<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13801

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGDDKLINDLSINSIQNDFDLLPKNEENLIPLKDIYEGVIHRYYSELLNLSETLTNKVNREKKVEIFKLIQDFIQNATKLLVLLRWAKQSKDVLKYKNIYDFLELQNSYFRGAADALHMVHQEMNLARIPNFDISTAVDVLTTGTYSRLPSIIKEPISLPPLKNEEIKDAIEKLEDVTRMRLLCDEIVPKPMKKNYVIENGAVRFTVENEFEVTLRLEGKQQDNWRLLDLKIFVKPDEDLNHDLIIPLQEYQINFLKNNAQVIISKDATNVDLNQNPNINLITNPPNAATSTNNTNSNEEEKSTTPKKIWPLIELYRYLHSFCLSMQLEIFRLQIEYLIKTRWANRLRFNMSADQKTLQLFYWNEKEKNRNMEINKNKDLKNKEGKKSNIVELSITTAEDKVVFYTNKENKEDNSNSLLIAKSQTYEYEQYIQSNLTIHCYQLLEDGTKKELIDPTTSSKVKFNINSQKLNIEKILDRVTEVHAFSILFELKNILIGKSNSNITIHKCNSNDVIEKNFYNSKTTDEEMEKQQPELIICYRINHYVKITVDGRTGRIVITEYNEQGTDNINSFIQEKIKNVEEKINKDMTKAVDYLIELRNLTIINEIELLSIYLGLEPSKKLLITQEEIKSSSRNKHDSSYFKVWLVSTKKKNSSGFLEFSLIMNLDISQLLENDNIKDDSDNEQDNFHHLRKRRCIEEQSIWDKTKYKIAYCLLTTQLKNLHIPYYFISLKSKNHVIDYDSPLSIFDLIIKIRVKDIIPDVIRKCVLGDYVLKLNNDLYITATGNTLNNENNAGPFEKFSIKNHVKGIARGIKVVAKLQIKPGELPINEDFSIGKNLLRDINFSVKTKVLTFTYSKINDCIYRILNIWKGLVMLRIIASQAYTNRDILESHEMTIDKINLLKTKILFYEKNYVEFALNSNLDNPNSNGINIIFGIKGDNKSTVFYKEKEFLIEDFLMDYNVINFLLKSREMINTYSTLKVEKESLEKIKLIYNQYTIEIGQCTENLVGILCSDSSYGIQSKVNMIPQFQSFIDKVVQLHATNTPPKKSDLDEKATKEDKEKENKNGNEQTKGEEQEDCICMKIPNGIIFEIRYIDQVMNSLNKLMNGISYMDWLYNTINQIEANKQNKGKINYSKKAKGPLLLSYEGESLEFTLSFDFDKKQNDEKKDEEKNNEKNKEKEWSMKLKSNGESLKGDILIEKILNLKNPIVGFKSLTQLMILPPEIAKEILKIICLEKKENQHKVISEICLAVPEGLPGYLPNAGESAIYTDFQNKRIGLICQIYYNDVSANGQTNETSQSKHSIIIPFFYNWRSKFFCEWNGDPEFSKLEDTNKCISWLRDERHGELSRLNLFFIQISKAFEQNKEKGEKEAIQFAFNTLSSMKPEQYKAIEIKN
Length1396
PositionTail
OrganismNeocallimastix californiae
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Chytridiomycota> Chytridiomycota incertae sedis> Neocallimastigomycetes> Neocallimastigales> Neocallimastigaceae> Neocallimastix.
Aromaticity0.09
Grand average of hydropathy-0.519
Instability index36.06
Isoelectric point6.47
Molecular weight162406.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13801
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     312.90|      94|     112|     322|     433|       1
---------------------------------------------------------------------------
  322-  421 (141.96/72.36)	SfclSMQLEIFRL....QIEYLIKTRWANRLRFNMSAdQKTLQLFYwnEKEKNRNMEINKNK...DLKNKE.GKKSNIVEL..SITTAEDKV..VFY...TNKENKEDNSNSLLI
  435-  538 (123.03/61.57)	S...NLTIHCYQLledgTKKELIDPTTSSKVKFNINS.QK.LNI....EKILDRVTEVHAFSilfELKNILiGKSNSNITI..HKCNSNDVIekNFYnskTTDEEMEKQQPELII
  904-  951 (47.91/13.64)	.......................................KTKILFY....EKN.YVEFALNS...NLDN....PNSNGINIifGIKGDNKST..VFY...KEKE...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.30|      35|     121|     563|     604|       2
---------------------------------------------------------------------------
  563-  604 (46.43/52.81)	NEQgtDNINSFiqEKIKNVEEKINKDMTKavdYLI.......ELRNLTI
  684-  725 (59.87/41.29)	NEQ..DNFHHL..RKRRCIEEQSIWDKTK...YKIaycllttQLKNLHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.74|      27|     121|     831|     857|       3
---------------------------------------------------------------------------
  126-  148 (23.58/11.79)	.......NLARIPNFDISTAVdvlTTGTYS
  831-  857 (48.36/32.48)	EDFSIGKNLLRDINFSVKTKV...LTFTYS
  955-  978 (42.80/27.84)	EDFLMDYNV...INFLLKSRE...MINTYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.01|      45|     121|    1053|    1100|       4
---------------------------------------------------------------------------
 1053- 1100 (74.78/45.94)	DEKATKEDKEKE....NKNGNEQTKGE.EQEDCICMKIPngiIFEIRYIDQVM
 1171- 1220 (64.23/32.57)	EEKNNEKNKEKEwsmkLKSNGESLKGDiLIEKILNLKNP...IVGFKSLTQLM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13801 with Med14 domain of Kingdom Fungi
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