<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP13797

Description Uncharacterized protein
SequenceMTSRPGPGIPEALQYRGSGGPARAQVRRRPSKPSLNPHNVPHQDCIDPTLEDQRRSAEETLTRSRGLALAKGKQAALEGIQTAPGDQIRPPPRGKPQLFFSNITTNGPDQLLQSPHGQPATVGTNWPVPPRPGASMPGHGSQLRRIMPGGTGVKGEPAVKFPSPDAPAAAILFPGGKTADLFPWTGNNPEDTLSETLVKGGISNKPQIMNETNTARPSLWSNLKNKSGLGTLSTLFVAVLEKRQSSGRLATANTFKPPPRLTLRDSTREAWLHDLANPTVSLRRLSRTIPHGITGKVLLEQCLNKNIPRDRAMWLAKCVGINEMRSHKRKGQAGTITWVRGWTSAVEQFLDSIVATIGQPEWKPRITYALQFATELYQQHLLEVDHFLDWLLKNLEACPTERLFLWLLLISVYWSGLTCCRRRGKRLGETLLAHAERLYQIDQDPVSPVVELLENIIIKLISNCPACFLLPKSWDRHVLVLRRLAEKRHHPQIIHAIETLDRRNKRLLRSSGSVPTGAHDSARHVVCLLDSVDYVAGVNIETLALQCMEHIPEPRHLISLALKWASSLHREGSHRIYLVTRLIRKWNQIGTDVDEAILVHLQSVASTGQTDPRYLFRIIAELVRSKTFSVGRYLQWLIATGAINKSRELSTAEAWPLRLITEIPLTGLSEQIQNLRATLLHGTAYSTELEDQQIDDAQSFIQRRIPDLFDESEYVDLSVEVNFASISSTVRLELGIWIRLLVQANVQLVDRVPTKDSSIEEPGQVCTISPQSFHAVRSYLEDFDDLSILADVLGLATFSLDPNVLTAVADTLHYHHKAFAAIGAFKPLFQRLAMRYAAVRTVRFPERELLVALTDVARTARADEQLMLMLAYDLNRCEQKNSLAACSPASDNMDTTMDTDDEIERILSSGTSMDQQVMMRVFTKVVMRLEEQLGSGSIQSDSLGSWFYRLRSFDEKAFEKLLFEWLSSLLNAHRGKLMLAALPPLVVSGCLTLHQFLEVSRRCISERRASNEDGLLRMSAEVLNALLPSEQLGRFCQPQDAYRFRLEQQRLCQDPEGRILLVIHDTFEASARQLPPALATQVNNLLSSNRLRSVVRHLAVSNTQLVSKALDIGAHPTSEIMNARIKSLLDGLLDPTDQLGLARKTLEQQVDLVVNTANDLGLPFCQLEIRQIFAMSEGSAETISAAFLEAIKAAVEKNVSPWSDLVAGLDADLTSKIREHAEREILKASAFLSSPSTLELENLNGANESLLEKFLTVMDLTASGTPGDGQYPFFAAVAERLKGLAEILGRPSDFTNALAGKSLPAIAQLSPWLHALLRLVAVQDSTAANKANSQHQAALLLSLRSLFSHPAFRSYPAMAEYIFDIAVVLSDAASDEVRAHLYRLETMKPSEDSRCAYIFGTAPPLDGWLALSKPVAPALNQQPTSSQPVQSQQQGLAQSSHYQNQQNQPPNPTPMQRSLSQHHQQQQMQAQAQAQARMYPQYPQHPQQPPNKLPPQFQRMASNPGQSPQQSQLQQMQQMQQMQGLAQQRASQPSPVQMQRQASMSSASGSQNSNSTPGSQGRPGAPPARQEKPEMRTLPFALRRWEILPESGGMASANETAISLTLFGARKV
Length1612
PositionKinase
OrganismClohesyomyces aquaticus
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Lindgomycetaceae> Clohesyomyces.
Aromaticity0.06
Grand average of hydropathy-0.299
Instability index53.61
Isoelectric point8.58
Molecular weight178778.02
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP13797
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.94|      14|      16|     287|     302|       1
---------------------------------------------------------------------------
  287-  302 (20.88/19.30)	RTIPHGitGKVLLEQC
  305-  318 (27.06/17.48)	KNIPRD..RAMWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.61|       9|      16|    1030|    1039|       2
---------------------------------------------------------------------------
 1030- 1039 (15.84/12.57)	EQlGRFCQ.PQ
 1047- 1056 (14.78/ 6.02)	EQ.QRLCQdPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      95.67|      20|      20|    1427|    1446|       3
---------------------------------------------------------------------------
 1427- 1443 (27.98/14.01)	...........QPVQSQ..QQ.GLAQSSHYQ
 1444- 1464 (24.56/11.18)	NQQ.......nQPPNPTpmQR.SLSQ..HHQ
 1482- 1507 (24.15/10.84)	YPQhpqqppnkLPPQFQ..R...MASNPGQS
 1528- 1551 (18.98/ 6.56)	.QR....asqpSPVQMQ..RQaSMSSASGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.21|      16|      16|     840|     855|       4
---------------------------------------------------------------------------
  840-  855 (26.68/17.56)	RTVRFPERELLVALTD
  858-  873 (27.52/18.37)	RTARADEQLMLMLAYD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.66|      31|      79|     422|     456|       5
---------------------------------------------------------------------------
  422-  456 (47.25/38.13)	RRGKRlgetLLAHAERLYQIDQDPVSPVVELLENI
  502-  532 (53.41/33.15)	RRNKR....LLRSSGSVPTGAHDSARHVVCLLDSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.69|      20|      20|      77|      96|       6
---------------------------------------------------------------------------
   77-   96 (38.48/19.20)	LEGIQTAPGDQIRPPPRGKP
  100-  119 (38.21/19.01)	FSNITTNGPDQLLQSPHGQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.39|      17|      19|    1134|    1150|       7
---------------------------------------------------------------------------
 1134- 1150 (28.91/17.08)	DPTDQLGLARKTLE.QQV
 1155- 1172 (26.48/14.98)	NTANDLGLPFCQLEiRQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.03|      17|      18|     604|     620|      10
---------------------------------------------------------------------------
  604-  620 (30.26/16.37)	VASTGQTDPRYLFRIIA
  623-  639 (30.77/16.75)	VRSKTFSVGRYLQWLIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.08|      16|      16|     946|     961|      11
---------------------------------------------------------------------------
  946-  961 (29.19/18.25)	WFYRLRSFDEKAFEKL
  962-  977 (27.89/17.10)	LFEWLSSLLNAHRGKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.61|      12|      16|     223|     234|      12
---------------------------------------------------------------------------
  223-  234 (19.30/14.77)	LKNKSGLGTLST
  240-  251 (19.31/14.78)	LEKRQSSGRLAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      16|      20|    1272|    1287|      13
---------------------------------------------------------------------------
 1272- 1287 (27.02/16.53)	P..FFAAVAER.LKGLAEI
 1291- 1309 (18.47/ 8.83)	PsdFTNALAGKsLPAIAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.23|      12|      16|     782|     793|      15
---------------------------------------------------------------------------
  782-  793 (20.02/13.59)	DFDDLSILADVL
  801-  812 (20.21/13.79)	DPNVLTAVADTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.50|      15|      22|     334|     349|      21
---------------------------------------------------------------------------
  334-  349 (25.31/21.10)	GTITWVRGWTSAVeQF
  358-  372 (30.18/20.02)	GQPEWKPRITYAL.QF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP13797 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADLFPWTGNNPEDTLSETLVKGGISNKPQIMNETNTARPSLWSNL
2) ALSKPVAPALNQQPTSSQPVQSQQQGLAQSSHYQNQQNQPPNPTPMQRSLSQHHQQQQMQAQAQAQARMYPQYPQHPQQPPNKLPPQFQRMASNPGQSPQQSQLQQMQQMQQMQGLAQQRASQPSPVQMQRQASMSSASGSQNSNSTPGSQGRPGAPPARQEKPEMRTLPFALRRWEILPESGGMASANETAISLTL
3) MTSRPGPGIPEALQYRGSGGPARAQVRRRPSKPSLNPHNVPHQDCIDPTLEDQRRSAEETLTRSRGLALAKGKQAALEGIQTAPGDQIRPPPRGKPQLFFSNITTNGPDQLLQSPHGQPATVGTNWPVPPRPGASMPGHGSQLRRIMPGGTGVKGEPAVKFPSPDAPAAA
179
1410
1
223
1606
170










Molecular Recognition Features






MoRF SequenceStartStop




1) EMRTLPFALRRWEIL
2) PGIPEALQYRGSGGPARAQVRRRP
1574
7
1588
30