<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13818

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDERCQPDFLRRVQLGEVVVLHDYQVDQRMTVADIGCAEIVNAAYRRGVPAKKFVKLLSKLENESNPVDVADQLASSLLDQLLQPPGTPAIVLSYLSQSLSDSTGPAILPAQTFLVHLLFRLALPPPPSTSALAAIASLLLACPSSLFSPLSGELHCPASLVPDVGSSTSTSPTPTLGLVLPLLRLCSTSAPAPIVSLTARILGLVQPYPAPPLDVGLEAGGLLQTLPEMVSTPLRDSLGGLMADLAISQDTTGMGLSLDGMTGMENVIPNQGDITMHGGDENAQTVTLPPLGTDISSLPLPQSLAFLLNYLRRSSRWTDNADSSGDQVLLRLAPHLAPDPTTFLAQLLEASIVAFSGQADGDSPGGIEKWLFISEGLPSLLQSWKGHGDLGYPYPDTLATSLKSVFERQSGRLAENNTWMAQRYDALVSAVDSEDETGGYVAPDGWSLCSLEVTLLLRLIELDLLSRQDARSVLPGVTIPSSSSGESLSNRVAVASPSHLPPLAHLIIYSPGAARSFASEVSETIQSLTTNPPPDNLFSNLSASPSLIACLAAASPPAVLLGLLEKNLLDRPDDVNLRADDPQGTMTRFGEGVMLVEAAVHTFDLPLPRLLVEGRRALSLGDWEQTQRGLLNGWIKALFGSDGIDDQILSATSLQDFYRLAPSLIQQAIAARAAGQIDIDTLYSGLSYFSQDLLSWSLGGIVAWLCEETVRNGPVSGLHLQVLQRLVLGDAFPEALLRVAGGAIAGLLAPSSGLHEVFAASGIDVAAVRLKLEAIGVDVNQAPPLSFAQRIANLRVTLQTVRQPELSQSSWTDALLPAFNSCLVSIGDLEALQLVLSEILFPSSINNESGDPLGRLFAILTVLGLGRAHSPLLSVLLDVTIPNVFEYNSPLAIAQPQSQPYAALGLAKLIKHSLLMATSLQIDTGGLVHAFADDLEYQSSRPVRDMLDRQRGKKAKRARRGVAREIGQAQKAVLEMVVHALGADEELRGTWPVFERFT
Length999
PositionTail
OrganismNaematelia encephala
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Naemateliaceae> Naematelia.
Aromaticity0.05
Grand average of hydropathy0.146
Instability index49.91
Isoelectric point4.79
Molecular weight106441.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13818
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     471.47|     100|     106|     162|     266|       1
---------------------------------------------------------------------------
   85-  161 (67.99/18.71)	...........PPG.TPAIVLSYLsqSLS...........DSTGPAilPAQTFLVHLL.FRLALPPPPSTSALAAiASLLLA...CPSSLFSPLSGELhcpASL...................
  162-  261 (159.37/56.97)	VPDVGSSTSTSPTP.TLGLVLPLL..RLC...........STSAPA..PIVSLTARILGLVQPYPAPPLDVGLEA.GGLLQT...LPEMVSTPLRDSL...GGLMADLAISQDTTGMGLSLDG
  289-  387 (152.17/48.37)	LPPLGTDISSLPLPqSLAFLLNYL..RRS...........SRWTDN..ADSSGDQVLLRLA.PHLAPDPTTFL.A.QLLEAS...IVAFSGQADGDSP...GGIEKWLFISEGLPSLLQSWKG
  773-  863 (91.94/27.57)	LEAIGVDVNQAPPL.SFAQRIANL..RVTlqtvrqpelsqSSWTDA..LLPAFNSCLVSIG........D..LEA.LQLVLSeilFPSSINNESGDPL...GRLFAILTV.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     422.29|     109|     116|     536|     646|       2
---------------------------------------------------------------------------
  435-  533 (113.92/66.85)	EDETGGYVAPDGWS.LC...SLEVTLLLRLIELDLLSRQDA...RSVLPGVTIPSSSSGESLsnrVAVASPSHLPPLAHLIIysPGaARSFASEV.SETIQSLTTNP......................
  536-  646 (178.41/115.24)	DNLFSNLSASPSLI.ACLAAASPPAVLLGLLEKNLLDRPDDvnLRADDPQGTMTRFGEGVML...VEAAVHTFDLPLPRLLV..EG.RRALSLGD.WEQTQRGLLNGWIKAL..........FGSDGID
  657-  765 (129.96/77.52)	D..FYRL..APSLIqQAIAARAAGQIDIDTLYSGLSYFSQD..LLSWSLGGIVAW......L...CEETVR..NGPVSGLHL..QV.LQRLVLGDaFPEALLRVAGGAIAGLlapssglhevFAASGID
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13818 with Med5 domain of Kingdom Fungi
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