Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDAILHSQFQRVEAALSTLVDSIASYNPNPQAAVDLVAADEELSKGLELLAQHQANHARILSLRHEVDSLAAQLKTSVSTLADLRHEIFDTPATTESESSRSVPINELLQYAKNISRYTVPPTYREPIPKGDSDTEKVREKDDASGGLPSNGLGTPVGPPGSMVIADPPASKDAAPEEEEKQVTAEQAEWLTKLHEAGVQWVPWPSHDKIRKGGLMVIQDMVDRGLDPHTRLLPAEQELLDRQRREAADLMKQQKEEKQREYEMRIENAKKAKAAQQAQGPETQQKEKAQEKPATFTAFDMYDEDEDMEQ |
Length | 310 |
Position | Middle |
Organism | Clohesyomyces aquaticus |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.788 |
Instability index | 48.51 |
Isoelectric point | 4.85 |
Molecular weight | 34521.05 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP13802 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.66| 17| 19| 51| 68| 1 --------------------------------------------------------------------------- 51- 67 (29.39/23.19) AQHQANHARILSLRHEV 72- 88 (27.27/15.18) AQLKTSVSTLADLRHEI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ETQQKEKAQEKPATFTAFDMYDEDEDMEQ 2) EYEMRIENAKKAKAAQQAQG | 282 261 | 310 280 |
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