
197- 215 (32.79/19.52) GGNNKGRNVSQAADDDDPD
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