<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13815

Description Uncharacterized protein
SequenceMPPTSRYPSSSQSFVGSATANLASGKGNGTKSRHPLPSRPGTNASTASDKGKAKEEVEIESFDPPAWRTVLNQRADLGFPDFYPSRPGFHQLEDVLTEDNVKNGFSSTTTPTGETFSMRNAIIPHMMAGCPEMLMALGQAIVEKRDELMPKFEERAFRIPVRVTYNDSKRLQFLTDLANPKVPLHRLMRNPVPHGFKGTELFESMFSPLTSSSSNAGHNRTPSASGKAAVDPIPLDRALWFIRVLGSNEISAHRSRAQPAAPVSAPSPAGATPSSTNTTSSTPALPLLSNDWYTQEFTNLFTAWLRIQLVQLSLPARGPLKASVPAKVGSGVLGDEKARARWSNKWDYSISLLRELHSRRLISCRIFTGWLADNLASANLSQLTFVALLSAQYIAALARHVSHGRLWIRAALERIKDIRSAIPASEALKRTESLLVTIITALFDAVPVVLLNPIAWRSNAELISEVILSSSSNEKTGARRAQQLADVRRRSEALVFRPVTTESTTSPRRQQMEEIHKLDSVCADTNMAELCKSFFDGSSSPSSPAVDVGRLEEKVFILMNWAMGLFQLGGHRPYASHTLIKLWLEQFDKHQSRSNNPQTMDFFPMLYKWLDTSAAGKKSENVLAVGITFGEFIRQGVFSYSRYLQTLIARGHTARSRHPKSPPSHHLALLRTMPIFVQAKDLLLQRRLALSGDDLEVRHRDEMDEAQALEAFKEEVREYVPEIFGWKRYGRSAALRDEVNHQMVTATTLTRYLFLQARFWIVPAVAEKLASGKGGMDASTFVRVMHVFRLCCGFSTIADLLIKALRTSDDEDILRVVIDAMQRDGDAWTAIDRWTQVTDALMYRHRLLAKNKKHLPAFSDLLLQLYKAGRLDEQSGIEIRKAVKRHTKSRGEVTNEPDKTQERVAKVVATIRSGDVAKAIALGKDMAAHNRSLDSWGLTWWRQVIEALCSDPTLPGTQQDILSAALGMIGTIDDACEANVASIVKKWLESLSLAEITDIFGQQNSMLPVMVLLYLVAQRRIPSLPVISNIVFPIWRAVSASILGNRSRLQGKQALAVESSVILAQQLLLDRPPHAIFPPTTLCEAHIVQTARTKILHADNVPELIRHLPFLVVFGSTPGVADRTRQEVSDLLQSLAMLPEFKTAAFRQLDLLKDAFLSSNWSKPGIEPTVEAGMVETLKMIMSDGSIGSSKPLPSISTALNATARFSAWRWTRVVLEMRVEFKRLAMRIDHGENATEARQTLNQLVHITLDRDISADDADLLCETFRGIEPIAAQEIFSVGLERLATLLGPIIEAEQQSHLEPLARSLDLMLRILSSGRDDKPVHVDQATFAARHRLIDLISIAMQAVERLVSADADLELPDGISPPQPGELLSVILKVLKFILGMPIMEQPGPAAPRPDFARLTASYFKVLTVLVGQANVAVPEWFTDMLTYVIDAVPPQARNSLHSALAAEASTSTAQVAFAKSTPLSNALPHWSPARRQTTLLGIRSSDEDSSDFALPLDDRSWELFEQMTPAPPALRHRDRFLASQPLKDTSSMPIALFKPRIIRDCLPQSANVSSEMDEGEIEVDEGYLGFASERNLGDGLAGEPLAVKQTMTQLYSASDDMEVEIEIDLTTTKSDIAESPANSISAVSAATATRPRRASTRLATGVRPNHGMGSNKDPITIGDDGDDDDDNDDESDLEAADEPLAKRARIGSKTTAATASRATTGGKAPSKKTTGGKAPAKRTTGGKSVRGHVGSKAPRGGGGRRRSGVD
Length1756
PositionKinase
OrganismNaematelia encephala
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Tremellomycetes> Tremellales> Naemateliaceae> Naematelia.
Aromaticity0.06
Grand average of hydropathy-0.228
Instability index49.88
Isoelectric point8.36
Molecular weight192989.99
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13815
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.80|      46|      68|    1605|    1651|       1
---------------------------------------------------------------------------
 1605- 1651 (69.75/48.47)	DDMEVEIEIDLTTTKSDIAESpANSISAVSAATATRPR...RASTRLATG
 1673- 1721 (70.06/43.23)	DDDDNDDESDLEAADEPLAKR.ARIGSKTTAATASRATtggKAPSKKTTG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.52|      58|      68|      68|     129|       2
---------------------------------------------------------------------------
   68-  105 (35.89/35.06)	..................................RTVLNQRADLgFPDFyPSRpGFHQLEDVLTEDNVKNGF
  106-  173 (88.20/65.89)	SSTTTPTGETFS.MRNAiIPHMMAGcpemlmalgQAIVEKRDEL.MPKF.EER.AFRIPVRVTYNDSKRLQF
  175-  198 (21.43/ 6.96)	TDLANPKVPLHRlMRNP.VPHGFKG...............................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.40|      76|     106|     820|     895|       3
---------------------------------------------------------------------------
  820-  885 (103.60/62.74)	..........................................AMQRDGDAWTAIDR.....WTQVTDALM.YRHRLLAKNKKHLPAFSDLLL..QLYKAGRLDEQSGIEIRKAVKR
  886-  986 (99.79/60.15)	HTKSRGEVTNepdktqervakvvatirsgdvakaialgkdmaAHNRSLDSW.GLTW.....WRQVIEALC.SDPTLPGTQQDILSA........ALGMIGTIDDACEANVASIVKK
  989- 1070 (52.01/27.58)	ESLSLAEITD...............ifgqqnsmlpvmvllylVAQRRIPSLPVISNivfpiWRAVSASILgNRSRL..QGKQALAVESSVILaqQLL....LD.............
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.34|      18|     107|     304|     321|       4
---------------------------------------------------------------------------
  304-  321 (32.63/20.33)	WLRIQL.....VQLSLPARGPLK
  407-  429 (24.70/13.36)	WIRAALerikdIRSAIPASEALK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.40|      22|     107|    1238|    1262|       5
---------------------------------------------------------------------------
 1238- 1260 (32.31/18.30)	ARQTLNQLVHITL...DRDISAdDAD
 1333- 1357 (30.09/11.69)	ARHRLIDLISIAMqavERLVSA.DAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.79|      41|     107|     563|     603|       6
---------------------------------------------------------------------------
  563-  603 (75.57/46.93)	MGLFQLGGHRPYASH..TLI..KLWLEQFD...KHQSRSNNPQT.....MDFF
  629-  670 (45.88/25.47)	FGEFIRQGVFSYSRYlqTLI..A......R...GHTARSRHPKSppshhLALL
  673-  712 (44.33/24.35)	MPIF......VQAKD..LLLqrRLALSGDDlevRHRDEMDEAQA.....LEAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.06|      24|     194|      10|      37|       7
---------------------------------------------------------------------------
   10-   37 (37.49/28.22)	SSQSFVGSATANLASGKGngtkSRHPLP
  211-  234 (43.57/23.34)	SSSSNAGHNRTPSASGKA....AVDPIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.43|      28|     194|    1284|    1311|       8
---------------------------------------------------------------------------
 1284- 1311 (48.45/25.16)	RLATLLGPIIEAEQQSHLE.PL.ARSLDLM
 1481- 1510 (41.98/20.89)	RQTTLLGIRSSDEDSSDFAlPLdDRSWELF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.22|      71|     398|    1118|    1193|      10
---------------------------------------------------------------------------
 1118- 1193 (107.21/77.94)	PGVADRTRQEVSDLLQSLAMLP..EFKTAAFRQLdLLKDAFLSSNWSKPGIEptVEAGMV.ETLKMIMSDGSIGssKPL
 1518- 1591 (114.01/67.09)	PALRHRDRFLASQPLKDTSSMPiaLFKPRIIRDC.LPQSANVSSEMDEGEIE..VDEGYLgFASERNLGDGLAG..EPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.33|      39|    1132|     259|     303|      11
---------------------------------------------------------------------------
  259-  303 (62.33/48.57)	PAAPvsAPSPAGATPSSTNTTS.....STPALPllsnDWYTQEFTNLFTA
 1394- 1437 (65.00/36.59)	PAAP..RPDFARLTASYFKVLTvlvgqANVAVP....EWFTDMLTYVIDA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13815 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDVLTEDNVKNGFSSTTTPTGETFSMRNAI
2) MPPTSRYPSSSQSFVGSATANLASGKGNGTKSRHPLPSRPGTNASTASDKGKAKEEVEIESFDPP
3) VKQTMTQLYSASDDMEVEIEIDLTTTKSDIAESPANSISAVSAATATRPRRASTRLATGVRPNHGMGSNKDPITIGDDGDDDDDNDDESDLEAADEPLAKRARIGSKTTAATASRATTGGKAPSKKTTGGKAPAKRTTGGKSVRGHVGSKAPRGGGGRRRSGVD
93
1
1593
122
65
1756










Molecular Recognition Features






MoRF SequenceStartStop




1) EAADEPLAKRARIGSKTTAATASRATTGGKAPSKKTTGGKAPAKRTTGGKSVRGHVGSKA
1684
1743