<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13821

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSSSSRPANGSQPSGSTTTAAPRPLNPQLGSEPWFAYPTPTPEDLRSELPPYLEDVENVRLGLVLDRLVRKSYGDLRVLLQQTLPATLETHHKPKQIINYAKQTRQAVLKYLAIIRWKNAVDIHISGGPPISHQNNGPAASFPTPQTNGESNDTSPAGVGYVGKGKGRMVDDEPKVNVARGKVTDAKRITHFMEHQNRQHELAIEHLRHTTKGIESLRFRNADLLTAISLLTLGTYPRLPTNLTEPFTPRKPLTNASVLRTLRQLDSHILYRLRCIEYLPPELEVYRIADGRAYVRGGGPGGWKAELTVVGFDDGEDSRWWLTGVEWGWKLKKRGTDDPGGTTGKRFEGEQLQGILDVANVDVLPPRPVQTEVNVVVTDTDAGGKETPGQGTVRTIAERRKRLVDAPLVRIYNFLQQLSLSYQLEMLFSEALALSQGRWRGQLLVQMDRDKKELKLKYWIRPRPPPVQQQTQAAVGKRPAPPVASSSSRTPLTGGTLTVSLSEATEPLSDRGSLTAEISADGRISSERILRLGIVVKWEVGEAGVGGGLKTGDALDSSELKIDSNALSIENILNLASRTHASLLTRHHTAALLAAPRIALFPADPPQLVETDNTTRPLALRIPLPSRQRQAHLLIGVSSLTGLIEIEDSGSTDSSATSPEDRGGRAKLATVSANERGRLMEDVGRLLVAVITENLEAQFRQLGCHPARRIPLRSQDMAKNELHPASTVFVPLPTSELHHLTARVAGQGVAFELVKLVRSPSEAGLGMKLAIGDRSPVDLVRLRARRKDRKGANPGKRAREADQLVVETSVNNVSPPDWQIDDRDLRDVFIFANALVAQTIVEQQLKDRSIPYSLHYPPASGSGSPRSSSAVAGMVPTLLVDAGDLLKDGRAADVAMPRVYMQIREWWKGDKCSVVTVIHLQHKPALSSSGASPATSAPLSTAAMSEGITFDQTSSIVRFSAPDISRCVPSLLEQWERLCKVIVVAGEVNKLNKADAFKGLRMLSFDLRTATMMYSPGFCASITYNPSSDSYEVSFFRSGFSSGTTPGIQAIATPAISIDGTADASPHQFIAPLLGNRLNEMTVQGRRGSVAREWIALLRWTLPFLLEVESIRSASSTAEFPALVVRGVSEFKLIWDVEGVRRYGLDWKLVRNGRWIVKDACLSDDQSCGIITPIPGWKERVVEDAFQRLKSTDRDKDKTDGQGSGDGTTTTTGTSVLAVKVDGGAGLMCDGKIVGDIVRGVCADVENILGMS
Length1252
PositionTail
OrganismNaematelia encephala
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Naemateliaceae> Naematelia.
Aromaticity0.06
Grand average of hydropathy-0.298
Instability index47.18
Isoelectric point9.01
Molecular weight136518.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13821
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.18|      22|      23|     282|     304|       1
---------------------------------------------------------------------------
  282-  304 (38.62/24.63)	ELEVYRIADG...RAYVRgGGPGGWK
  306-  330 (41.57/22.03)	ELTVVGFDDGedsRWWLT.GVEWGWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.04|      12|      15|     491|     502|       2
---------------------------------------------------------------------------
  491-  502 (21.27/11.20)	PLTG.GTLTVSLS
  507-  519 (16.76/ 7.28)	PLSDrGSLTAEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.40|      19|      23|       7|      29|       3
---------------------------------------------------------------------------
   10-   28 (34.92/17.86)	GSQPSGSTTTAAPRPLNPQ
   30-   48 (37.48/15.95)	GSEPWFAYPTPTPEDLRSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.63|      17|      23|     740|     756|       5
---------------------------------------------------------------------------
  740-  756 (27.14/17.36)	LTARVA.GQGVAFELVKL
  765-  782 (24.49/14.83)	LGMKLAiGDRSPVDLVRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.39|      18|      19|     149|     166|       7
---------------------------------------------------------------------------
  134-  151 (29.56/16.36)	QNNGPAASFPTPQTNGES
  152-  169 (31.83/18.22)	NDTSPAGVGYVGKGKGRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.25|      13|      19|     705|     717|       8
---------------------------------------------------------------------------
  705-  717 (25.12/14.50)	HPARR..IPLRSQDM
  723-  737 (19.13/ 9.19)	HPASTvfVPLPTSEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.01|      12|      19|    1013|    1026|       9
---------------------------------------------------------------------------
 1013- 1026 (19.96/18.32)	MYSPGFCASITynP
 1035- 1046 (23.05/12.78)	FFRSGFSSGTT..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.18|      17|      23|     583|     600|      10
---------------------------------------------------------------------------
  583-  600 (23.15/16.03)	LLTRHHTAALLAApRIAL
  608-  624 (29.03/15.16)	LVETDNTTRPLAL.RIPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.70|      14|      18|      81|      98|      11
---------------------------------------------------------------------------
   81-   98 (19.29/26.40)	QQTLPATLethhKPKQII
  102-  115 (23.41/16.17)	KQTRQAVL....KYLAII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.96|      11|      18|     664|     674|      12
---------------------------------------------------------------------------
  664-  674 (17.47/11.47)	GRAKLATVSAN
  684-  694 (17.50/11.50)	GRLLVAVITEN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13821 with Med14 domain of Kingdom Fungi
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