<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13846

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGESKVINNLNKNPFQNDFDLFSKKNEANLIPLKLIYERVIQNYYSELKNLSETLPTKTNSQKKVEIFKLAQNLNQCAIKLLVLIRWAKQSKDVLRCKSICNFLAAQNSYFREAADALHMVHQEMNLTRIPTFDIPTAVDVLTTGTYSHLPSMIKEPMDLSSLKNEEIKDAIEKLEDVTRLRLLCDEIIPKPMKKIINEFEVTLKLEGKQQNQWKLLDLKIFVQPDDELNQGYIIQDIQISNLKTNAQNTLKIDTSKTDLSSNSIKNTSTPNVITNINNNTKTLTNSKEEEKSSKKIWPLIELYRCLHSYCLSMQLEILLFQIGYLIKTKWANRLKFNISKDKKTLQLFYWIENESGRSKDTKNKEVKKSNILELSITSTEDKIMFCTNKEDKEEGTTISTSSTTNTQTNTNAQMNINTNTNTNTDNNGLLITKSQSQIFEYEKYIQNDLTIQCYQLLPDGTKKELIDPSTSSKVKIIINPRKLNIEKILDYVTEVHAFAILFELRNILIGKSNSKIAIHKCNSNDIRERNFFPYKTNGNKKDKPQPELIVCYRINHYVRITVDRRTGRIVINEYNEQGTNNANNFIQEKIKIVEEQINKDMFNAVDYLMNLRNLTIINEIEILSIYLGLEPSKKLLIQQEELKRLMNSNELFLSQSIIYLKYPNYPNYYIIIYIDNEEINSSTRHKHDVSYFKVWLVCTQKKNSSGFLGFTLIMNLDISQLLENDNTENDSDDEYDDFHHLRKRRCIEEPSVWDKTKNLILDQETLSRIEAVCRYKIAYCLLTTQLKDLHIPYYFVSFKSNNHVIDYDSPLSVFDLVIKIRVKDIIPDVVRKCVLGDYILKLNNDLYITATGNTLAREPPMMIPFEKISNRNQVKGMARGIEVVAKLQVKSGELPINEDFSIGDINFSVKTKVLTFTYSKINDCIRKILNIWKGLVMLRIIASQAYTNRDILENHGIYIDKINLLKTKILFYEKNFVEFALNSSLDNVSTNGINIIFGVKGDNKATVFYKEKQFLIEDFLKDYNVINFLLKLKTKFKLFKNINSIIRSREIFNTYSPLIVNKESLEKIKLIYNNQYTIEIGQCTDNLVGILYSAQSKINIIPQFQLFIEFVSQLHATNAPPKKINIGERENKENKEKENIKKESEKIEKMENDRMKEEEQGDCICLKIPNGIIFDIKYIDQVMDGLNKLMNSVSYMDWLYYTINQIEATKTNKGTVNYSKTAKEPLLLNYIGESLELTLSYNFNEDKWLLQLKSNDESINGDKLIEKILKLKNPIMGLKNLTQLMVLPPAIAKEILILINSEKKVNQHNVTSEICLTVPEGLPHYLPNAGESSIYTDFENKRIGLFCQFSFNDPSTNGQSNEASQTKHTIVIPFFYNWESRFFCEWNANPELSKLKTNNDCKSWLQSDPNRKLSKLNVLLIQITIVMEKKKVKEAIRFAFSTLSSMPPEKFKAIEDKNS
Length1461
PositionTail
OrganismNeocallimastix californiae
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Neocallimastix.
Aromaticity0.09
Grand average of hydropathy-0.419
Instability index35.22
Isoelectric point8.59
Molecular weight169386.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13846
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     216.00|      79|      91|     828|     918|       1
---------------------------------------------------------------------------
  801-  847 (33.52/27.38)	..............................................KSNNHVID...YDSPLSVFD..LVIKIRVKDI....IPDVVRKcvlgdyILKLNND
  848-  936 (118.39/90.61)	LYITATGNTLARE..PPMMIPFEKIsnrNQVKgmaRGIEVVAKLQVKSGELPIN...EDFSIGDIN..FSVKTKVLTFtyskINDCIRK......ILNIWKG
  940- 1002 (64.09/35.22)	LRIIASQAYTNRDilENHGIYIDKI...NLLK...TKILFYEKNFV...EFALNsslDNVSTNGINiiFGVK..............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     344.81|     106|     124|    1045|    1157|       2
---------------------------------------------------------------------------
  442-  499 (39.61/15.45)	..........................EYEKYIQND.LTIQCYQllpdgTKKELID.PSTSSKVKIIINPRklnIEKILDYVTE.VHA...........................................
 1045- 1157 (163.55/114.53)	NSIIRS.REIFNTYSPLivNK..ESLEKIKLIYNNqYTIEIGQ.....CTDNLVG.ILYSAQSKINIIPQ...FQLFIEFVSQ.LHATnappKKINIGER....ENKENKEKENIKKESEKIEKMENDRM
 1172- 1278 (141.65/82.31)	NGIIFDiKYIDQVMDGL..NKlmNSVSYMDWLY...YTINQIE.....ATKTNKGtVNYSKTAK...EP......LLLNYIGEsLELT....LSYNFNEDkwllQLKSNDESINGDKLIEKILKLKNPIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.33|      35|      74|     267|     301|       3
---------------------------------------------------------------------------
  267-  301 (60.92/34.31)	KNTST.PNVITNINNNTKTL...............T..NSKEEEKSSKKIWPL
  329-  376 (41.05/20.46)	KTKWA.NRLKFNISKDKKTLqlfywienesgrskdT..KNKEVKKS..NILEL
  406-  441 (40.36/19.98)	TNTQTnTNAQMNINTNTNTN...............TdnNGLLITKSQSQIF..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13846 with Med14 domain of Kingdom Fungi
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