<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13807

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHNGAAGLTSPRDGQSRKRSHEGKLVNGNQKSPRPDGPVTAPTTITAASLPGLNGQSDQPTMNGAAPTVSAQMAHLPPELAHCSSEHYHPLSKLLARMSQECYNDLTETLTAMADIQPPQSNGLSNGLGAHLQDNSTSNRDKKLLILKFAHDQRAKFIKLLVLYDWAREYSEGVVKMVDVFQWCQRQLQEMDHVVWDMNNTKMSMATLRQQNPDIRTALEVLSTGKASWIPDLGFIPLDPMSSEKSRKLLRYMNTSLAIRLNVHENLPRHLRKWRVASGRATFTMPGEFELDTTAFSEDTSDQWHFIDIRLLFSPAPTVAADGRFYIFVKQQLDNILRQSGLSACFDFLHNFILTHKIAILRLQAYELLRADWAGALKVEPVHRSLVVSYWLDRPGRKSWVEINLASGKPKNGKVSWRGPGIASLGIRWFRQGVEVKHVDLKIDWNNLSMERILKRVIALHTSHFLQTARHQITSRLSERSWTKASLNLSESEPCDCSFELSLGSPENRIVASMDPVIGKFELRPCTPNAARAERAINQSKEPLASISAILPQLLSSSLLELVQQCTSRLGWRPAARYALKIDAVKQAVKLEVMQYALYTPRGWTTKGSGGNMITKWALAAIIDPSGESWWILELGTGGTTIDFAERITTESLSRQKLPVNLKTLASIDRIAAQLICFRITDRELSKRSIPCNLERQLALRPVNSHLVGSQDALHGWVLRLRAPDLLSSKPDEEQWLQPGLKVTCHGFRADLRNIWYIVSGFMIKTRDIDMRQLMAGSTQQDINFSENGSFSILLSTPFGQPMVDQATARLRDIDRLRSFAITLKKRKMVLKASSLEQVEFQYGKDCLATVNFAGDQGGIQVVFPPGNPHNGLATHLNNIINDKSPAPAALRQEDNSGLDRFCTTLMYTRPIIATLNELRDAQPGNVSNPRFHPRSVGTYRLEYTNPLCSFDIRIRPKQDAAFWHIEDNYRKNLDERSAAERFKERDRLDTLKAALAVLFRSQGEGWVGIRSGVVAELDGIPNALKKLNETVLSCEVAGGLGYQLSRTPSSGVPPNVRPNPQGGGAPGGTANMRRPQDNVNNNAHPLNLPNGRQVPLGRGAGPVTMGTSSEPINLD
Length1117
PositionTail
OrganismClohesyomyces aquaticus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces.
Aromaticity0.07
Grand average of hydropathy-0.372
Instability index44.16
Isoelectric point9.34
Molecular weight124460.69
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.79|      19|      91|     472|     490|       1
---------------------------------------------------------------------------
  472-  490 (33.16/20.47)	HQITSRLSERSWTKASLNL
  565-  583 (35.63/22.59)	QQCTSRLGWRPAARYALKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     402.47|     111|     401|     226|     352|       2
---------------------------------------------------------------------------
  230-  349 (176.50/123.94)	WIPDLGF..IPLDPMSSEKSRKLLRYMNTSLAIRLNVHENLPR...HLRKWRVASGR.ATFTMPGEFELD.....TTAFSEDTSDQ..WHFIDIRLLFSPAPTVAADgrfyifvKQQLDNILrQSGL.sACFDF
  632-  749 (143.68/77.65)	WILELGTggTTIDFAERITTESLSR...QKLPVNLKTLASIDRiaaQLICFRITDRElSKRSIPCNLERQlalrpVNSHLVGSQDA..LHGWVLRL...RAPDLLSS.......KPDEEQWL.QPGLkvTCHGF
  756-  824 (82.29/48.48)	....IWY..IVSGFMIKTRDIDMRQLMAGSTQQDINFSEN..................GSFSI.....LL.....STPFGQPMVDQatARLRDIDRLRSFAIT...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.96|      38|    1062|       5|      44|       3
---------------------------------------------------------------------------
    5-   44 (62.33/55.12)	GAAGLTSPRDGQSrKRSHEGKLVNGNQkSP..RPDGPVTAPT
 1070- 1109 (68.63/49.94)	GTANMRRPQDNVN.NNAHPLNLPNGRQ.VPlgRGAGPVTMGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.57|      39|     205|     388|     430|       4
---------------------------------------------------------------------------
  388-  430 (63.05/51.32)	VVSYWLDRPgrKSWVeiNLASGKPKNGKVSWR.GPGIASLGIRW
  501-  525 (26.34/10.31)	.................ELSLGSPENRIVASM.DPVIGKFELR.
  594-  631 (63.19/38.84)	VMQYALYTP..RGWT....TKGSGGNMITKWAlAAIIDPSGESW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.98|      20|     744|     119|     143|       5
---------------------------------------------------------------------------
  119-  143 (21.62/27.96)	PPqSNGlSNGLGAHLqdNSTSNrDK
  866-  885 (41.36/22.70)	PP.GNP.HNGLATHL..NNIIN.DK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13807 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNHNGAAGLTSPRDGQSRKRSHEGKLVNGNQKSPRPDGPVTAPTTITAASLPGLNGQSDQPTMNGAAPTVSAQMAHLPPELAHC
2) QLSRTPSSGVPPNVRPNPQGGGAPGGTANMRRPQDNVNNNAHPLNLPNGRQVPLGRGAGPVTMGTSSEPINLD
1
1045
84
1117










Molecular Recognition Features






MoRF SequenceStartStop




NANANA