<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13826

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRRDWLGHQPAKSSTTVPGHWLLDLPRSSDGIQVRRFRSVAESSQAGPSSDTATILQRLREDTLEKTWRLVNERGSHSDIRGALSTGCAVICVEDGERILWSFSAGTHMNEDENYSALQELEGLQEVLPRLSPIEPAKLVKCSKHGHSVSCLASPRPDGIAGPIPQPCDIRWTNSDVVKRSWEKLGHAIVEKLAWNNGQRIWMGDHDHFWSPAKATLLPMASPSLLLRIEQQPVPRCRAVPSDKKPSLHQLPFILFPLSAPALCLGPQDLSKVQIARQSALFDKSLGLGWKHGRAERRTAAQLAEESWSDWSVYWIPTSPFRISEIADTTAAQLAQTWQEGKGVVTIWPTHLAHDLSAAPLSASHKRNPVPIIDLPTPSGAMDVAVDVFELMANYREPAVEENTPGAEEIVISDGDNDGPAHRSFFDRPPQSSLTSRANGDSDLDDLFSTHSSSPEANEPIAIESDQASEDDLFGEPEEDAAVPDLKVEEERTGLADDDDPPPGLVMADDFDGLFDDDELEDSKVTEDDFDFFDSPAAEKNSLPTITEEVVPDDMVPQKVTTPPSSPPVQPDLVDLLEGQPPPPTDSEGPIAAEDPPNPQAVHASPIEIVVDDTPVIATHQTPLHTSSDRPGKRKRPVFEADIVPSDFEALPLHSASTSLASQIYALPSPAPTPESIRPDLVERLKLPSQPGAFDYAKDWIMEADQSETEEEEWSGAPPTPESEVDDTESTSGRPTPAVPADARRGGEVEYGSIVCVGPELAILVEDEAGRAAVERPWPLNKMTPESPVSLVGPSPMIDAEHIDLDRLCLEIIYNSQFRQSLLTSQIRSGSIDVESLGSLITSGDVLNDVASLPDTHLLDPDDKFGVGPLATCKVHAGYHGNVMQLDISGLHYWQEIGLQPVGGRKDLQILVVSTNASAKVYAMEFLERMHEIYGRLRLGSMVPSQETPGAFISASEKDLPEVLTKAVTSAKENTVVFVLSDLPVKSMSTTRTLKAARETVITHYLTLSDIEPSRLENTAFDVFNRMPRLLQQKDVHISSDSNRSYMQYPSFTIAPDHPPRPALTLAWPLRSYDVFNKWRLVHGGYIVTLDTMIAFVIDAEGENFQVKSWKVREKGWKQRLEVLWVFLAGFARVAAVEWRLSISALGGMTDEEQEAWSSLLASKKAPVTVLVAEVSLEHENPADRSRVLATNVPVALLADPSSTLIDETLIGHALPCHHRIPLGSSSTYPRTTFILSLATPRGANNTALYHVLHHRPAPGKEDEEVDKLFAREFYRLACLARVRFRMNDGCLPVHLESIRLISAALDIVTTSESP
Length1315
PositionKinase
OrganismNaematelia encephala
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Naemateliaceae> Naematelia.
Aromaticity0.06
Grand average of hydropathy-0.336
Instability index55.48
Isoelectric point4.81
Molecular weight144438.58
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13826
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     448.85|     103|     105|     477|     581|       1
---------------------------------------------------------------------------
  351-  493 (98.59/45.01)	HLAHDlsaaplsashkrnpvpiiDLPTPSGAM................D.........VAVDVF...ELmanYREPAVEENT.P......GAEEIVIS.DgdndgpahrsffDRPPQS.SLT..SRANGDSDLDDLFS..THSsspeanepiaiesdqaseddlfgePE.........EDAAVPDLKVEEERT
  494-  607 (162.43/84.12)	GLADD..................DDPPPGLVMADDFDGlfDDDELEDSK.........VTEDDF...DF...FDSPAAEKNSLP......TITEEVVP.D............DMVPQK.VTTPPSSPPVQPDLVDLLE..GQP.......................pPPtdsegpiaaEDPPNPQ.AVHASPI
  608-  727 (91.66/41.28)	EIVVD..................DTP....VIAT......HQTPLHTSSdrpgkrkrpVFEADIvpsDF...........EALPlhsastSLASQIY................ALPSP.APTPES...IRPDLVERLKlpSQP.....gafdyakdwimeadqseteEE.........EWSGAPPTPESEVDD
  728-  805 (96.16/43.70)	TESTS..................GRPTPA.VPADARRG....GEVEYGS.........IVCVGP...EL.....AILVEDEAGR......AAVERPWPlN............KMTPESpVSLVGPSPMIDAEHIDL.........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.15|      11|      29|     299|     310|       2
---------------------------------------------------------------------------
  299-  310 (16.66/14.60)	TAAQLAeESWSD
  330-  340 (21.49/13.41)	TAAQLA.QTWQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.52|       9|      51|    1021|    1030|       3
---------------------------------------------------------------------------
 1021- 1030 (14.42/10.36)	FDVFNRMpRL
 1073- 1081 (20.10/ 9.06)	YDVFNKW.RL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     333.74|      92|     107|      91|     188|       5
---------------------------------------------------------------------------
   28-   78 (39.22/14.27)	....................................................SSDGIQVRRFRSVAESSQAGPSS.DTATIlQRLREDTLEKT....WrlvnERGSHS
   91-  188 (146.43/96.55)	ICVEDGERiLWSFSAGTHMNEdENYSALQELEglQEVLPRLSPIEPAKlvKCSKHGHSVSCLASPRPDGIAGPIP.QPCDI.RWTNSDVVKRS....W....EKLGHA
  201-  295 (148.09/80.40)	IWMGDHDH.FWSPAKATLLPM.ASPSLLLRIE..QQPVPRCRAVPSDK..KPSLHQLPFILFPLSAPALCLGPQDlSKVQI.A.RQSALFDKSlglgW.....KHGRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.02|      28|      30|     896|     925|       6
---------------------------------------------------------------------------
  847-  879 (31.53/17.28)	...LNDVASLPDTHLLdpddkfGVGPLA.TCKVHAGY
  896-  925 (39.84/31.89)	EigLQPVGGRKDLQIL......VVSTNA.SAKVYAME
  929-  957 (38.65/23.79)	R..MHEIYGRLRLGSM......VPSQETpGAFISASE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.32|      26|      26|     959|     984|       7
---------------------------------------------------------------------------
  959-  984 (40.87/32.97)	DLPEVLTKAVTSAKENTVV..FVLSDL.P
  985- 1013 (31.45/23.31)	VKSMSTTRTLKAARETVIThyLTLSDIeP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.82|      12|      35|    1207|    1220|       8
---------------------------------------------------------------------------
 1207- 1220 (18.25/19.90)	DETLIGHALpcHHR
 1245- 1256 (23.57/14.85)	NNTALYHVL..HHR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13826 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YAKDWIMEADQSETEEEEWSGAPPTPESEVDDTESTSGRPTPAVPADARR
2) YREPAVEENTPGAEEIVISDGDNDGPAHRSFFDRPPQSSLTSRANGDSDLDDLFSTHSSSPEANEPIAIESDQASEDDLFGEPEEDAAVPDLKVEEERTGLADDDDPPPGLVMADDFDGLFDDDELEDSKVTEDDFDFFDSPAAEKNSLPTITEEVVPDDMVPQKVTTPPSSPPVQPDLVDLLEGQPPPPTDSEGPIAAEDPPNPQAVHASPIEIVVDDTPVIATHQTPLHTSSDRPGKRKRPVFEADIVPSDFEALPLHS
696
395
745
655










Molecular Recognition Features






MoRF SequenceStartStop




1) KRKRPVF
2) LVMADDFDGLFDDDELEDSKVTEDDFDFFDS
3) RRDWL
4) YAKDWI
633
505
2
696
639
535
6
701