<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13804

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSSHPPKRQRLNGSFSPASPPYHQAVKPNDHHTKPIVHPNTPTSPPYMSTNPQPNGGFPATATAPSTEMTPPSSVSMSQQVSQLGASASNPLPFPTPSSTTGVAFANIDSDGDVAMAEDGNDDTAQSAKNRRSNHNRQRKGKGAVLFGERGPIDGLLFKLHENEHPNSRPHGSQNLFDLYGLNNVAATVARTDPVTGEKINKLRKSYEGHIKQLHISGRPKANKIEGALTDPLRMPDEEWQSQKITGKDMKNAFNDSGSALSKNFDSLLSGALTGTAPGALPNPETQRYRTYIGTDEVKPKPGGTEGMSAGRVLQPNPGTPFSSAPSPAPRSMRPERSGAKRSYQDTSFVGYSEGFADDADSTAGEEAGPKKKQKFGFGAAHPMGMVGGVRR
Length392
PositionHead
OrganismClohesyomyces aquaticus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces.
Aromaticity0.06
Grand average of hydropathy-0.857
Instability index54.78
Isoelectric point9.44
Molecular weight41786.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13804
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.05|      25|      27|      45|      71|       2
---------------------------------------------------------------------------
   45-   69 (47.23/18.63)	PPYMSTNPQPNGGFPATATAPSTEM
   71-   95 (43.82/22.07)	PPSSVSMSQQVSQLGASASNPLPFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.46|      27|      27|     323|     349|       3
---------------------------------------------------------------------------
  300-  319 (26.78/ 9.85)	.......PKPGGTEGMSAGRVLQPNPG
  323-  349 (46.44/22.61)	SSAPSPAPRSMRPERSGAKRSYQDTSF
  353-  378 (41.24/19.24)	SEGFADDADSTAGEEAGPKKK.QKFGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.07|      26|      27|     197|     223|       4
---------------------------------------------------------------------------
  197-  223 (40.86/34.09)	GEKINKLRKSYEGHIKQlHISGRPKAN
  227-  252 (47.21/34.47)	GALTDPLRMPDEEWQSQ.KITGKDMKN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13804 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GALTGTAPGALPNPETQRYRTYIGTDEVKPKPGGTEGMSAGRVLQPNPGTPFSSAPSPAPRSMRPERSGAKRSYQDTSFVGYSEGFADDADSTAGEEAGPKKKQKFGFGAAHPMGMVGGVRR
2) MSSHPPKRQRLNGSFSPASPPYHQAVKPNDHHTKPIVHPNTPTSPPYMSTNPQPNGGFPATATAPSTEMTPPSSVSMSQQVSQLGASASNPLPFPTPSSTTGVAFANIDSDGDVAMAEDGNDDTAQSAKNRRSNHNRQRKGKGAVLF
3) SYEGHIKQLHISGRPKANKIEGALTDPLRMPDEEWQSQKITGKDMKNAFNDSGSAL
271
1
206
392
147
261










Molecular Recognition Features






MoRF SequenceStartStop




1) HPPKRQRLNGSF
2) LLFKLH
3) PKKKQKFGF
4) QRYRTYIG
5) YHQAVKPNDHHTKPIVH
4
156
370
287
22
15
161
378
294
38